Institut für Medizinische Statistik - UMG

PD Dr. Antonia Zapf

Wissenschaftliche Mitarbeiterin - AG Klinische Studien
Humboldtallee 32, EG 154


Methodische Forschung Praktische Anwendung Lehre zu den Themen
Weitere wissenschaftliche Tätigkeiten (Auswahl)

01/2017 Habilitationspreis der Universitätsmedizin Göttingen
05/2016 Abschluss der Habilitation an der Universitätsmedizin Göttingen
Venia legendi im Fach Medizinische Biometrie, Thema der Habilitation: Methoden zur Evaluierung und Selektion diagnostischer Tests
04/2014 - 11/2015 Gefördert durch das Heidenreich von Siebold-Programm
der Universitätsmedizin Göttingen
12/2012 Zertifikat "Biometrie in der Medizin"
der Deutschen Gesellschaft für Medizinische Informatik, Biometrie und Epidemiologie (GMDS) und der Deutschen Region der Internationalen Biometrischen Gesellschaft (IBS-DR)
Seit 08/2012 Wissenschaftliche Mitarbieterin, Institut für Medizinische Statistik,
Universitätsmedizin Göttingen
03/2009 - 07/2012 Wissenschaftliche Mitarbeiterin, Institut für Biometrie,
Medizinische Hochschule Hannover
10/2009 Promotion zum Dr. rer. nat.
im Rahmen des Promotionsstudiengangs „Applied Statistics & Empirical Methods“ am Zentrum für Statistik (ZfS), Georg-August-Universität Göttingen
10/2006 - 02/2009 Wissenschaftliche Mitarbeiterin, Abteilung Medizinische Statistik,
Universitätsmedizin Göttingen
10/2001 - 10/2006 Studium der Statistik (Diplom), mit Nebenfach Medizinische Biometrie,
Ludwig-Maximilians-Universität (LMU), München

Psychogios MN, Behme D, Schregel K, Tsogkas I, Maier IL, Leyhe JR, Zapf A, Tran J, Bähr M, Liman J, Knauth M (2017). One-Stop Management of Acute Stroke Patients: Minimizing Door-to-Reperfusion Times. Stroke, Epub ahead of print.
Fasshauer M, Krüwel T, Zapf A, Stahnke VC, Rave-Fränk M, Staab W, Sohns JM, Steinmetz M, Unterberg-Buchwald C, Schuster A, Ritter C, Lotz J (2017). Absence of DNA double-strand breaks in human peripheral blood mononuclear cells after 3 Tesla magnetic resonance imaging assessed by ?H2AX flow cytometry. Eur Radiol, Epub ahead of print.
Pickenbrock H, Ludwig VU, Zapf A (2017). Support pressure distribution for positioning in neutral versus conventional positioning in the prevention of decubitus ulcers: a pilot study in healthy participants. BMC Nursing, Epub ahead of print.
Hesse AC, Behme D, Kemmling A, Zapf A, Hokamp NG, Frischmuth I, Maier I, Liman J, Tsogkas I, Buhk JH, Tran J, Fiehler J, Mpotsaris A, Schramm P, Berlis A, Knauth M, Psychogios MN (2017). Comparing different thrombectomy techniques in five large-volume centers: a 'real world' observational study. J Neurointerv Surg, Epub ahead of print.
Wienbeck S, Uhlig J, Luftner-Nagel S, Zapf A, Surov A, von Fintel E, Stahnke V, Lotz J, Fischer U (2017). The role of cone-beam breast-CT for breast cancer detection relative to breast density. Eur Radiol, Epub ahead of print.
Weber-Krüger M, Lutz C, Zapf A, Stahrenberg R, Seegers J, Witzenhausen J, Wasser K, Hasenfuß G, Gröschel K, Wachter R (2017). Relevance of supraventricular runs detected after cerebral ischemia. Neurology, 89(15):1545-1552.
Czerner CP, Winther HB, Zapf A, Wacker F, Vogel-Claussen J (2017). Breath-hold and free-breathing 2D phase-contrast MRI for quantification of oxygen-induced changes of pulmonary circulation dynamics in healthy volunteers. J Magn Reson Imaging, Epub ahead of print.
Bültmann E, Mußgnug HJ, Zapf A, Hartmann H, Nägele T, Lanfermann H (2017). Changes in brain microstructure during infancy and childhood using clinical feasible ADC-maps. Childs Nerv Syst, 33(5):735-745.
Wienbeck S, Nowak C, Zapf A, Stamm G, Unterberg-Buchwald C, Lotz J, Fischer U (2017). Artifacts caused by breast tissue Markers in a dedicated cone-beam breast CT in comparison to full-field digital mammography. Acad Radiol, 24(7):908-915.
Körner S, Böselt S, Wichmann K, Thau-Habermann N, Zapf A, Knippenberg S, Dengler R, Petri S (2016). The Axon Guidance Protein Semaphorin 3A Is Increased in the Motor Cortex of Patients With Amyotrophic Lateral Sclerosis. J Neuropathol Exp Neurol [Epub ahead of print].
Zapf A, Castell S, Morawietz L, Karch A (2016). Measuring inter-rater reliability for nominal data - which coefficients and confidence intervals are appropriate? BMC Medical Research Methodology, 16:93.
Karch A, Koch A, Zapf A, Karch A (2016). Partial verification bias and incorporation bias affected accuracy estimates of diagnostic studies for biomarkers that were part of an existing composite gold standard. J Clin Epidemiol, 78:73-82.
Förster J, Ahlenstiel-Grunow T, Zapf A, Mynarek M, Pape L (2016). Pubertal development in pediatric kidney transplant patients receiving mammalian target of Rapamycin inhibitors or conventional immunosuppression. Transplantation, 100(11):2461-2470.
Pickenbrock H, Diel A, Zapf A (2016). A comparison between the Static Balance Test and the Berg Balance Scale: Validity, reliability, and comparative resource use. Clinical rehabilitation, 30(3):288-293.
Zapf A, Hoyer A, Kramer K, Kuss O (2015). Nonparametric meta-analysis for diagnostic accuracy studies. Statistics in Medicine, 34(29):3831-3841.
Pickenbrock HM, Zapf A (equally contributed), Dressler D (2015). Effects of therapeutic positioning on vital parameters in patients with central neurological disorders: a randomised controlled trial. J Clin Nurs, 24(23-24):3681-3690.
Brunkhorst LC, Fichtner A, Höcker B, Burmeister G, Ahlenstiel-Grunow T, Krupka K, Bald M, Zapf A, Tönshoff B, Pape L (2015). Efficacy and Safety of an Everolimus- vs. a Mycophenolate Mofetil-Based Regimen in Pediatric Renal Transplant Recipients. PLoS One, 10(9):e0135439.
Zapf A, Gwinner W (equally contributed), Karch A, Metzger J, Haller H, Koch A (2015). Non-invasive diagnosis of acute rejection in renal transplant patients using mass spectrometry of urine samples - a multicentre phase 3 diagnostic accuracy study. BMC Nephrol, 16:153.
Kretschmer L, Bertsch HP, Zapf A, Mitteldorf C, Satzger I, Thoms KM, Völker B, Schön MP, Gutzmer R, Starz H (2015). Nodal Basin Recurrence After Sentinel Lymph Node Biopsy for Melanoma: A Retrospective Multicenter Study in 2653 Patients. Medicine (Baltimore), 94(36):e1433.
Zapf A, Brunner E, Konietschke F (2015). A Wild Bootstrap approach for the selection of biomarkers in early diagnostic trials. BMC Medical Research Methodology, 15(1):43.
Körner S, Kollewe K, Abdulla S, Zapf A, Dengler R, Petri S (2015). Interaction of physical function, quality of life and depression in Amyotrophic lateral sclerosis: characterization of a large patient cohort. BMC Neurol, 15:84.
Sohns J, Schulte C, Zapf A, Unterberg-Buchwald C, Staab W, Kowallick J, Lauerer P, Nguyen T, Fasshauer M, Paul T, Lotz J, Steinmetz M (2015). Right atrial volume is increased in corrected Tetralogy of Fallot and correlates with the incidence of supraventricular arrhythmia - a CMR study. Pediatric Cardiology, 36(6):1239-47.
Pickenbrock H, Ludwig VU, Zapf A, Dressler D (2015). Conventional versus neutral positioning in central neurological disease: a multicenter randomized controlled trial. Dtsch Arztebl Int, 112(3):35-42.
Schröder M, Stüber V, Walendzik E, O`Loughlin PF, Zapf A, Krettek C, Gaulke R (2015). Establishing an optimal trajectory for calcaneotibial K-wire fixation in emergent treatment of unstable ankle fractures. Technol Health Care, 23(2):215-21.
Satzger I, Meier A, Zapf A, Niebuhr M, Kapp A, Gutzmer R (2014). Is there a therapeutic benefit of complete lymph node dissection in melanoma patients with low tumor burden in the sentinel node? Melanoma Res. 24(5):454-61.
Kottas M, Kuss O, Zapf A (2014). A modified Wald interval for the area under the ROC curve (AUC) in diagnostic case-control studies. BMC Medical Research Methodology, 14:26.
Brunner E, Zapf A (2014). Nonparametric ROC analysis for diagnostic trials. Statistics in Clinical Trials - Planning, Analysis, and Inferential Methods, Vol. 2 (Editor N. Balakrishnan), 471-483. John Wiley & Sons, Newark, NJ.
Neufeld J, Roy M, Zapf A, Sinke C, Emrich HM, Prox-Vagedes V, Dillo W, Zedler M (2013). Is synesthesia more common in patients with Asperger syndrome? Front Hum Neurosci, 7:847.
Moll MA, Seuthe M, von See C, Zapf A, Hornecker E, Mausberg RF, Ziebolz D (2013). Comparison of clinical and dental panoramic findings: a practice-based crossover study. BMC Oral Health, 13(1):48.
Körner S, Hendricks M, Kollewe K, Zapf A, Dengler R, Silani V, Petri S (2013). Weight loss, dysphagia and supplement intake in patients with amyotrophic lateral sclerosis (ALS). BMC Neurol, 13:84.
Wenzel D, Zapf A (2013). Difference of two dependent sensitivities and specificities: comparison of various approaches. Biom. J., 55(5):705-718.
Andruszkow H, Scharff B, Zapf A, Klein M, Lerchler P, Hildebrand F, Frink M (2013). Influence of comorbidities and delay in surgical treatment on mortality following femoral neck fracture. Z Orthop Unfall, 151(4):338-342.
Goldschmidt I, Streckenbach C, Dingemann C, Pfister ED, di Nanni A, Zapf A, Baumann U (2013). Application and limitations of transient liver elastography in children. J Pediatr Gastroenterol Nutr, 57(1):109-113.
Pape L, Ahlenstiel T, Werner CD, Zapf A (2013). Development and validation of a new statistical model for prognosis of long-term graft function after pediatric kidney transplantation. Pediatr Nephrol, 28(3):499-505.
Körner S, Siniawski M, Kollewe K, Rath KJ, Krampfl K, Zapf A, Dengler R, Petri S (2013). Speech therapy and communication device: Impact on quality of life and mood in patients with amyotrophic lateral sclerosis. Amyotroph Lateral Scler,14(1):20-5.
Hueper K, Zapf A, Skrok J, Pinheiro A, Goldstein TA, Zheng J, Zimmermann SL, Kamel IR, Abraham R, Wacker F, Bluemke DA, Abraham T, Vogel-Claussen J (2012). In hypertrophic cardiomyopathy reduction of relative resting myocardial blood flow is related to late enhancement, T2-signal and LV wall thickness. PLoS One, 7(7):e41974.
Steiert A, Reimers K, Burke W, Zapf A, Vogt P (2012). Covalent vectored binding of functional proteins by bifunctional crosslinking at silicone interfaces. J Biomed Mater Res Part A, J Biomed Mater Res A, 100(5):1248-55.
Fricke-Zech S, Gruber RM, Dullin C, Zapf A, Kramer FJ, Kubein-Meesenburg D, Hahn W (2012). Measurement oft he midpalatal suture width. Angle Orthod, 82(1): 145-50.
Rana M, Zapf A, Kühle M, Gellricht NC, Eckardt AM (2012). Clinical evaluation of an autofluorescence diagnostic device of oral cancer detection: a prospective randomized diagnostic study. Eur J Cancer Prev, 21(5):460-6.
Drebenstedt S, Zapf A, Rödig T, Mausberg R, Ziebolz D (2011). Efficacy of two different CHX-containing desensitizers: A controlled double-blind study (2011). Oper Dent, 37(2):161-71.
Rödig T, Hirschleb M, Zapf A, Hülsmann M (2011). Comparison of ultrasonic irrigation and RinsEndo for the removal of calcium hydroxide and Ledermix paste from root canals. Int Endod J, 44(12): 1155-61.
Jäger MD, Kaaden S, Emmanouilidis N, Lück R, Beckmann JH, Güner Z, Kespohl H, Glockzin K, Aselmann H, Kaudel CP, Schwarz A, Zapf A, Klempnauer J, Scheumann GF (2011). Effect of incomplete parathyoidectomy preserving entire parathyroid glands on renal graft function. Arch Surg, 146(6):704-10.
Körner S, Kollewe K, Fahlbusch M, Zapf A, Dengler R, Krampfl K, Petri S (2011). Onset and spreading patterns of upper and lower motor neuron symptoms in amyotrophic lateral sclerosis. Muscle Nerve, 43(5): 636-42.
Ziebolz D, Stühmer C, Hornecker E, Zapf A, Mausberg RF, Chenot JF (2011). Oral health in adult patients with congenital coagulation disorders – a case control study. Haemophilia, 17(3): 527-31.
Heuser M, Zapf A (equally contributed), Morgan M, Krauter J, Ganser A (2011). Myeloid growth factors in acute myeloid leukemia: systematic review of randomized controlled trials. Ann Hematol, 90(3): 273-81.
Lüers C, Schmidt A, Wachter R, Fritzsche F, Sutcliffe A, Kleta S, Zapf A, Hagenah G, Binder L, Maisch B, Pieske B (2010). Serial NT-proBNP measurements for risk stratifycation of patients with decompensated heart failure. Herz, 35(7): 488-95.
Derichs N, Sanz J, Von Kanel T, Stolpe C, Zapf A, Tümmler B, Gallati S, Ballmann M (2010). Intestinal current measurement for diagnostic classification of patients with questionable cystic fibrosis: validation and reference data. Thorax, 65(7): 594-9.
Rödig T, Vogel S, Zapf A, Hülsmann M (2010). Efficacy of different irrigants in the removal of calcium hydroxide from root canals. Int Endod J, 43(6): 519-27.
Hahn W, Zapf A, Dathe H, Fialka-Fricke J, Fricke-Zech S, Gruber R, Kubein-Meesenburg D, Sadat-Khonsari R (2010). Torquing an upper central incisor with aligners – acting forces and biomechanical principles. Eur J Orthod, 32(6): 607-13.
Koziolek M, Hennig U, Zapf A, Bramlage C, Grupp C, Armstrong V, Strutz F, Müller G (2010). Retrospective analysis of long-term lipid apharesis at a single center. Ther Apher Dial, 14(2): 143-52.
Bramlage C, Armstrong V, Zapf A, Pramlage P, Müller G, Koziolek M (2010). Low-density lipoprotein apheresis decreases ferritin, transferrin and vitamin B12, Which may cause anemia in serially treated patients. Ther Apher Dial, 14(2): 136-42.
Luers C, Wachter R, Kleta S, Uhlir M, Koschack J, Scherer M, Binder L, Herrmann-Lingen C, Zapf A, Kulle B, Kochen MM, Pieske B (2010). Natriuretic peptides in the detection of preclinical diastolic or systolic dysfunction. Clin Res Cardiol, 99(4):217-26.
Hagenah G, Zapf A, Schüttert JB (2009). Cheyne-Stokes Respiration and Prognosis in Modern-Treated Congestive Heart Failure. Lung, 188(4): 309-13.
Koziolek MJ, Müller GA, Zapf A, Patschan D, Schmid H, Cohen CD, Koschnick S, Vasko R, Bramlage C, Strutz F (2009). Role of CX3C-L/fractalkine expression in a model of slowly progressive renal failure. Nephrol Dial Transplant, 25(3): 684-98.
Bramlage CP, Schröder K, Bramlage P, Ahrens K, Zapf A, Müller GA, Koziolek MJ (2009). Predictors of complications in therapeutic plasma exchange. J Clin Apher, 24(6):225-31.
Mitteldorf C, Bertsch HP, Zapf A, Neumann C, Kretschmer L (2009). Cutting a sentinel lymph node into slices is the optimal first step for examination of sentinel lymph nodes in melanoma patients. Mod Pathol, 22(12):1622-7.
Bramlage CP, Schlumbohm C, Pryce CR, Mirza S, Schnell C, Amann K, Armstrong VW, Eitner F, Zapf A, Feldon J, Oellerich M, Fuchs E, Müller GA, Strutz F (2009). Prenatal dexamethasone exposure does not alter blood pressure and nephron number in the young adult marmoset monkey (2009). Hypertension, 54(5):1115-22.
Kertest T, Hermann MK, Zapf A, Christiansen H, Hermann RM, Pradier O, Schmidberger H, Hess CF, Hille A (2009). Effect of prostaglandin - given rectally for prevention of radiation-induced acute proctitis - on late rectal toxicity. Results of a phase III randomized, placebo-controlled, double-blind study. Strahlenther Onkol, 185(9):596-602.
Hahn W, Dathe H, Fialka-Fricke J, Fricke-Zech S, Zapf A, Kubein-Meesenburg D, Sadat-Khonsari R (2009). Influence of thermoplastic appliance thickness on the magnitude of force delivered to a maxillary central incisor during tipping. Am J Orthod Dentofacial Orthop, 136(1)12.e1-7; discussion 12-3.
Hahn W, Fialka-Fricke J, Dathe H, Fricke-Zech S, Zapf A, Gruber R, Kubein-Meesenburg D, Sadat-Khonsari R (2009). Initial forces generated by three types of thermoplastic appliances on an upper central incisor during tipping. Eur J Orthod, 31(6):625-13.
Hahn W, Fricke-Zech S, Fialka-Fricke J, Dullin C, Zapf A, Gruber R, Sennhenn-Kirchner S, Kubein-Meesenburg D, Sadat-Khonsari R (2009). Imaging of the midpalatal suture in a porcine model: Flat-panel volume computed tomography compared with multislice computed tomography. Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 108(3):443-9.
Bachmann CG, Zapf A, Brunner E, Trenkwalder C (2009). Dopaminergic treatment is associated with decreased body weight in patients with Parkinson's disease and dyskinesias. Eur J Neurol, 16(8):895-901.
Pavlakovic G, Züchner K, Zapf A, Bachmann CG, Graf BM, Crozier TA, Pavlakovic H (2009). Influence of intrinsic noise generated by a thermotesting device on thermal sensory detection and thermal pain detection thresholds. Muscle Nerve, 40(2):257-63.
Drengk A, Zapf A, Stürmer EK, Stürmer KM, Frosch KH (2009). Influence of Platelet-Rich Plasma on Chondrogenic Differentiation and Proliferation of Chondrocytes and Mesenchymal Stem Cells. Cells Tissues Organs, 189(5):317-26.
Hahn W, Fricke-Zech S, Fricke J, Gruber RM, Dullin C, Zapf A, Hannig C, Kubein-Meesenburg D, Sadat-Khonsari R (2009). Detection and size differentiation of simulated tooth root defects using flat-panel volume computerized tomography (fpVCT). Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 107(2):272-8.
Pavlakovic G,Klinke I, Pavlakovic H, Züchner K, Zapf A, Bachmann CG, Graf BM, Crozier TA (2008). Effect of thermode application pressure on thermal detection. Muscle Nerve, 38(5):1498-505.
Hahn W, Fricke J, Fricke-Zech S, Zapf A, Gruber R, Sadat-Khonsari R (2008). The use of a neodymium–iron–boron magnet device for positioning a multi-stranded wire retainer in lingual retention—a pilot study in humans. Eur J Orthod., 30(5):433-6.
Chapuy B, Koch R, Radunski U, Corsham S, Cheong N, Inagaki N, Ban N, Wenzel D, Reinhardt D, Zapf A, Schweyer S, Kosari F, Klapper W, Truemper L, Wulf GG (2008). Intracellular ABC transporter A3 confers multidrug resistance in leukemia cells by lysosomal drug sequestration. Leukemia, 22(8):1576-86.
Koziolek MJ, Schmid H, Cohen CD, Blaschke S, Hemmerlein B, Zapf A, Müller GA, Strutz F (2007). Potential role of fractalkine receptor expression in human renal fibrogenesis. Kidney Int, 72(5):599-607.