Institut für Medizinische Statistik - UMG



  1. S. Wandel, B. Neuenschwander, T. Friede, C. Röver. (2016) Using phase II data for the analysis of phase III studies: an application in rare diseases. (submitted for publication) [Abstract]
  2. Mütze T, Friede T (2016). Blinded sample size re-estimation in three-arm trials with 'gold standard' design. (Submitted for publication). [Preprint]
  3. Mütze T, Schmidli H, Friede T (2017). Nuisance parameter based sample size re-estimation incorporating prior information. (Submitted for publication). [Preprint]

Im Druck

  1. Gold SM, Enck P, Hasselmann H, Friede T, Hegerl U, Mohr DC, Otto C (2017) Control conditions for randomized trials of behavioral interventions in psychiatry: A decision framework. Lancet Psychiatry (in press).
  2. Stellmann JP, Krumbholz M, Friede T, Gahlen A, Borisow N, Fischer K, Hellwig, Pache F, Ruprecht K, Havla J, Kümpfel T, Aktas O, Hartung HP, Ringelstein M, Geis C, Kleinschnitz C, Berthele A, Hemmer B, Angstwurm K, Young KL, Schuster S, Stangel M, Lauda F, Tumani H, Mayer C, Zeltner L, Ziemann U, Linker RA, Schwab M, Marziniak M, Then Bergh F, Hofstadt-van Oy U, Neuhaus O, Zettl U, Faiss J, Wildemann B, Paul F, Jarius S, Trebst C, Kleiter I on behalf of NEMOS (Neuromyelitis Optica Study Group) (2017) Immunotherapies in neuromyelitis optica spectrum disorder: Efficacy and predictors of response. Journal of Neurology, Neurosurgery and Psychiatry (in press).
  3. Seegers J, Hnatkova K, Friede T, Malik M, Zabel M (2017) T-wave loop area from a pre-implant 12-lead ECG is associated with appropriate ICD shocks. PLOS ONE (in press).
  4. Brunner, E., Konietschke, F., Pauly, M., and Puri, M.L. (2017). Rank-Based Procedures in Factorial Designs: Hypotheses about Nonparametric Treatment Effects. Journal of the Royal Statistical Society Series B, (accepted for Publication). DOI: 10.1111/rssb.12222 [Supporting information] 
  5. Messroghli DR, Pickardt T, Fischer M, Opgen-Rhein B, Papakostas K, Böcker D, Jakob A, Khalil M, Mueller GC, Schmidt F, Kaestner M, Udink ten Cate FEA, Wagner R, Ruf B, Kiski D, Wiegand G, Franziska Degener F, Bauer UMM, Friede T, Schubert S on behalf of the MYKKE consortium (2017) Towards evidence-based diagnosis and therapy of myocarditis in children and adolescents: Rationale, design, and first baseline data of MYKKE, a multi-centre registry and study platform. The American Heart Journal (in press).
  6. Wandel S, Neuenschwander B, Röver C, Friede T (2017) Using phase II data for the analysis of phase III studies: an application in rare diseases. Clinical Trials (in press).
  7. Placzek M, Friede T (2017) Clinical trials with nested subgroups: Analysis, sample Size determination and internal pilot studies. Statistical Methods in Medical Research (in press).
  8. Jo P, Nietert M, Gusky L, Kitz J, Conradi LC, Müller-Dornieden A, Schüler P, Wolff HA, Rüschoff J, Ströbel P, Grade M, Liersch T, Beißbarth T, Ghadimi MB, Sax U, Gaedcke J. (2016) Neoadjuvant Therapy in Rectal Cancer - Biobanking of Preoperative Tumor Biopsies. Sci Rep. 2016 Oct 18;6:35589. doi: 10.1038/srep35589.
  9. Linke F, Harenberg M, Nietert MM, Zaunig S, von Bonin F, Arlt A, ... Beißbarth T et al. (2016) Microenvironmental interactions between endothelial and lymphoma cells—a role for the canonical WNT pathway in Hodgkin lymphoma. Leukemia. 2016 Oct 4. doi: 10.1038/leu.2016.232. [Epub ahead of print] [Abstract] 
  10. Linke F, Zaunig S, Nietert MM, von Bonin F, Lutz S, Dullin C, ...Beißbarth T et al. (2017) WNT5A: a motility-promoting factor in Hodgkin lymphoma. Oncogene. 2017 Jan 5;36(1):13-23. doi: 10.1038/onc.2016.183. [Abstract] 
  11. Unkel, S. (2016) On the shape of the cross-ratio function in bivariate survival models induced by truncated and folded normal frailty distributions, Metrika. In press, doi:10.1007/s00184-016-0608-6
  12. Unkel, S. (2016) On the conditional probability for assessing time dependence of association in shared frailty models with bivariate current status data. Journal of Statistical Planning and Inference, in press [Abstract] 
  13. Filippatos GS, de Graeff P, Bax JJ, Borg JJ, Cleland JGF, Dargie HJ, Flather M, Ford I, Friede T, Greenberg B, Henon-Goburdhun C, Holcomb R, Horst B, Lekakis J, Mueller-Velten G, Papavassiliou AG, Prasad K, Rosano GMC, Severin T, Sherman W, Gattis Stough W, Swedberg K, Tavazzi L, Tousoulis D, Vardas P, Ruschitzka F, Anker SD (2017) Independent Academic Data Monitoring Committees for Clinical Trials in Cardiovascular and Cardiometabolic Diseases. European Heart Failure Journal (in press).
  14. Balcarek P, Rehn S, Howells NR, Eldridge JD, Kita K, Dejour D, Nelitz M, Harden M, Friede T (2016) Results of Trochleoplasty versus Medial Patellofemoral Ligament Reconstruction in Patellar Instability caused by severe Trochlear Dysplasia - A Systematic Review and Meta-Analysis. Knee Surgery, Sports Traumatology, Arthroscopy (in press).
  15. Schmidli H, Neuenschwander B, Friede T (2016) Meta-analytic-predictive use of historical variance data for the design and analysis of clinical trials. Computational Statistics & Data Analysis (in press).
  16. Friede T, Röver C, Wandel S, Neuenschwander B (2016) Meta-analysis of two studies in the presence of heterogeneity with applications in rare diseases. Biometrical Journal (in press) [Abstract]
  17. Gross O, Kashtan CE, Rheault M, Flinter F, Savige J, Miner JH, Torra R, Ars E, Deltas C, Savva I, Perin L, Renieri A, Ariani F, Mari F, Baigent C, Judge P, Knebelman B, Heidet L, Lagas S, Blatt D, Ding J, Zhang Y, Gale1 DP, Prunotto M, Xue Y, Schachter AD, Morton LCG, Blem J, Huang M, Liu S, Vallee S, Renault D, Schifter J, Skelding J, Gear S, Friede T, Turner AN, Lennon R (2016) Advances and Unmet Needs in Genetics, Basic and Clinical Science in Alport syndrome: Report from the 2015 International Workshop on Alport Syndrome. Nephrology Dialysis Transplantation (in press).
  18. Körner S, Böselt S, Wichmann K, Thau-Habermann N, Zapf A, Knippenberg S, Dengler R, Petri S (2016) The Axon Guidance Protein Semaphorin 3A Is Increased in the Motor Cortex of Patients With Amyotrophic Lateral Sclerosis. J Neuropathol Exp Neurol [Epub ahead of print]. [Abstract]
  19. Rinke S, Roediger M, Eickholz P, Lange K, Ziebolz D. (2014) Technical and biological complications of single-molar implant restorations. Clinical Oral Implants Research [in press]


  1. Varges D, Manthey H, Heinemann U, Ponto C, Schmitz M, Krasnianski A, Breithaupt M, Fincke F, Kramer K, Friede T, Zerr I (2016) Doxycycline in early CJD – double-blinded randomized phase II and observational study. Journal of Neurology, Neurosurgery & Psychiatry 88: 119–125. [Open Access]
  2. Ursino M, Zohar S, Lentz F, Alberti C, Friede T, Stallard N, Comtes E (2017) Dose-finding methods using pharmacokinetics in small populations. Biometrical Journal. [Open Access].
  3. Kunz CU, Stallard N, Parsons N, Todd S, Friede T (2016) Blinded versus unblinded estimation of a correlation coefficient to inform interim design adaptations. Biometrical Journal 2: 344–357. [Open Access].
  4. Wegscheider K, Friede T (2017) Do we consent to rules of consent and confidentiality? Biometrical Journal 2: 235–239.
  5. Friede T, Röver C, Wandel S, Neuenschwander B (2017) Meta-analysis of few small studies in orphan diseases. Research Synthesis Methods 8: 79–91. [Open Access].
  6. Röver C, Friede T (2017) Discrete approximation of a mixture distribution via restricted divergence. Journal of Computational and Graphical Statistics 26(1):217-222. [Abstract] .
  7. Mütze T, Konietschke F, Munk A, Friede T (2017) A studentized permutation test for three-arm trials in the ‘gold standard’ design. Statistics in Medicine 36: 883–898. [Abstract] 
  8. Bodnar, O., Link, A., Arendacká, B., Possolo, A., and Elster, C. (2017) Bayesian estimation in random effects meta-analysis using a non-informative prior. Statist. Med., 36: 378–399. doi:10.1002/sim.7156 [Abstract].
  9. Dango S, Beißbarth T, Weiss E, Seif Amir Hosseini A, Raddatz D, Ellenrieder V, Lotz J, Ghadimi BM, Beham A. (2017) Relevance of surgery in patients with non-variceal upper gastrointestinal bleeding. Langenbecks Arch Surg. 2017 Jan 14. epub. [Abstract]
  10. Kramer F, Beißbarth T. (2017) Working with Ontologies. Methods Mol Biol. 2017;1525:123-135. [Abstract]


  1. Nikolin, V.M., Olarte-Castillo, X.A., Osterrieder, N., Hofer, H., Dubovi, E., Mazzoni, C.J., Brunner, E., Goller, K.V., Fyumagwa, R.D., Moehlman, P.D., Thierer, D., and East, M.L. (2016) Canine distemper virus in the Serengeti ecosystem: molecular adaptation to different carnivore species. Molecular Ecology, doi: 10.1111/mec.13902
  2. Friedrich, S., Brunner, E., and Pauly, M. (2016) Permuting longitudinal data despite of the dependencies. Journal of Multivariate Analysis, Available online 25 October 2016, [Abstract]
  3. Sprenger T, Rothe H, Conradi LC, Beissbarth T, Kauffels A, Kitz J, Homayounfar K, Wolff H, Ströbel P, Ghadimi M, Wittekind C, Sauer R, Rödel C, Liersch T. (2016) Stage-Dependent Frequency of Lymph Node Metastases in Patients With Rectal Carcinoma After Preoperative Chemoradiation: Results from the CAO/ARO/AIO-94 Trial and From a Comparative Prospective Evaluation With Extensive Pathological Workup. Dis Colon Rectum. 2016 May;59(5):377-85. [Abstract]
  4. Wlochowitz D, Haubrock M, Arackal J, Bleckmann A, Wolff A, Beißbarth T, Wingender E, Gültas M. (2016) Computational Identification of Key Regulators in Two Different Colorectal Cancer Cell Lines. Front Genet. 2016 Apr 5;7:42. [Abstract]
  5. Azizian A, Epping I, Kramer F, Jo P, Bernhardt M, Kitz J, Salinas G, Wolff HA, Grade M, Beißbarth T, Ghadimi BM, Gaedcke J. (2016) Prognostic Value of MicroRNAs in Preoperative Treated Rectal Cancer. Int J Mol Sci. 2016 Apr 15;17(4):568 [Abstract]
  6. Sprenger T, Rothe H, Beissbarth T, Conradi LC, Kauffels A, Homayounfar K, Behnes CL, Rödel C, Liersch T, Ghadimi M. (2016) Lymph node metastases in ypT1/2 rectal cancer after neoadjuvant chemoradiotherapy : The Achilles heel of organ-preserving operative procedures? Chirurg. 2016 Jul;87(7):593-601. [Abstract]
  7. Kruppa J, Kramer F, Beißbarth T, Jung K. (2016) A simulation framework for correlated count data of features subsets in high-throughput sequencing or proteomics experiments. Stat Appl Genet Mol Biol. 2016 Oct 1;15(5):401-414. [Abstract]
  8. Sahlmann CO, Homayounfar K, Niessner M, Dyczkowski J, Conradi LC, Braulke F, Meller B, Beißbarth T, Ghadimi BM, Meller J, Goldenberg DM, Liersch T. (2016) Repeated adjuvant anti-CEA radioimmunotherapy after resection of colorectal liver metastases: Safety, feasibility, and long-term efficacy results of a prospective phase 2 study. Cancer, 2016 Oct 20, epub [Abstract]
  9. B. P. Abbott..., C. Röver et al. (2016) Properties of the binary black hole merger GW150914. Physical Review Letters, 116(24):241102, 2016. [Abstract]
  10. B. P. Abbott..., C. Röver et al. (2016) Improved analysis of GW150914 using a fully spin-precessing waveform model. Physical Review X, 6(4):041014, 2016. [Abstract]
  11. Metz I, Beißbarth T, Ellenberger D, Pache F, Stork L, Ringelstein M, Aktas O, Jarius S, Wildemann BT, Dihazi H, Friede T, Brück W, Ruprecht K, Paul F (2016) Serum peptide reactivities may distinguish neuromyelitis optica subgroups and multiple sclerosis.Neurology: Neuroimmunology & Neuroinflammation April 2016 vol. 3 no. 2 e204. [Full Text]
  12. Schroeter MR, Köhler H, Wachter A, Bleckmann A, Hasenfuß G, Schillinger W (2016) Use of the Impella Device for Acute Coronary Syndrome Complicated by Cardiogenic Shock - Experience From a Single Heart Center With Analysis of Long-term Mortality. J Invasive Cardiol. 2016 Dec;28(12):467-472. Epub 2016 Aug 15.#
  13. Brockmeyer P, Krohn S, Thiemann C, Schulz X , Kauffmann P, Tröltzsch M, Schlottig F, Schliephake H, Gruber RM (2016) Primary stability and osseointegration of dental implants in polylactide modified bone - A pilot study in Goettingen minipigs. Journal of Cranio-Maxillofacial Surgery 2016 Aug; 44 (8): 1095-1103. [Abstract]
  14. Herold S, Kumar P, Jung K, Graf I, Menkhoff H, Schulz X , Bähr M, Hein K (2016) CatWalk gait analysis in a rat model of multiple sclerosis. BMC Neuroscience 2016; 17: 78. [Abstract]
  15. Broekaert SM, Böer-Auer A, Kerl K, Herrgott I, Schulz X , Bonsmann G, Brehler R, Metze D (2016) Neutrophilic Epitheliotropism Is a Histapathological Clue to Neutrophilic Urticarial Dermatosis. The American Journal of Dermatopathology 2016; 38(1): 39-49. [Abstract]
  16. Karch A, Koch A, Zapf A, Zerr I, Karch A. (2016) Partial verification bias and incorporation bias affected accuracy estimates of diagnostic studies for biomarkers that were part of an existing composite gold standard. J Clin Epidemiol. 2016 Oct;78:73-82. doi: 10.1016/j.jclinepi.2016.03.022. [Abstract]
  17. Förster J, Ahlenstiel-Grunow T, Zapf A, Mynarek M, Pape L (2016). Pubertal development in pediatric kidney transplant patients receiving mammalian target of Rapamycin inhibitors or conventional immunosuppression. Transplantation 2016 Nov;100(11):2461-2470. [Abstract]
  18. Straube S, Harden M, Schröder H, Arendacka B, Fan X, Moore A, Friede T (2016) Back schools for the treatment of chronic low back pain: possibility of benefit but no convincing evidence after 47 years of research – systematic review and meta-analysis. Pain 157: 2160–2172. [Open Access]
  19. Seegers J, Conen D, Jung K, Bergau L, Dorenkamp M, Munoz Exposito P, Lüthje L, Sohns C, Sossalla ST, Fischer TH, Hasenfuss G, Friede T, Zabel M (2016) Sex difference in appropriate shocks but not mortality during long-term follow-up in patients with implantable cardioverter-defibrillators. EP Europace 18, 1194–1202.
  20. Olthoff A, Carstens PO, Zhang S, von Fintel E, Friede T, Lotz J, Frahm J, Schmidt J (2016) Evaluation of dysphagia by novel real-time magnetic resonance imaging. Neurology 87: 2132-2138.
  21. Patel S, Hee SW, Mistry D, Jordan J, Brown S, Dritsaki M, Ellard DR, Friede T, Lamb SE, Lord J, Madan J, Morris T, Stallard N, Colin Tysall, Adrian Willis, Underwood M and the Repository Group (2016) Identifying back pain subgroups: developing and applying approaches using individual patient data collected within clinical trials. Programme Grants for Applied Research 4 (10). [Open Access]
  22. Conen D, Arendacka B, Röver C, Bergau L, Munoz P, Wijers S, Sticherling C, Zabel M, Friede T (2016) Gender differences in appropriate shocks and mortality among patients with primary prophylactic implantable cardioverter-defibrillators: Systematic review and meta-analysis. PLoS ONE 11(9):e0162756. [Abstract]
  23. Zapf A, Castell S, Morawietz L, Karch A. (2016) Measuring inter-rater reliability for nominal data - which coefficients and confidence intervals are appropriate? BMC Med Res Methodol. 2016 Aug 5;16:93. doi: 10.1186/s12874-016-0200-9. [Abstract]
  24. Ellenberger D, Friede T (2016) An unconditional test for change point detection in binary sequences with applications to clinical registries. Methods of Information in Medicine 55: 367–372. [Abstract]
  25. Nicotra A, Claus Newman C, Eremin O, Friede T, Malik O, Nicholas R (2016) Peripheral nerve dysfunction in middle-aged subjects born with thalidomide embryopathy. PLoS ONE 11(4): e0152902. doi:10.1371/journal.pone.0152902 [Open Access]
  26. Seegers J, Bergau L, Muñoz Expósito P, Bauer A, Fischer T, Lüthje L, Hasenfuß G, Friede T, Zabel M (2016) Prediction of appropriate shocks using 24-hour holter variables and T-wave alternans following first implantable cardioverter-defibrillator implantation in patients with ischemic and non-ischemic cardiomyopathy. American Journal of Cardiology 118: 86-94. [Open Access]
  27. Sudlow R, Branson J, Friede T, Morgan D, Whately-Smith C (2016) EFSPI/PSI Working Group on Data Sharing: Accessing and Working with Pharmaceutical Clinical Trial Patient Level Datasets – a Primer for Academic Researchers. BMC Medical Research Methodology 16 (Suppl 1): 73. [Open Access]
  28. Chataway J, Friede T (2016) The N-MOmentum trial: building momentum to advance trial methodology in a rare disease. Multiple Sclerosis Journal 22: 852–853.
  29. Sterz C, Ellenberger D, Meissner H, Friede T, Flachenecker P (2016) Employment-associated factors in multiple sclerosis – results of a cross sectional study in Germany. Edorium Journal of Disability and Rehabilitation 2: 24–33. [Open Access]
  30. Latif, A.H.M. and Brunner, E. (2016) A genetic Algorithm for designing microarray experiments. Comput. Stat.31, 409-424. doi:10.1007/s00180-015-0618-2
  31. Rave-Fränk M, Tehrany N, Kitz J, Leu M, Weber HE, Burfeind P, Schliephake H, Canis M, Beissbarth T, Reichardt HM, Wolff HA. (2016) Prognostic value of CXCL12 and CXCR4 in inoperable head and neck squamous cell carcinoma. Strahlenther Onkol. 2016 Jan;192(1):47-54. [Abstract]
  32. von der Heyde S, Sonntag J, Kramer F, Bender C, Korf U, Beißbarth T. (2016) Reconstruction of Protein Networks Using Reverse-Phase Protein Array Data. Methods Mol Biol. 2016;1362:227-46. [Abstract]
  33. Tomas-Roig J, Piscitelli F, Gil V, Del Río JA, Moore TP, Agbemenyah H, Salinas-Riester G, Pommerenke C, Lorenzen S, Beißbarth T, Hoyer-Fender S, Di Marzo V, Havemann-Reinecke U. (2016) Social defeat leads to changes in the endocannabinoid system: An overexpression of calreticulin and motor impairment in mice. Behav Brain Res. 2016 Apr 15;303:34-43. [Abstract]
  34. Bleckmann A, Conradi LC, Menck K, Schmick NA, Schubert A, Rietkötter E, Arackal J, Middel P, Schambony A, Liersch T, Homayounfar K, Beißbarth T, Klemm F, Binder C, Pukrop T. (2016) Beta-catenin-independent WNT signaling and Ki67 in contrast to the estrogen receptor status are prognostic and associated with poor prognosis in breast cancer liver metastases. Clin Exp Metastasis. 2016 Apr;33(4):309-23. [Abstract]
  35. Wachter A and Beißbarth T (2016) Decoding Cellular Dynamics in Epidermal Growth Factor Signaling Using a New Pathway-Based Integration Approach for Proteomics and Transcriptomics Data. Front. Genet. 2016 Jan 7; 6:351. [Abstract]
  36. Pickenbrock H, Diel A, Zapf A (2016) A comparison between the Static Balance Test and the Berg Balance Scale: Validity, reliability, and comparative resource use. Clinical rehabilitation, 30(3):288-293.
  37. Unkel S, Röver C, Stallard N, Benda N, Posch M, Zohar S, Friede T (2016) Systematic reviews in paediatric multiple sclerosis and Creutzfeldt-Jakob disease exemplify shortcomings in methods used to evaluate therapies in rare conditions. Orphanet Journal of Rare Diseases 11:16. [Open access]
  38. Mütze T, Munk A, Friede T (2016) Design and analysis of three-arm trials with negative binomially distributed endpoints. Statistics in Medicine 35: 505–521.
  39. Unkel, S., Belka, C. and Lauber, K. (2016) On the analysis of clonogenic survival data: Statistical alternatives to the linear-quadratic model, Radiation Oncology, 11:11. [Open access]
  40. Ondra T, Dmitrienko A, Friede T, Graf A, Miller F, Stallard N, Posch M (2016) Methods for identification and confirmation of targeted subgroups in clinical trials: A systematic review. Journal of Biopharmaceutical Statistics 26: 99-119. [Open access]
  41. Röver C, Andreas S, Friede T (2016) Evidence synthesis for count distributions based on heterogeneous and incomplete aggregated data. Biometrical Journal 58(1):170-185, 2016. [Abstract]


  1. Pauly, M., Ellenberger, D., and Brunner, E. (2015) Analysis of High-Dimensional One Group Repeated Measures Designs. Statistics 2015; 49(6): 1243–1261
  2. Dirk Dressler, Chrisanthi Karapantzou, Saskia Rohrbach, Simon Schneider, Rainer Laskawi (2015) Frontalis suspension surgery to treat patients with blepharospasm and eyelid opening apraxia: long-term results. J Neural Transm DOI 10.1007/s00702-016-1641-3.
  3. Mollenhauer B, Zimmermann J, Sixel-Döring F, Focke NK, Wicke T, Ebentheuer J, Schaumburg M, Lang E, Trautmann E, Zetterberg H, Taylor P, Friede T, Trenkwalder C & the DeNoPa Study Group (2015) Monitoring of thirty marker candidates in early Parkinson’s disease as progression markers. Neurology 87: 168-77.
  4. Helms HJ, Benda N, Friede T (2015) Point and interval estimators of the target dose in clinical dose-finding studies with active control. Journal of Biopharmaceutical Statistics 25: 939–957. [Open Access]
  5. Koschack J, Weibezahl L, Friede T, Himmel W, Makedonski P, Grabowski J (2015) Scientific versus experiential evidence: Discourse analysis of the CCSVI debate in a multiple sclerosis forum. Journal of Medical Internet Research 17(7): e159 doi:10.2196/jmir.4103.
  6. Jackson N, Atar D, Maria Borentain M, Breithardt G, van Eickels M, Endres M, Fraass U, Friede T, Hannachi H, Janmohamed S, Kreuzer J, Landray M, Lautsch D, Le Floch C, Moll P, Naci1 H, Samani1 NJ, Svensson A, Thorstensen C, Tijssen J, Vandzhura V, Zalewski A, Kirchhof P (2015) Improving clinical trials for cardiovascular diseases: a position paper from the Cardiovascular Round Table of the European Society of Cardiology. European Heart Journal 37(9):747-54.
  7. Kramer D, Schön M, Bayerlová M, Bleckmann A, Schön MP, Zörnig M, Dobbelstein M. (2015) A pro-apoptotic function of iASPP by stabilizing p300 and CBP through inhibition of BRMS1 E3 ubiquitin ligase activity. Cell Death Dis. 2015 Feb 12;6:e1634.
  8. Rietkötter E, Bleckmann A, Bayerlová M, Menck K, Chuang HN, Wenske B, Schwartz H, Erez N, Binder C, Hanisch UK, Pukrop T. (2015) Anti-CSF-1 treatment is effective to prevent carcinoma invasion induced by monocyte-derived cells but scarcely by microglia. Oncotarget. 2015 Jun 20;6(17):15482-93.
  9. Annabell Bischoff A, Bayerlová M, Strotbek M, Schmid S, Beißbarth T, Olayioye MA (2015) A global microRNA screen identifies regulators of the ErbB receptor signaling network Cell Communication and Signaling, 2015, 3:5. [Abstract]
  10. Srinivas US, Dyczkowski J, Beißbarth T, Gaedcke J, Mansour WY, Borgmann K, Dobbelstein M. (2015) 5-Fluorouracil sensitizes colorectal tumor cells towards double stranded DNA breaks by interfering with homologous recombination repair. Oncotarget. 2015 May 20;6(14):12574-86. [Abstract]
  11. Styczen H, Nagelmeier I, Beissbarth T, Nietert M, Homayounfar K, Sprenger T, Boczek U, Stanek K, Kitz J, Wolff HA, Ghadimi BM, Middel P, Liersch T, Rüschoff J, Conradi LC. (2015) HER-2 and HER-3 expression in liver metastases of patients with colorectal cancer.Oncotarget. 2015 Jun 20;6(17):15065-76. [Abstract]
  12. Azizian A, Kramer F, Jo P, Wolff HA, Beißbarth T, Skarupke R, Bernhardt M, Grade M, Ghadimi BM, Gaedcke J. (2015) Preoperative Prediction of Lymph Node Status by Circulating Mir-18b and Mir-20a During Chemoradiotherapy in Patients with Rectal Cancer. World J Surg. 2015 Sep;39(9):2329-35. [Abstract]
  13. Mansur A, Mulwande E, Steinau M, Bergmann I, Popov AF, Ghadimi M, Beissbarth T, Bauer M, Hinz J. (2015) Chronic kidney disease is associated with a higher 90-day mortality than other chronic medical conditions in patients with sepsis. Sci Rep. 2015 May 21;5:10539. [Abstract]
  14. Mansur A, Liese B, Steinau M, Ghadimi M, Bergmann I, Tzvetkov M, Popov AF, Beissbarth T, Bauer M, Hinz J. (2015) The CD14 rs2569190 TT Genotype Is Associated with an Improved 30-Day Survival in Patients with Sepsis: A Prospective Observational Cohort Study. PLoS One. 2015 May 28;10(5):e0127761. [Abstract]
  15. Becker K, Stauber M, Schwarz F, Beißbarth T. (2015) Automated 3D-2D registration of X-ray microcomputed tomography with histological sections for dental implants in bone using chamfer matching and simulated annealing. Comput Med Imaging Graph. 2015 Sep;44:62-8. [Abstract]
  16. Mansur A, Steinau M, Popov AF, Ghadimi M, Beissbarth T, Bauer M, Hinz J. (2015) Impact of statin therapy on mortality in patients with sepsis-associated acute respiratory distress syndrome (ARDS) depends on ARDS severity: a prospective observational cohort study. BMC Med. 2015 Jun 1;13:128. [Abstract]
  17. Mansur A, Steinau M, Popov AF, Milenovic S, Bireta C, Weymann A, Schotola H, Wiese CH, Beissbarth T, Tzvetkov M, Hinz J. (2015) Genetic Polymorphisms in Endothelin-1 as Predictors for Long-Term Survival and the Cardiac Index in Patients Undergoing On-Pump Cardiac Surgery. PLoS One. 2015 Jun 29;10(6):e0131155. [Abstract]
  18. Zhang X, Schulz R, Edmunds S, Krüger E, Markert E, Gaedcke J, Cormet-Boyaka E, Ghadimi M, Beissbarth T, Levine AJ, Moll UM, Dobbelstein M. (2015) MicroRNA-101 Suppresses Tumor Cell Proliferation by Acting as an Endogenous Proteasome Inhibitor via Targeting the Proteasome Assembly Factor POMP. Mol Cell. 2015 Jul 16;59(2):243-57. [Abstract]
  19. Lüddecke S, Ertych N, Stenzinger A, Weichert W, Beissbarth T, Dyczkowski J, Gaedcke J, Valerius O, Braus GH, Kschischo M, Bastians H. (2015) The putative oncogene CEP72 inhibits the mitotic function of BRCA1 and induces chromosomal instability. Oncogene. 2015 Aug 24. [Abstract]
  20. Bayerlová M, Jung K, Kramer F, Klemm F, Bleckmann A, Beißbarth T. (2015) Comparative study on gene set and pathway topology-based enrichment methods. BMC Bioinformatics. 2015 Oct 22;16:334. [Abstract]
  21. Mansur A, Popov AF, Hanna AA, Bergmann I, Brandes IF, Beißbarth T, Bauer M, Hinz J. (2015) Perioperative Blood Glucose Levels?<150?mg/dL are Associated With Improved 5-Year Survival in Patients Undergoing On-Pump Cardiac Surgery: A Prospective, Observational Cohort Study. Medicine (Baltimore). 2015 Nov;94(45):e2035. [Abstract]
  22. Bayerlova M, Klemm F, Kramer F, Pukrop T, Beißbarth , Bleckmann A. (2015) Newly Constructed Network Models of Different WNT Signaling Cascades Applied to Breast Cancer Expression Data. PLoS One. 2015 Dec 3;10(12):e0144014. [Abstract]
  23. Wu Y, Lee SH, Williamson EA, Reinert BL, Cho JH, Xia F, Jaiswal AS, Srinivasan G, Patel B, Brantley A, Zhou D, Shao L, Pathak R, Hauer-Jensen M, Singh S, Kong K, Wu X, Kim HS, Beißbarth T, Gaedcke J, Burma S, Nickoloff JA, Hromas RA. (2015) EEPD1 Rescues Stressed Replication Forks and Maintains Genome Stability by Promoting End Resection and Homologous Recombination Repair. PLoS Genet. 2015 Dec 18;11(12):e1005675. [Abstract]
  24. von der Heyde S, Wagner S, Czerny A, Nietert M, Ludewig F, Salinas-Riester G, Arlt D, Beißbarth T. (2015) mRNA profiling reveals determinants of trastuzumab efficiency in HER2-positive breast cancer. Plos One 2015, 10(2):e0117818. [Abstract]
  25. Pickenbrock HM, Zapf A (equally contributed), Dressler D (2015) Effects of therapeutic positioning on vital parameters in patients with central neurological disorders: a randomised controlled trial. J Clin Nurs, 24(23-24):3681-3690.
  26. Sohns J, Schulte C, Zapf A, Unterberg-Buchwald C, Staab W, Kowallick J, Lauerer P, Nguyen T, Fasshauer M, Paul T, Lotz J, Steinmetz M (2015) Right atrial volume is increased in corrected Tetralogy of Fallot and correlates with the incidence of supraventricular arrhythmia - a CMR study. Pediatric Cardiology, 36(6):1239-47. [Abstract]
  27. Zapf A, Hoyer A, Kramer K, Kuss O (2015) Nonparametric meta-analysis for diagnostic accuracy studies. Statistics in Medicine, 34(29):3831-41. [Abstract]
  28. A. Wachter, T. Beißbarth (2015) pwOmics: An R package for pathway-based integration of time-series omics data using public database knowledge Bioinformatics 2015; 31 (18): 3072-3074. [Abstract]
  29. Wachter, Astrid; Bernhardt, Stephan; Beissbarth, Tim; Korf, Ulrike. (2015) Analysis of Reverse Phase Protein Array Data: From Experimental Design towards Targeted Biomarker Discovery. Microarrays 2015, 4, 520-539. [Abstract]
  30. Straube S, Werny B, Friede T (2015) A systematic review identifies shortcomings in the reporting of cross-over trials in chronic painful conditions. Journal of Clinical Epidemiology 68: 1496-1503. [Open Access ]
  31. C. Röver, G. Knapp, T. Friede. (2015) Hartung-Knapp-Sidik-Jonkman approach and its modification for random-effects meta-analysis with few studies. BMC Medical Research Methodology, 15:99, 2015. DOI: 10.1186/s12874-015-0091-1 [Open Access ]
  32. Brunkhorst LC, Fichtner A, Höcker B, Burmeister G, Ahlenstiel-Grunow T, Krupka K, Bald M, Zapf A, Tönshoff B, Pape L (2015) Efficacy and Safety of an Everolimus- vs. a Mycophenolate Mofetil-Based Regimen in Pediatric Renal Transplant Recipients. PLoS One, 10(9):e0135439. [Abstract]
  33. Zapf A, Gwinner W (equally contributed), Karch A, Metzger J, Haller H, Koch A (2015) Non-invasive diagnosis of acute rejection in renal transplant patients using mass spectrometry of urine samples - a multicentre phase 3 diagnostic accuracy study. BMC Nephrol, 16:153. [Abstract]
  34. Kretschmer L, Bertsch HP, Zapf A, Mitteldorf C, Satzger I, Thoms KM, Völker B, Schön MP, Gutzmer R, Starz H (2015) Nodal Basin Recurrence After Sentinel Lymph Node Biopsy for Melanoma: A Retrospective Multicenter Study in 2653 Patients. Medicine (Baltimore), 94(36):e1433. [Abstract]
  35. Stallard N, Kunz CU, Todd S, Parsons N, Friede T (2015) Flexible selection of a single treatment incorporating short-term endpoint information in a phase II/III clinical trial. Statistics in Medicine 34:3104-3115. [Open Access ]
  36. Schmidt C, Gerlach N, Schmitz M, Thom T, Kramer K, Friede T, Zerr I (2015) Baseline CSF/serum-ratio of apolipoprotein E and rate of differential decline in Alzheimer’s disease. Journal of Alzheimer’s Disease 48: 189–196.
  37. Röver C, Nicholas R, Straube S, Friede T (2015) Changing EDSS progression in placebo cohorts in relapsing MS: A systematic review and meta-regression. PLoS ONE 10(9): e0137052 [Open Access].
  38. Dugas M, Jöckel KH, Friede T, Gefeller O, Kieser M, Marschollek M, Ammenwerth E, R. Röhrig R, Knaup-Gregori P, Prokosch HU (2015) Memorandum “Open Metadata”: Open access to documentation forms and item catalogs in healthcare. Methods of Information in Medicine 54: 376–378. [Open Access]
  39. Ernst, A., Kapfhammer, H., Anders, H., Orth, M., Hennel, R., Seidl, K., Winssinger, N., Belka,C., Unkel, S. and Lauber, K. (2015) HSP90 inhibition as a means of radiosensitizing resistant, aggressive soft tissue sarcomas. Cancer Letters, Vol. 365, Issue 2, pp. 211-222. [Abstract]
  40. Rommer PS, Buckow K, Ellenberger D, Friede T, Pitschnau-Michel D, Fuge J, Stüve O, Zettl UK for the German Multiple Sclerosis (MS) Registry of the German National MS Society (DMSG) (2015) Patients’ characteristics influencing the longitudinal utilization of steroids in multiple sclerosis – an observational study. European Journal of Clinical Investigation 45: 587-593. [Abstract]
  41. Körner S, Kollewe K, Abdulla S, Zapf A, Dengler R, Petri S (2015) Interaction of physical function, quality of life and depression in Amyotrophic lateral sclerosis: characterization of a large patient cohort. BMC Neurol, 15:84. doi: 10.1186/s12883-015-0340-2. [Abstract]
  42. Zapf, A., Brunner, E., and Konietschke, F. (2015) A Wild Bootstrap approach for the selection of biomarkers in early diagnostic trials. BMC Medical Research Methodology. 15(1):43. doi: 10.1186/s12874-015-0025-y. [Abstract]
  43. Schröder M, Stüber V, Walendzik E, O'Loughlin PF, Zapf A, Krettek C, Gaulke R (2015). Establishing an optimal trajectory for calcaneotibial K-wire fixation in emergent treatment of unstable ankle fractures. Technol Health Care. 23(2): 215-21. [Abstract]
  44. Pauly, M., Brunner, E., and Konietschke, F. (2015). Asymptotic Permutation Tests in General Factorial Designs. Journal of the Royal Statistical Society - Series B, 77,461–473. DOI: 10.1111/rssb.12073 [Abstract]
  45. Pickenbrock H, Ludwig VU, Zapf A, Dressler D (2015). Conventional versus neutral positioning in central neurological disease: a multicenter randomized controlled trial. Dtsch Arztebl Int. 2015 Jan 16;112(3):35-42. [Abstract]
  46. Stellmann JP, Stürner KH, Young KL, Siemonsen S, Friede T, Heesen C (2015) Regression to the mean and predictors of MRI disease activity in RRMS placebo cohorts - is there a place for baseline-to-treatment studies in MS? PLoS ONE 10(2): e0116559. doi:10.1371/journal.pone.0116559. [Open Access]
  47. Schmidt C, Gerlach N, Peter C, Gherib K, Lange K, Friede T, Zerr I (2015) CSF Apolipoprotein E Concentration and Progression of Alzheimer's Disease. Journal of Alzheimer’s Disease 43(4): 1229-1236.
  48. Kiessling, J., Leifholz, Unkel, S., Pons-Kühnemann, J. Thunberg, C. and Pedersen, J. N. (2015): A Comparison of Conventional and In-Situ Audiometry on Participants with Varying Levels of Sensorineural Hearing Loss, Journal of the American Academy of Audiology, Vol. 26, pp. 68-79. [Abstract]
  49. Kunz CU, Friede T, Parsons N, Todd S, Stallard N (2015) A comparison of methods for treatment selection in seamless phase II /III clinical trials incorporating information on short-term endpoints. Journal of Biopharmaceutical Statistics 25: 170-189. [Open Access]
  50. Bleckmann A, Leha A, Artmann S, Menck K, Salinas-Riester G, Binder C, Pukrop T, Beißbarth T*, Klemm F*. (2015) Integrated miRNA and mRNA profiling of tumor-educated macrophages identifies prognostic subgroups in estrogen receptor-positive breast cancer. Mol Oncol, 2015, 9(1):155-66 [Abstract]
  51. Tehrany N, Kitz J, Rave-Fränk M, Lorenzen S, Li L, Küffer S, Hess CF, Burfeind P, Reichardt HM, Canis M, Beißbarth T*, Wolff HA*. (2015) High-grade acute organ toxicity and p16INK4A expression as positive prognostic factors in primary radio(chemo)therapy for patients with head and neck squamous cell carcinoma. Strahlenther Onkol2015, 191(7):566-72. [Open Access]
  52. Mansur A, Klee Y, Popov AF, Erlenwein J, Ghadimi M, Beißbarth T, Bauer M, Hinz J. (2015) Primary bacteraemia is associated with a higher mortality risk compared with pulmonary and intra-abdominal infections in patients with sepsis: a prospective observational cohort study. BMJ Open, 2015, 5(1):e006616 [Abstract]
  53. Helms HJ, Benda N, Zinserling J, Kneib T, Friede T (2015) Spline-based procedures for dose-finding studies with active control. Statistics in Medicine 34: 232-248. [Open Access]
  54. Knösel M., Nüser C., Jung K., Helms H.-J., Engelke W. and Sandoval P. (2015) Interactionbetween deglutition, tongue posture, and malocclusion: A comparison of intra-oral compartment formation in subjects with neutral occlusion or different types of malocclusion. The Angle Orthodontist.
  55. Brockmeyer P., Hemmerlein B., Jung K., Fialka F., Brodmann T., Gruber R.M., Schliephake H. and Kramer F.-J. (2015) Connexin subtype expression during oral carcinogenesis: A pilot study in patients with oral squamous cell carcinoma. Molecular and Clinical Oncology. [Abstract]
  56. Haetscher N, Feuermann Y, Wingert S, Rehage M, Thalheimer FB, Weiser C, Bohnenberger H, Jung K, Schroeder T, Serve H, Oellerich T, Henninghausen L and Rieger MA (2015) STAT5-regulated microRNA-193b controls haematopoietic stem and progenitor cell expansion by modulating cytokine receptor signalling. Nature Communications.
  57. Schmidt H., Djukic M., Jung K., Holzgraefe M., Dechent P., von Steinbuechel N., Blocher J., Eiffert H., Schmidt-Samoa C. (2015) Neurocognitive functions and braun atrophy after proven neuroborreliosis: a case-control study. BMC Neurology.
  58. Ganster C., Kämpfe D., Jung K., Shirneshan K., Braulke F., Machherndl-Spandl S., Suessner S., Bramlage C.P., Legler T.J., Koziolek M.J., Haase D., Schanz J. (2015) New data shed light on Y-loss related pathogenesis in MDS. Genes, Chromosomes and Cancer.
  59. Knösel M., Fendel C., Jung K., Sandoval P. and Engelke, W.G. (2015) Pre-surgical orthopedics by drink plates does not significantly improve deviating deglutition in infants with cleft lip and palate. Angle Orthodontist. [Abstract]
  60. Wolf H.A., Ihler F., Zeller N., Welz C., Jung K., Canis M. and Steiner W. (2015) (Chemo)radiotherapy after laser microsurgery and selective neck dissection for pN2 head and neck cancer. European Archives of Oto-Rhino-Laryngology. [Abstract]


  1. Kastl L, Sauer S, Beißbarth T, Becker M, Krammer P, Gülow K. (2014) TNF-a stimulation enhances ROS-dependent cell migration via NF-?B activation in liver cells. Free Radic Biol Med. 2014 Oct;75 Suppl 1:S32. [Abstract]
  2. Konietschke, F., Gel, Y., and Brunner, E. (2014). On multiple contrast tests and simultaneous confidence intervals in high-dimensional repeated measures designs. In: Perspectives of Big Data Analysis (Contemporary Mathematics 622). American Mathematical Society. ISBN 978-1-4704-1042-1, p.109-124. [Abstract]
  3. Engelke W, Glombek J, Psychogios S, Schneider S, Ellenberger D, Santander P. (2014) Displacement of oropharyngeal structures during suction-swallowing cycles. European Archives of Oto-Rhino-Laryngology 271(7), 1987-1997. [Abstract]
  4. Puls M, Tichelbäcker T, Bleckmann A, Hünlich M, von der Ehe K, Beuthner BE, Rüter K, Beißbarth T, Seipelt R, Schöndube F, Hasenfuß G, Schillinger W. (2014) Failure of acute procedural success predicts adverse outcome after percutaneous edge-to-edge mitral valve repair with MitraClip. EuroIntervention, 2014, 9(12):1407-17. h [Abstract]
  5. Hohloch K, Bertram N, Trümper L, Beißbarth T, Griesinger F. (2014) Superior vena cava syndrome caused by a malignant tumor: a retrospective single-center analysis of 124 cases. J Cancer Res Clin Oncol, 2014, 140(12):2129-34. [Abstract]
  6. Mannil M, Solari A, Leha A, Pelayo-Negro AL, Berciano J, Schlotter-Weigel B, Walter MC, Rautenstrauss B, Schnizer TJ, Schenone A, Seeman P, Kadian C, Schreiber O, Angarita NG, Fabrizi GM, Gemignani F, Padua L, Santoro L, Quattrone A, Vita G, Calabrese D; CMT-TRIAAL/CMT-TRAUK Group, Young P, Laurà M, Haberlová J, Mazanec R, Paulus W, Beißbarth T, Shy ME, Reilly MM, Pareyson D, Sereda MW. (2014) Selected items from the Charcot-Marie-Tooth (CMT) Neuropathy Score and secondary clinical outcome measures serve as sensitive clinical markers of disease severity in CMT1A patients. Neuromuscul Disord, 2014, 24(11):1003-17. [Abstract]
  7. Puls M, Sobisiak B, Bleckmann A, Jacobshagen C, Danner BC, Hünlich M, Beißbarth T, Schöndube F, Hasenfuß G, Seipelt R, Schillinger W. (2014) Impact of frailty on short- and long-term morbidity and mortality after transcatheter aortic valve implantation: risk assessment by Katz Index of activities of daily living. EuroIntervention, 2014, 10(5):609-19. [Abstract]
  8. von der Heyde S, Sonntag J, Kaschek D, Bender C, Bues J, Wachter A, Timmer J, Korf U, Beißbarth T (2014) RPPanalyzer toolbox: an improved R package for analysis of reverse phase protein array data. Biotechniques, 2014, 57(3):125-35. [Abstract]
  9. Landmann H, Proia DA, He S, Ogawa LS, Kramer F, Beißbarth T, Grade M, Gaedcke J, Ghadimi M, Moll U, Dobbelstein M. (2014) UDP glucuronosyltransferase 1A expression levels determine the response of colorectal cancer cells to the heat shock protein 90 inhibitor ganetespib. Cell Death Dis, 2014, 5:e1411. [Abstract]
  10. Gaedcke J*, Leha A*, Claus R, Weichenhan D, Jung K, Kitz J, Grade M, Wolff HA, Jo P, Doyen J, Gérard JP, Johnsen SA, Plass C, Beißbarth T, Ghadimi M. (2014) Identification of a DNA methylation signature to predict disease-free survival in locally advanced rectal cancer. Oncotarget, 2014, 5(18):8123-35. [Abstract]
  11. Oberhofer G, Grossmann D, Siemanowski JL, Beißbarth T, Bucher G. (2014) Wnt/ß-catenin signaling integrates patterning and metabolism of the insect growth zone. Development, 2014, 141(24):4740-50. [Abstract]
  12. Silvia von der Heyde, Johanna Sonntag, Daniel Kaschek, Christian Bender, Johannes Bues, Astrid Wachter, Jens Timmer, Ulrike Korf, Tim Beissbarth. (2014) PPanalyzer Toolbox: An improved R package for analysis or reverse phase protein array data. BioTechniques 57 (3): 125-135. [Abstract]
  13. Flachenecker P, Buckow K, Pugliatti M, Bašic Kes V, Battaglia MA, Boyko A, Ellenberger D, Eskic D, Ford D, Friede T, Fuge J, Glaser A, Hillert J, Holloway E, Ioannidou E, Kappos L for the EUReMS Consortium (2014) Multiple sclerosis registries in Europe – results of a systematic survey. Multiple Sclerosis Journal 20: 1523-1532. [Abstract]
  14. Crins ND, Röver C, Goralczyk AD, Friede T (2014) Interleukin-2 Receptor Antagonists for Pediatric Liver Transplant Recipients: A Systematic Review and Meta-Analysis of Controlled Studies. Pediatric Transplantation 18:839-850. [Abstract]
  15. Schmidt C, Becker H, Peter C, Lange K, Friede T, Zerr I (2014) Plasma prion protein concentration and progression of Alzheimer's disease. Prion 8: 12-16. [Abstract]
  16. Schmidt C, Wolff M, von Ahsen N, Lange K, Friede T, Zerr I (2014) CR1 is potentially associated with rate of decline in sporadic Alzheimer's disease. Journal of Clinical Neuroscience 21: 1705-1708. [Abstract]
  17. Vormfelde SV, Abed MA, Hua TD, Schneider S, Friede T, Chenot JF (2014) Schulung oral antikoagulierter Patienten zur Arzneimitteltherapiesicherheit - eine cluster-randomisierte Studie in Hausarztpraxen (Educating orally anticoagulated patients in drug safety – a cluster-randomized study in general practice). Deutsches Ärzteblatt 111(37): 607-614. [Open Access]
  18. Patel S, Ngunjiri A, Hee SW, Yang Y, Brown S, Friede T, Griffiths F, Lord J, Sandhu H, Thistlethwaite J, Tysall C, Underwood M (2014) Primum non nocere: Shared informed decision making in low back pain – A pilot cluster randomised trial. BMC Musculoskeletal Disorders 15: 282. [Open Access]
  19. Brockmeyer P, Lange K, Hahn W, Schliephake H, Matthias Gruber R. (2014) Increase of homogenous new bone formation using osteoinductive factor rhGDF-5 during sinus floor augmentation in Goettingen Minipigs. Clinical Oral Implants Research, 00, 2014, 1–7 (geteilte Erstautorschaft PB und KL)
  20. Rödiger M, Rinke S, Ehret-Kleinau F, Pohlmeyer F, Lange K, Bürgers R, Gersdorff N. (2014) Evaluation of removal forces of implant-supported zirconia copings depending on abutment geometry, luting agent and cleaning method during re-cementation. Journal of Advanced Prosthodontics, 6(3):233-40.
  21. Schmickler J, Wurbs S, Wurbs S, Lange K, Rinke S, Hornecker E, Mausberg RF, Ziebolz D. (2014) Influence of the utilization time of different manual toothbrushes on oral hygiene assessed during a 6-month observation period: a randomized clinical trial. Journal of Periodontology, 85(8):1050-8
  22. Gruber RM, Krohn S, Mauth C, Dard M, Molenberg A, Lange K, Perske C, Schliephake H. (2014) Mandibular reconstruction using a calcium phosphate/polyethylene glycol hydrogel carrier with BMP-2. Journal of Clinical Periodontology, 41(8):820-6.
  23. Herrmann-Lingen C, Brunner E, Hildenbrand S, Loew TH, Raupach T, Spies C, Treede RD, Vahl CF, Wenz HJ. (2014) Evaluation of medical research performance – position paper of the Association of the Scientific Medical Societies in Germany (AWMF). GMS Ger Med Sci. 2014;12:Doc11. DOI: 10.3205/000196, URN: urn:nbn:de:0183-0001969 [Open Access]
  24. Gutenberg A, Nischwitz MD, Gunawan B, Enders C, Jung K, Bergmann M, Feiden W, Egensperger R, Keyvani K, Stolke D, Sure U, Schroeder HWS, Warzok R, Schober R, Meixensberger J, Paulus W, Wassmann H, Stummer W, Blümcke I, Buchfelder M, van Landeghem FKH, Vajkoczy P, Günther M, Bedke J, Giese A, Rohde V, Brück W, Füzesi L and Sander B (2014) Predictive Chromosomal Clusters of Synchronous and Metachronous Brain Metastases in Clear Cell Renal Cell Carcinoma. Cancer Genetics, 207, 206-213.
  25. Brockmeyer P, Jung K, Perske C, Schliephake H and Hemmerlein B (2014) Membrane connexin 43 acts as an independent prognostic marker in oral squamous cell carcinoma. International Journal of Oncology, 45, 273-281.
  26. Rau TT, Agaimy A, Gehoff A, Geppert C, Jung K, Knobloch K, Langner C, Lugli A, Lurkin IG, Nagtegaal I, Rüschoff J, Saegert X, Sarbia M, Schneider-Stock R, Vieth M, Zwarthoff E and Hartmann A (2014) Defined morphological criteria allow reliable diagnosis of colorectal serrated polyps and predict polyp genetics. Virchows Archiv, 464, 663-672.
  27. Mitteldorf C, Bertsch HP, Jung K, Thoms KM, Schön MP, Tronnier M and Kretschmer L (2014) Sentinel Node Biopsy Improves Prognostic Stratification in Patients with Thin (pT1) Melanomas and an Additional Risk Factor. Annals of Surgical Oncology, 21, 2252-2258.
  28. Vollmann D, Woronowicz S, Kmiec L, Jung K, Zenker D, Seegers J, Sossalla S, Dorenkamp M, Sohns C, Lüthje L, Hasenfuss G and Zabel M (2013) Lead Failure Rates and Patient Mortality during Long-Term Follow-Up of Passive Fixation Sprint Fidelis Lead. EP-Europace, 16, 258-264.
  29. Wolf I, Friede T, Hallier E, Straube S (2014) Work-related outcomes in randomised placebo-controlled pain trials: a systematic review and meta-analysis. Journal of Occupational Medicine and Toxicology 9:25. [Open Access]
  30. Kunz CU, Friede T, Parsons N, Todd S, Stallard N (2014) Data-driven treatment selection for seamless phase II/III trials incorporating early-outcome data. Pharmaceutical Statistics 13: 238–246. [Open Access]
  31. Von der Hyde S, Bender C, Henjes F, Sonntag J, Korf U, Beißbarth T. (2014) Boolean ErbB network reconstructions and perturbation simulations reveal individual drug response in different breast cancer cell lines. BMC Systems Biology 2014, 8:75. [Abstract]
  32. Mansur A, von Gruben L, Popov AF, Steinau M, Bergmann I, Ross D, Ghadimi M, Beißbarth T, Bauer M, Hinz J. (2014) The regulatory toll-like receptor 4 genetic polymorphism rs11536889 is associated with renal, coagulation and hepatic organ failure in sepsis patients. J Transl Med, 2014, 12(1):177. [Abstract]
  33. Von der Heyde S, Fromm-Dornieden C, Salinas-Riester G, Beißbarth T, Baumgartner B. (2014) Dynamics of mRNA and polysomal abundance in early 3T3-L1 adipogenesis. BMC Genomics, 2014, 18;15:381. [Abstract]
  34. Kramer F, Bayerlova M, Beißbarth T. (2014) R-based software for the integration of pathway data into bioinformatic algorithms. Biology (Basel), 3(1):85-100, Review. [Abstract]
  35. Fokas E, Liersch T, Fietkau R, Hohenberger W, Beißbarth T, Hess C, Becker H, Ghadimi M, Mrak K, Merkel S, Raab HR, Sauer R, Wittekind C, Rödel C. (2014) Tumor regression grading after preoperative chemoradiotherapy for locally advanced rectal carcinoma revisited: Updated results of the CAO/ARO/AIO-94 trial after a median follow-up of 11 years. Journal of Clinical Oncology, 2014, 32(15):1554-62. [Abstract]
  36. Jung K, Dihazi H, Bibi A, Dihazi GH, Beißbarth T. (2014) Adaption of the global test idea to proteomics data with missing values. Bioinformatics, 2014, 30(10):1424-30. [Abstract]
  37. Chenot JF, Hua TD, Abu Abed M, Schneider-Rudt H, Friede T, Schneider S, Vormfelde SV (2014) Safety relevant knowledge of orally anticoagulated patients: a baseline survey in primary care. BMC Family Health: 15:104. [Open Access]
  38. Patel S, Ngunjiri A, Sandhu H, Griffiths F, Thistlethwaite J, Brown S, Friede T, Lord J, Colin Tysall C, Woolvine M, Underwood M (2014) The design and development of a decision support package for low back pain. Arthritis Care & Research 66: 925-933. [Open Access]
  39. Golkowski D, Friede T, Kieser M (2014) Blinded sample size re-estimation in crossover bioequivalence trials. Pharmaceutical Statistics 13: 157–162.
  40. Pauly M, Brunner E, Konietschke F (2014) Asymptotic permutation tests in general factorial designs Royal Statistical Society, DOI: 10.1111/rssb.12073. [Abstract]
  41. K Müller, S Koster, J Painer, A Söderberg, D Gavier-Widèn, E Brunner, M Dehnhard, K Jewgenow (2014) Testosterone production and spermatogenesis in free-ranging Eurasian lynx (Lynx lynx) throughout the year European Journal of Wildlife [Abstract]
  42. Satzger I, Meier A, Zapf A, Niebuhr M, Kapp A, Gutzmer R (2014). Is there a therapeutic benefit of complete lymph node dissection in melanoma patients with low tumor burden in the sentinel node? Melanoma Research [Epub ahead of print]. [Abstract]
  43. Stallard N, Homburg T, Parsons N, Friede T (2014) Adaptive designs for confirmatory clinical trials with subgroup selection. Journal of Biopharmaceutical Statistics 24: 168-187.
  44. Kastl L, Sauer SW, Ruppert T, Beißbarth T, Becker MS, Süss D, Krammer PH, Gülow K. (2014) TNF-α mediates mitochondrial uncoupling and enhances ROS-dependent cell migration via NF-κB activation in liver cells. FEBS Lett, 2014, 588(1):175-83. [Abstract]
  45. Mansur A, Hinz J, Hillebrecht B, Bergmann I, Popov AF, Ghadimi M, Bauer M, Beißbarth T, Mihm S. (2014) Ninety-day survival rate of patients with sepsis relates to programmed cell death 1 genetic polymorphism rs11568821. J Investig Med, 2014, 62(3):638-43. [Abstract]
  46. Kottas M., Kuss O., Zapf A. (2014). A modified Wald interval for the area under the ROC curve (AUC) in diagnostic case-control studies. BMC Medical Research Methodology, 14:26. DOI: 10.1186/1471-2288-14-26. [Abstract]
  47. Brunner E., Zapf A. (2014) Nonparametric ROC Analysis for Diagnostic Trials. Encyclopedia of Clinical Trials , Volume 2: Planning, Analysis, and Inferential Methods (N. Balakrishnan, Ed.), Wiley, pp. 471-483. [Abstract]
  48. Chenot JF, Weber P, Friede T (2014) Efficacy of Ambroxol lozenges for sore throat: a meta-analysis. BMC Family Practice 15:45. DOI: 10.1186/1471-2296-15-45. [Open Access]
  49. Huppke B, Ellenberger D, Rosewich H, Friede T, Gärtner J, Huppke P (2014) Clinical presentation of pediatric multiple sclerosis before puberty. European Journal of Neurology 2: 441-446. [Abstract]
  50. Dugas M, Jöckel KH, Gefeller O, Knaup-Gregori P, Friede T, Ammenwerth E, Kieser M, Prokosch HU (2014) Freier Zugang zu Dokumentationsformularen und Merkmalskatalogen im Gesundheitswesen. Memorandum „Open Metadata“. GMS Med Inform Biom Epidemiol. 10(1):Doc01. [Open Access]
  51. Hackmann A, Wu H, Schneider UM, Meyer K, Jung K and Krebber H (2014) Quality control of spliced mRNAs requires the shuttling SR proteins Gbp2 and Hrb1. Nature Communications, 5: 3123. [Abstract]
  52. Sudau F, Friede T, Grabowski J, Koschack J, Makedonski P, Himmel W (2014) Sources of Information and Behavioral Patterns in Health Online Forums: Observational Study. J Med Internet Res 6(1):e10. doi:10.2196/jmir.2875 [Open Access]


  1. Chuang HN, van Rossum D, Sieger D, Siam L, Klemm F, Bleckmann A, Bayerlová M, Farhat K, Scheffel J, Schulz M, Dehghani F, Stadelmann C, Hanisch UK, Binder C, Pukrop T. (2013) Carcinoma cells misuse the host tissue damage response to invade the brain. Glia. 2013 Aug;61(8):1331-46.
  2. Behm T, Horowski A, Schneider S, Bock HC, Mielke D, Rohde V, Stockhammer F. (2013) Concomitant and adjuvant temozolomide of newly diagnosed glioblastoma in elderly patients. Clinical Neurology and Neurosurgery 115(10), 2142-6. [Abstract]
  3. Behnes CL, Bedke J, Schneider S, Küffer S, Strauss A, Bremmer F, Ströbel P, Radzun HJ. (2013) Myoglobin expression in renal cell carcinoma is regulated by hypoxia. Experimental and Molecular Pathology, 95(3): 307-312. [Abstract]
  4. Laskawi R, Niemczewska A, Schneider S, Winterhoff J, Beutner C, Rohrbach S. (2013) Änderung von Dosis und Injektionsmuster der Botulinumtoxin-Langzeittherapie fazialer Dyskinesien/ Changes in the dosage and injection pattern in the long-term treatment of facial dyskinesis with botulinum toxin. Laryngo-Rhino-Otologie, 93(03), 186-192. [Abstract]
  5. Nagy GCs, Wunsch M, Jordan A, Lange K (2013) Antegrade Eversion Endarterectomy of the External Iliac Artery. European Journal of Vascular and Endovascular Surgery, 46(1):103-109. [Abstract]
  6. Schiekirka S, Reinhardt D, Beißbarth T, Anders S, Pukrop T, Raupach T. (2013) Estimating learning outcomes from pre- and posttest student self-assessments: a longitudinal study. Acad Med, 2013, 88(3):369-75. [Abstract]
  7. Wolff HA, Conradi LC, Beißbarth T, Leha A, Hohenberger W, Merkel S, Fietkau R, Raab HR, Tschmelitsch J, Hess CF, Becker H, Wittekind C, Sauer R, Rödel C, Liersch T; German Rectal Cancer Study Group. (2013) Gender affects acute organ toxicity during radiochemotherapy for rectal cancer: long-term results of the German CAO/ARO/AIO-94 phase III trial. Radiother Oncol, 2013, 108(1):48-54. [Abstract]
  8. Sprenger T, Rothe H, Becker H, Beissbarth T, Homayounfar K, Gauss K, Kitz J, Wolff H, Scheel AH, Ghadimi M, Rödel C, Conradi LC, Liersch T. (2013) Lymph node metastases in rectal cancer after preoperative radiochemotherapy: impact of intramesorectal distribution and residual micrometastatic involvement. Am J Surg Pathol, 2013, 37(8):1283-9. [Abstract]
  9. Fokas E, Conradi L, Weiss C, Sprenger T, Middel P, Rau T, Dellas K, Kitz J, Rödel F, Sauer R, Rüschoff J, Beißbarth T, Arnold D, Ghadimi BM, Rödel C, Liersch T. (2013) Preoperative chemoradiation therapy with capecitabine/oxaliplatin and cetuximab in rectal cancer: long-term results of a prospective phase 1/2 study. Int J Radiat Oncol Biol Phys, 2013, 87(5):992-9. [Abstract]
  10. Camps J, Pitt JJ, Emons G, Hummon AB, Case CM, Grade M, Jones TL, Nguyen QT, Ghadimi BM, Beißbarth T, Difilippantonio MJ, Caplen NJ, Ried T (2013) Genetic amplication of the NOTCH modulator LNX2 upregulates the WNT/ß-catenin pathway in colorectal cancer Cancer Res, 2013, 73(6):2003-13. [Abstract]
  11. Kramer F, Bayerlová M, Klemm F, Bleckmann A, Beißbarth T. (2013) rBiopaxParser--an R package to parse, modify and visualize BioPAX data. Bioinformatics, 2013, 29(4):520-2. [Abstract]
  12. Brunner, E. and Puri, M.L. (2013). Comments on the paper ‘Type I error and test power of different tests for testing interaction effects in factorial experiments’ by M. Mendes and S. Yigit (Statistica Neerlandica, 2013, pp. 1–26). Statistica Neerlandica (2013) doi:10.1111/stan.12012.
  13. Brunner, E. and Puri, M.L. (2013). Letter to the Editor. WIREs Comput Stat. doi: 10.1002/wics.1280
  14. Balcarek P, Terwey A, Jung K, Wald T A, Frosch S, Schüttrunpf J P, Wachowski M M, Dathe H and Stürmer K M (2013) Influence of tibial slope asymmetry on femoral rotation in patients with lateral patellar instability. Knee Surgery, Sports Traumatology, Athroscopy, 9, 2155-2163. [Abstract]
  15. Psychogios M.K., Schramm P., Frölich A.M., Kallenberg K., Wasser K., Reinhardt L., Kreusch A., Jung K. and Knauth M. (2013): Alberta Stroke Program Early CT Scale Evaluation of Multimodal Computed Tomography in Predicting Clinical Outcomes of Stroke Patients Treated With Aspiration Thrombectomy. Stroke, 44, 2188-2193. [Abstract]
  16. Braulke F., Jung K., Schanz J., Götze K., Müller-Thomas C., Platzbecker U., Germing U., Brümmendorf T.H., Bug G., Ottmann O., Giagounidis A.A.N., Stadler M., Hofmann W.-K., Schafhausen P., Lübbert M., Schlenk R.F., Blau I.W., Ganster C., Pfeiffer S., Shirneshan K., Metz M., Detken S., Seraphin J., Jentsch-Ullrich K., Böhme A., Schmidt B., Trümper L. and Haase D. (2013) Molecular cytogenetic monitoring from CD34+ peripheral blood cells in myelodysplastic syndromes - First results from a prospective multicenter German diagnostic study. Leukemia Research, 37, 900-906. [Abstract]
  17. Kruss S, Erpenbeck L, Amschler K, Mundinger TA, Böhm H, Helms HJ, Friede T, Andrews RK, Schön MP, Spatz JP (2013) Adhesion Maturation of neutrophils on nanoscopically presented platelet glycoprotein Ibα. ACS Nano 7: 9984-9996. [Abstract]
  18. Schneider S, Schmidli H, Friede T (2013) Blinded sample size reestimation for recurrent event data with time trends. Statistics in Medicine 32: 5448–5457. [Abstract] .
  19. Mollenhauer B, Trautmann E, Sixel-Döring F, Wicke T, Ebentheuer J, Schaumburg M, Lang E, Focke NK, Kumar K, Lohmann K, Klein C, Schlossmacher M, Kohnen R, Friede T, Trenkwalder C (2013) Non-motor and diagnostic findings in de novo Parkinson’s disease subjects of the DeNoPa cohort. Neurology 81:1226–1234. [Abstract] .
  20. Steinvorth SM, Röver C, Schneider S, Nicholas R, Straube S, Friede T (2013) Explaining temporal trends in annualized relapse rates in placebo groups of randomized controlled trials in relapsing multiple sclerosis: Systematic review and meta-regression. Multiple Sclerosis Journal 19: 1580-1586. [Abstract] .
  21. Wenzel D, Zapf A. Difference of two dependent sensitivities and specificities: comparison of various approaches. Biom. J., 2013 Sep;55(5):705-18. doi: 10.1002/bimj.201200186. [Abstract]
  22. Andruszkow H, Scharff B, Zapf A, Klein M, Lerchler P, Hildebrand F, Frink M (2013). Influence of comorbidities and delay in surgical treatment on mortality following femoral neck fracture. Z Orthop Unfall, 2013 Aug;151(4):338-42. doi: 10.1055/s-0032-1328665. [Abstract]
  23. Körner S, Hendricks M, Kollewe K, Zapf A, Dengler R, Silani V, Petri S. (2013) Weight loss, dysphagia and supplement intake in patients with amyotrophic lateral sclerosis (ALS): impact on quality of life and therapeutic options BMC Neurol. 2013 Jul 12;13:84. doi: 10.1186/1471-2377-13-84. [Abstract]
  24. Moll MA, Seuthe M, von See C, Zapf A, Hornecker E, Mausberg RF, Ziebolz D. (2013) Comparison of clinical and dental panoramic findings: a practice-based crossover study BMC Oral Health. 2013 Sep 26;13(1):48. [Epub ahead of print] [Abstract]
  25. Fuchs M, Beißbarth T, Wingender E and Jung K (2013) Connecting high-dimensional mRNA and miRNA expression data for binary medical classification problems. Computer Methods and Programs in Biomedicine 111, 592-601. [Abstract]
  26. Leha A, Jung K and Beißbarth T (2013) Utilization of ordinal response structures in classification with high-dimensional expression data. Proceedings of the German Conference on Bioinformatics 2013, 90-100. [Abstract]
  27. Schneider S, Schmidli H, Friede T (2013) Robustness of methods for blinded sample size reestimation with overdispersed count data. Statistics in Medicine 32: 3623–3635. [Abstract]
  28. Koziolek MJ, Mühlhausen J, Friede T, Ellenberger D, Sigler M, Gärtner J, Müller GA, Huppke P (2013) Therapeutic apheresis in pediatric patients with acute CNS inflammatory demyelinating disease. Blood Purification 36: 92–97. [Abstract]
  29. Salendo J, Spitzner M, Kramer F, Zhang X, Jo P, Wolff HA, Kitz J, Kaulfuß S, Beißbarth T, Dobbelstein M, Ghadimi M, Grade M, Gaedcke J. (2013) Identification of a microRNA expression signature for chemoradiosensitivity of colorectal cancer cells, involving miRNAs-320a, -224, -132 and let7g. Radiother Oncol. 2013 Aug 7. doi:pii: S0167-8140(13)00311-3. 10.1016/j.radonc.2013.06.032. [Epub ahead of print] [Abstract]
  30. Spitzner M, Roesler B, Bielfeld C, Emons G, Gaedcke J, Wolff HA, Rave-Fränk M, Kramer F, Beissbarth T, Kitz J, Wienands J, Ghadimi BM, Ebner R, Ried T, Grade M. (2013) STAT3 inhibition sensitizes colorectal cancer to chemoradiotherapy in vitro and in vivo. Int J Cancer. 2013 Aug 12. doi: 10.1002/ijc.28429. [Epub ahead of print] [Abstract]
  31. Körner S, Siniawski M, Kollewe K, Rath KJ, Krampfl K, Zapf A, Dengler R, Petri S (2013). Speech therapy and communication device: Impact on quality of life and mood in patients with amyotrophic lateral sclerosis. Amyotroph Lateral Scler,14(1):20-5. [Abstract]
  32. Pape L, Ahlenstiel T, Werner CD, Zapf A (2013). Development and validation of a new statistical model for prognosis of long-term graft function after pediatric kidney transplantation. Pediatr Nephrol, 28(3):499-505. [Abstract]
  33. Goldschmidt I, Streckenbach C, Dingemann C, Pfister ED, di nanni A, Zapf A, Baumann U (2013). Application and limitations of transient liver elastography in children. J Pediatr Gastroenterol Nutr, 57(1):109-113. [Abstract]
  34. Konietschke, F., Bösiger, S., Brunner, E., Hothorn, L.A. (2013). Are Multiple Contrast Tests Superior to the ANOVA? The International Journal of Biostatistics 9, 1- 11. [Abstract].
  35. Kombrink K, Munk A, Friede T (2013) Design and semiparametric analysis of non-inferiority trials with active and placebo control for censored time to event data. Statistics in Medicine 32: 3055-3066. [Abstract].
  36. Russo SG, Stradtmann C, Crozier TA, Ringer C, Helms HJ, Quintel M, Wiese CH. (2013) Bag-mask ventilation and direct laryngoscopy versus intubating laryngeal mask airway: a manikin study of hands-on times during cardiopulmonary resuscitation. [Abstract]
  37. Michael Knösel, Amely Eckstein, Hans-Joachim Helms (2013) Durability of esthetic improvement following infiltration (ICON) of multibracket-induced white-spot lesions compared to no therapy over six months - a single-center split-mouth randomized clinical trial. [Abstract]
  38. Beyer F., Hertel D., Jung K., Fender A.C. and Leuschner C. (2013) Competition effects on fine root survival of Fagus sylvatica and Fraxinus excelsior. Forest Ecology and Management, 302, 14-22. [Abstract]
  39. Friede T, Kieser M (2013) Blinded sample size re-estimation in superiority and non-inferiority trials: Bias versus variance in variance estimation. Pharmaceutical Statistics 12: 141–146. [Abstract]
  40. Patel S, Friede T, Froud R, Evans DW, Underwood M (2013) Systematic review of randomised controlled trials of clinical prediction rules for physical therapy in low back pain. Spine 38: 762–769. [Abstract].
  41. Kieser M, Friede T, Gondan M (2013) Assessment of statistical significance and clinical relevance. Statistics in Medicine 32: 1707–1719. [Abstract]
  42. Conradi LC, Styczen H, Sprenger T, Wolff HA, Rödel C, Nietert M, Homayounfar K, Gaedcke J, Kitz J, Talaulicar R, Becker H, Ghadimi M, Middel P, Beißbarth T, Rüschoff J, Liersch T. (2013) Frequency of HER-2 Positivity in Rectal Cancer and Prognosis. Am J Surg Pathol, Issue: Volume 37(4), April 2013, p 522-531. [Abstract]
  43. Rinke S, Lange K, Ziebolz D. (2013) Retrospective Study of Extensive Heat-Pressed Ceramic Veneers after 36 Month. Journal of Esthetic and Restorative Dentistry, 25(1):42-52. [Abstract]
  44. Rinke S, Schäfer S, Lange K, Gersdorff N, Roediger M. (2013) Practice-based clinical evaluation of metal-ceramic and zirconia molar crowns: 3 year result. Journal of Oral Rehabilitation, 40(3):228-37 [Abstract]
  45. Taggart F, Friede T, Weich, Clarke A, Johnson MR, Stewart-Brown SL.(2013) Cross cultural evaluation of the Warwick-Edinburgh Mental Well-Being Scale (WEMWBS). A mixed methods study. Health and Quality of Life Outcomes 11: 27. [Open Access]
  46. Lange K, Brunner E (2013) Analysis of Predictive Values Based on Individual Risk Factors in Multi-Modality Trials. Diagnostics, 3(1), 192-209 [Open Access]
  47. Kretschmer L, Sahlmann CO, Bardzik P, Mitteldorf C, Helms HJ, Meller J, Schön MP, Bertsch HP. (2013) Individualized Surgery: Gamma-Probe-Guided Lymphadenectomy in Patients with Clinically Enlarged Lymph Node Metastases from Melanomas [Abstract]
  48. M.H.J. Heeg, G.A. Mueller, C. Bramlage, K. Homayounfar, J. Muehlhausen, A. Leha, M.J. Koziolek (2013) Improvement of Renal Graft Function After Conversion From a Calcineurin Inhibitor Including Immunosuppression to a Mycophenolate Sodium Including Regimen: A 4-year Follow-up Transplantation proceedings 1 January 2013 (volume 45 issue 1 Pages 142-147 DOI: 10.1016/j.transproceed.2012.10.028) [Abstract].
  49. Tirilomis T, Zwiehoff JM, Waldmann-Beushausen R, Schneider S, Schoendube FA. (2013) The Effect of Cardiopulmonary Bypass and Hypothermic Circulatory Arrest on Hepatic Histology in Newborn Animals: An Experimental Stud. Artificial Organs 2013; 37:E35-E39. [Abstract]
  50. Sprenger T, Conradi LC, Beißbarth T, Ermert H, Homayounfar K, Middel P, Rüschoff J, Wolff HA, Schüler P, Ghadimi BM, Rödel C, Becker H, Rödel F, Liersch T. (2013) Enrichment of CD133-expressing cells in rectal cancers treated with preoperative radiochemotherapy is an independent marker for metastasis and survival. Cancer, 2013, 119(1):26-35. [Abstract]
  51. Schneider S, Schmidli H, Friede T (2013) Blinded and unblinded internal pilot study designs for clinical trials with count data. Biometrical Journal 55: 617-633. [Abstract].


  1. Nikolin, V.M., Osterrieder, K., von Messling, V., Hofer, H., Anderson,D., Dubovi, E., Brunner, E., and L. East, M. (2012). Antagonistic Pleiotropy and Fitness Trade-offs Reveal Specialist and Generalist Traits in Strains of Canine Distemper Virus. PLoSONE Published: December 11, 2012, DOI: 10.1371/journal.pone.0050955. [Abstract].
  2. Rödig, T., Hausdörfer, T., Konietschke, F. , Dullin, C., Hahn, W., Hülsmann, M. (2012). Efficacy of D-RaCe and ProTaper Universal Retreatment NiTi-instruments in removing gutta-percha from curved root canals - a micro-computed tomography study. International Endodontic Journal, 45(6), 580-9. [Abstract].
  3. M. Knösel, W. Engelke, H.-J. Helms, A. Bleckmann (2012) An appraisal of the current and potential value of Web 2.0 contributions to continuing education in oral implantology European Journal of Dental Education, 16(3), 131-7. [Abstract].
  4. Stockhammer F, Misch M, Helms HJ, Lengler U, Prall F, von Deimling A, Hartmann C (2012) IDH1/2 mutations in WHO grade II astrocytomas associated with localization and seizure as the initial symptom Seizure, 21(3), 194-197. [Abstract].
  5. Hartmann, J., Braulke, F., Sinzig, U., Wulf, G., Maas, J. H., Konietschke, F., Haase, D. (2012). Iron overlaod influences the hematological stem cell function in patients with myelodysplastic syndromes. Leukemia Research, 37(3), 327—332. [Abstract].
  6. Bleckmann A, Siam L, Klemm F, Rietkötter E, Wegner C, Kramer F, Beißbarth T, Binder C, Stadelmann C, Pukrop T. (2012) Nuclear LEF1/TCF4 correlate with poor prognosis but not with nuclear beta-Catenin in cerebral metastasis of lung adenocarcinomas. Clin Exp Metastasis, 2012, 30(4):471-82. [Abstract]
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  8. Temme J, Kramer A, Jager KJ, Lange K, Peters F, Müller GA, Kramar R, Heaf JG, Finne P, Palsson R, Reisæter AV, Hoitsma AJ, Metcalfe W, Postorino M, Zurriaga O, Santos JP, Ravani P, Jarraya F, Verrina E, Dekker FW, Gross O. (2012) Outcomes of male patients with Alport syndrome undergoing renal replacement therapy. Clinical Journal of the American Society of Nephrology. 7(12):1969-76. [Abstract].
  9. Rinke S, Gersdorff N, Lange K, Roediger M. (2012) Prospective Evaluation of Zirconia Posterior Fixed Partial Dentures: 7-Year Clinical Results. International Journal of Prosthodontics and Restorative Dentistry, 26(2):164-71 [Abstract].
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  11. Knösel M, Forslund L, Jung K and Ziebolz D (2012) Efficacy of different strategies in protecting enamel against demineralization during fixed orthodontic treatment. Journal of Orofacial Orthopedics, 73, 194-203. [Abstract].
  12. Roessler M, Schmid D S, Michels P, Schmid O, Jung K, Stoeber J, Neumann P, Quintel M and Moerer O (2012) Early out-of-hospital non-invasive ventilation is superior to standard medical treatment in patients with acute respiratory failure: a pilot study. Emergency Medicine Journal, 29, 409-414. [Abstract]
  13. Hennies S., Wolff H.A., Jung K., Rave-Fränk M., Gaedcke J., Ghadimi M., Hess C.F., Becker H., Hermann R.H. and Christiansen H. (2012) Influence of testicular radiation dose on hormone levels, quality of life and sexual functioning in patients treated with multimodal curative therapy (neoadjuvant radiochemotherapy, surgery, and adjuvant chemotherapy) for locally advanced rectal cancer. Strahlentherapie und Onkologie, 188, 926-932. [Abstract]
  14. Xyda A., Haberland U., Klotz E., Jung K., Bock H.C., Schramm R., Knauth M. and Schramm P. (2012) Diagnostic performance of whole brain volume perfusion CT in intra-axial brain tumors: Preoperative classification accuracy and histopathologic correlation. European Journal of Radiology, 81, 4105-4111. [Abstract]
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  23. Raupach T, Schiekirka S, Münscher C, Beißbarth T, Himmel W, Burckhardt G, Pukrop T. (2012) Piloting an outcome-based programme evaluation tool in undergraduate medical education. GMS Z Med Ausbild, 2012, 29(3):Doc44. [Abstract]
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  41. Artmann S, Jung K, Bleckmann A, Beißbarth T. (2012) Detection of simultaneous Group Effects in microRNA Expression and related Target Gene Sets. PLoS ONE, 2012, e38365. [Abstract].
  42. Nicholas R, Straube S, Schmidli H, Pfeiffer S, Friede T (2012) Time-patterns of annualized relapse rates in randomized placebo-controlled clinical trials in relapsing multiple sclerosis: A systematic review and meta-analysis. Multiple Sclerosis Journal 18: 1290-1296. [Abstract]
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  45. Konietschke, F., Pauly, M. (2012). A studentized permutation test for the nonparametric Behrens-Fisher problem in paired data. The Electronic Journal of Statistics 6, 1358--1372. [Abstract]
  46. Gross O, Friede T, Hilgers R, Görlitz A, Gavenis K, Ahmed R, Dürr U (2012) Safety and efficacy of the ACE-inhibitor ramipril in Alport syndrome: The double-blind, randomized, placebo-controlled, multicenter phase III EARLY PRO-TECT Alport trial in pediatric patients. ISRN Pediatrics Volume 2012, Article ID 436046, 6 pages, doi:10.5402/2012/436046. [Abstract].
  47. Friede T, Miller F (2012) Blinded continuous monitoring of nuisance parameters in clinical trials. Journal of the Royal Statistical Society Series C 61: 601–618. [Abstract].
  48. Lange K, Bähr M, Hein K.(2012) Author response: retinal nerve fiber layer thickness measurements in rats with the spectral domain optical coherence tomography. Investigative Ophthalmology & Visual Science, 53(7): 3570-3571. [Abstract].
  49. Temme J, Peters F, Lange K, Pirson Y, Heidet L, Torra R, Grunfeld JP, Weber M, Licht C, Müller GA, Gross O. (2012) Incidence of renal failure and nephroprotection by RAAS inhibition in heterozygous carriers of X-chromosomal and autosomal recessive Alport mutations. Kidney international 81: 779-783. [Abstract].
  50. Hein K, Gadjanski I, Kretzschmar B, Lange K, Diem R, Sättler MB, Bähr M. (2012) An optical coherence tomography study on degeneration of retinal nerve fiber layer in rats with autoimmune optic neuritis. Investigative Ophthalmology & Visual Science, 53(1):157-163. [Abstract].
  51. Gross O , Licht C, Anders HJ, Hoppe B, Beck B, Tönshoff B, Höcker B, Wygoda S, Ehrich JHH, Pape L, Konrad M, Rascher W, Dötsch J, Müller-Wiefel DE, Hoyer P, and Study Group Members of the Gesellschaft für Pädiatrische Nephrologie (GPN), Knebelmann B, Pirson Y, Grunfeld JP, Niaudet P, Cochat P, Heidet L, Torra R, Friede T, Lange K, Müller GA, Weber M. (2012). Early angiotensin-converting enzyme inhibition in Alport syndrome delays renal failure and improves life expectancy. Kidney International 81(5): 494-501. [Abstract].
  52. Konietschke, F. , Harrar, S.W., Lange, K., Brunner, E. (2012). Ranking procedures for matched pairs with missing values - Asymptotic theory and a small sample approximation. Computational Statistics & Data Analysis, 56 (5): 1090-1102. [Abstract].
  53. A. Ali, N Christensen, R. Meyer, C. Röver (2012) Bayesian inference on EMRI signals using low frequency approximations. Classical and Quantum Gravity, 29(14):145014. [Abstract]
  54. Homayounfar K, Bleckmann A, Conradi LC, Sprenger T, Beißbarth T, Lorf T, Niessner M, Sahlmann CO, Meller J, Becker H, Liersch T, Ghadimi BM. (2012) Bilobar spreading of colorectal liver metastases does not significantly affect survival after R0 resection in the era of interdisciplinary multimodal treatment. Int J Colorectal Dis, 2012, epub DOI: 10.1007/s00384-012-1455-1. [Abstract]
  55. Strobel L, Schneider NK, Krampe H, Beißbarth T, Pukrop T, Anders S, West R, Aveyard P, Raupach T. (2012) German medical students lack knowledge of how to treat smoking and problem drinking. Addiction, 2012, epub. DOI: 10.1111/j.1360-0443.2012.03907.x [Abstract]
  56. Karpiuk O, Najafova Z, Kramer F, Hennion M, Galonska C, König A, Snaidero N, Vogel T, Shchebet A, Begus-Nahrmann Y, Kassem M, Simons M, Shcherbata H, Beißbarth T, Johnsen SA. (2012) The Histone H2B Monoubiquitination Regulatory Pathway Is Required for Differentiation of Multipotent Stem Cells. Mol Cell, 2012, 46(5):705-13. [Abstract]
  57. Sauer R, Liersch T, Merkel S, Villanueva MT, Fietkau R, Hohenberger W, Hess C, Becker H, Raab HR, Witzigmann H, Wittekind C, Beißbarth T, Rödel C.(2012) Preoperative versus postoperative chemoradiotherapy for locally advanced rectal cancer: Results of the German CAO/ARO/AIO-94 randomized phase III trial after a median follow up of 11 years. Journal of Clinical Oncology, 2012, 30(16):1926-33. [Abstract]
  58. Schirmer MA, Nadine Mergler CP, Rave-Fränk M, Herrmann MK, Hennies S, Gaedcke J, Conradi LC, Jo P, Beißbarth T, Hess CF, Becker H, Ghadimi M, Brockmöller J, Christiansen H, Wolff HA. (2012) Acute Toxicity of Radiochemotherapy in Rectal Cancer Patients: A Risk Particularly for Carriers of the TGFB1 Pro25 variant. Int J Radiat Oncol Biol Phys, 83(1):149-57 [Abstract]
  59. Gerlinger C, Edler L, Friede T, Kieser M, Nakas CT, Schumacher M, Seldrup J, Victor N (2012) Considerations on what constitutes a ”Qualified Statistician” in regulatory guidelines. Statistics in Medicine 31: 1303–1305. [Abstract]
  60. von der Heyde S, Beißbarth T (2012) A new analysis approach of epidermal growth factor receptor pathway activation patterns provides insights into cetuximab resistance mechanisms in head and neck cancer. BMC Medicine 2012, 10 (1):43 [Abstract]
  61. Fromm-Dornieden C, von der Heyde S, Lytovchenko O, Salinas-Riester G, Brenig B, Beißbarth T, Baumgartner BG (2012) Novel polysome messages and changes in translational activity appear after induction of adipogenesis in 3T3-L1 cells. BMC Molecular Biology, 2012, 13:9 [Abstract]
  62. Homayounfar K., Meis J., Jung K., Klosterhalfen B., Sprenger T., Conradi L.C., Langer C. and Becker H. (2012) Ultrasonic scalpel causes greater depth of soft tissue necrosis compared to monopolar electrocautery at standard power level settings in a pig model. BMC Surgery, 12:3. [Abstract]
  63. Lee D-H, Geyer E, Flach A-C, Jung K, Gold R, Flügel A, Linker R A, Lühder F (2012) Central nervous system rather than immune cell-derived BDNF mediates axonal protective effects early in autoimmune demyelination. Acta Neuropathologica, 123, 247-258. [Abstract]
  64. Alt-Epping B, Nejad R K, Jung K, Groß U and Nauck F (2012) Symptoms of the oral cavity and their associations with local microbiological and clinical findings – a prospective survey in palliative care. Support Care Cancer, 20, 531-537. [Abstract]
  65. Jo P, Jung K, Grade M, Conradi LC, Wolff HA, Kitz J, Rüschoff J, Hartmann A, Becker H, Beißbarth T, Müller A, Ghadimi MB, Schneider-Stock R, Gaedcke R. (2012) CpG island methylator phenotype infers a poor prognosis in locally advanced rectal cancer.Surgery, 151, 564-570.[Abstract]
  66. Pratsch AL, Schneider S, Kretschmer L (2012) Schwellungsempfinden, klinische Schwellungszeichen und manifestes Lymphödem –Schwierigkeiten bei der Quantifizierung von Beinschwellungen. Phlebologie 2012. 41 1: 5-11. [Abstract].
  67. Seegers J, Vos MA, Willems R, Flevari P, Dorenkamp M, Sohns C, Vollmann D, Lüthje L, Kremastinos DT, Floré V, Meine M, Tuinenburg A, Connelly DT, Myles RC, Marshall GE, Simon D, Brockmöller J, Friede T, Hasenfuß G, Lehnart SE, Zabel M for the EUTrigTreat Clinical Study Investigators (2012) Rationale, objectives and design of the EUTrigTreat Clinical Study: A prospective observational study for arrhythmia risk stratification and assessment of interrelationships among repolarisation markers and genotype. EP-Europace 14: 416–422. [Abstract].
  68. Lange K, Brunner E (2012). Sensitivity, specificity and ROC-curves in ultiple reader diagnostic trials — A unified, nonparametric approach. Statistical Methodology. [Abstract].
  69. Parsons N, Friede T, Todd S, Valdés-Márquez E, Chataway J, Nicholas R, Stallard N (2012) An R package for implementing simulations for seamless phase II/III clinical trials using early outcomes for treatment selection. Computational Statistics and Data Analysis 56: 1150-1160. [Abstract].
  70. Heuer JF, Sauter P, Pelosi P, Herrmann P, Brück W, Perske C, Schoendube F, Crozier TA, Bleckmann A, Beißbarth T, Quintel M (2012) Effects of Pulmonary Acid Aspiration on the lungs and extra-pulmonary organs: A randomized study in pigs. Critical Care, 2012, 16(2):R35. [Abstract].
  71. Hummon AB, Pitt JJ, Camps J, Emons G, Skube SB, Huppi K, Jones TL, Beißbarth T, Kramer F, Grade M, Difilippantonio MJ, Ried T, Caplen NJ (2012) Systems-wide RNAi analysis of CASP8AP2/FLASH shows transcriptional deregulation of the replication-dependent histone genes and extensive effects on the transcriptome of colorectal cancer cells Mol Cancer. 2012 Jan 4;11(1):1 [Abstract].
  72. Raupach T, Schiekirka S, Münscher C, Beißbarth T, Himmel W, Burckhardt G, Pukrop T (2012) Implementierung und Erprobung eines Outcome-orientierten Evaluationssystems im Studium der Humanmedizin. GMS Zeitschrift für Medizinische Ausbildung, 2012, 229 (3):Doc44. [Abstract]


  1. Kendziorra E, Ahlborn K, Spitzner M, Rave-Fränk M, Emons G, Gaedcke J, Kramer F, Wolff HA, Becker H, Beißbarth T, Ebner R, Ghadimi BM, Pukrop T, Ried T, Grade M. (2011) Silencing of the Wnt transcription factor TCF4 sensitizes colorectal cancer cells to (chemo-) radiotherapy. Carcinogenesis. 2011, 32(12):1824-31. [Abstract].
  2. Ziebolz D, Pabel SO, Lange K, Krohn-Grimberghe B, Hornecker E, Mausberg RF. (2011) Clinical Periodontal and Microbiologic Parameters in Patients with Rheumatoid Arthritis. J Periodontology, 82(10):1424-1432. [Abstract]
  3. Hahn W, Wasser-Merkel W, Lange K, Gruber RM, Kubein-Meesenburg D ; Ihlow, D. (2011). Accuracy of fit of 3-to-3 retainers after adhesive fixation using a neodymium–iron–boron magnet chain. Journal of Orofacial Orthopedics / Fortschritte der Kieferorthopdie, 72(5): 381-388. [Abstract]
  4. Konietschke, F., Hothorn, L.A., Brunner, E. (2011). Rank-based multiple test procedures and simultaneous confidence intervals. The Electronic Journal of Statistics 6, 737-758. [Abstract]
  5. Gross O , Licht C, Anders HJ, Hoppe B, Beck B, Tönshoff B, Höcker B, Wygoda S, Ehrich JHH, Pape L, Konrad M, Rascher W, Dötsch J, Müller-Wiefel DE, Hoyer P, and Study Group Members of the Gesellschaft für Pädiatrische Nephrologie (GPN), Knebelmann B, Pirson Y, Grunfeld JP, Niaudet P, Cochat P, Heidet L, Torra R, Friede T, Lange K, Müller GA, Weber M. (2011). Early angiotensin-converting enzyme inhibition in Alport syndrome delays renal failure and improves life expectancy. Kidney International 81: 494–501. [Abstract]
  6. Hahn W, Engelke B, Jung K, Dathe H, Kramer F-J, Rödig T, Kubein-Meesenburg D and Gruber R M (2011) The influence of occlusal forces on force delivery properties of aligners during rotation of an upper central incisor. Angle Orthdontist, in print. [Abstract]
  7. Psychogios M K, Wachter D, Mohr A, Schramm P, Frölich A-M, Jung K, Rohde V, Knauth M (2011) Feasibility of flat panel angiographic computed tomography after intravenous contrast agent application in the postoperative evaluation of patients with clipped aneurysms. American Journal of Neuroradiology, in print. [Abstract]
  8. Balcarek P, Jung K, Frosch K-H and Stürmer K M (2011) Value of the Tibial Tuberosity-Trochlear Groove Distance in Patellar Instability in the Young Athlete. American Journal of Sports Medicine, in print. [Abstract]
  9. Brase JC, Johannes M, Mannsperger H, Fälth M, Metzger J, Kacprzyk LA, Andrasiuk T, Gade S, Meister M, Sirma H, Sauter G, Simon R, Schlomm T, Beißbarth T, Korf U, Kuner R, Sültmann H (2011) TMPRSS2-ERG-specific transcriptional modulation is associated with prostate cancer biomarkers and TGF-beta signaling. BMC Cancer, 2011, 11(1):507.
  10. Gade S, Porzelius C, Fälth M, Brase JC, Wuttig D, Kuner R, Binder H, Sültmann H, Beißbarth T. (2011) Graph based fusion of miRNA and mRNA expression data improves clinical outcome prediction in prostate cancer. BMC Bioinformatics, 2011, 12(1):488.[Abstract]
  11. Schillinger W, Athanasiou T, Weicken N, Berg L, Tichelbäcker T, Puls M, Hünlich M, Wachter R, Helms HJ, Seipelt R, Schöndube FA, Hasenfuss G (2011) Impact of the learning curve on outcomes after percutaneous mitral valve repair with MitraClip and lessons learned after the first 75 consecutive patients European Journal of Heart Failure 2011 Dec;13(12):1331-9. Epub [Abstract].
  12. Thapar A, Lane T, Nicholas R, Friede T, Ellis M, Assenheim J, Franklin IJ, Davies AH (2011) Systematic review of sonographic CCSVI findings in multiple sclerosis. Phlebology 26: 319-25. [Abstract]
  13. Prenzel T, Begus-Nahrmann Y, Kramer F, Hennion M, Hsu C, Gorsler T, Hintermair C, Eick D, Kremmer E, Simons M, Beißbarth T, Johnsen SA (2011). Estrogen-Dependent Gene Transcription in Human Breast Cancer Cells Relies upon Proteasome-Dependent Monoubiquitination of Histone H2B. Cancer Res. 2011 Sep 1;71(17):5739-53. [Abstract]
  14. Danner C.B., Hellms T., Jung K., Gunawan B., Didilis V., Füzesi L. and Schöndube F.A. (2011): Prognostic values of chromosomal imbalances in squamous cell carcinoma and adenocarcinoma of the lung. Annals of Thoracic Surgery, 92, 1038-1043. [Abstract]
  15. Jung K., Goerdt C., Lange P., Blocher J., Djukic M., Gerber J., Spreer A., Nau R., Otto M., Schmidt H. (2011): The use of S100B and Tau Protein Concentrations in the Cerebrospinal Fluid for the Differential Diagnosis of Bacterial Meningitis: a Retrospective Analysis. European Neurology, 66, 128-132. [Abstract]
  16. Nicholas R, Straube S, Schmidli H, Schneider S, Friede T (2011) Trends in annualized relapse rates in relapsing remitting multiple sclerosis and consequences for clinical trial design. Multiple Sclerosis Journal 2011; 17: 1211-1217. [Abstract]
  17. Bramlage CP, Müller GA, Tampe B, Bevanda J, Maatouk I, Koziolek M, Lange K, Ahrens K, Schmid H, Cohen CD, Bramlage P, Kretzler M, Strutz F. (2011) The role of bone morphogenetic protein-5 (BMP-5) in human nephrosclerosis. Journal of Nephrology, 24(5): 647-655. [Abstract]
  18. Rinke S, Ohl S, Ziebolz D, Lange K, Eickholz P. (2011) Prevalence of periimplant disease in partially edentulous patients: a practice-based cross-sectional study. Clinical Oral Implants Research, 22: 826–833. [Abstract]
  19. Rossenbach J, Mueller GA, Lange K, Armstrong VW, Schmitto JD, Hintze E, Helfmann J, Konstantinides S, Koziolek MJ. (2011) Lipid-apheresis improves microcirculation of the upper limbs. Journal of Clinical Apheresis, 26: 167–173. [Abstract]
  20. Xyda A, Haberland U, Klotz E, Bock H C, Jung K, Knauth M, Schramm R, Psychogios M N, Erb G, Schramm P (2011). Brain volume perfusion CT performed with 128-detector row CT system in patients with cerebral gliomas: A feasibility study. European Radiology, 9, 1811-1819. [Abstract]
  21. Kretschmer L, Starz H, Thoms K-M, Satzger I, Völker B, Jung K, Mitteldorf C, Bader C, Siedlecki K, Kapp A, Bertsch H P and Gutzmer R (2011). Age as a key factor influencing metastasizing patterns and disease-specific survival after sentinel lymph node biopsy for cutaneous melanoma. International Journal of Cancer, 6, 1435-1442. [Abstract]
  22. Danner B.C., Gerdes J.S., Enders C., Jung K., Sander B., Liersch T., Seipelt R., Gutenberg A., Gunawan B., Schöndube F.A. and Füzesi L. (2011). Comparison of chromosomal aberrations in primary colorectal carcinomas to their pulmonary metastases. Cancer Genetics, 204, 122-128. [Abstract]
  23. Knösel M and Jung K (2011). Informational value and bias of videos related to orthodontics screened on a video-sharing Web site. Angle Orthodontist, 81, 532-539. [Abstract]
  24. Raupach T, Münscher C, Beißbarth T, Burckhardt G, Pukrop T (2011). Towards outcome-based programme evaluation: Using student comparative self-assessments to determine teaching effectiveness. Med Teach; 33(8):e446-e453 [Abstract]
  25. Wolff HA, Conradi LC, Schirmer M, Beißbarth T, Sprenger T, Rave-Fränk M, Hennies S, Hess CF, Becker H, Christiansen H, Liersch T. (2011) Gender-specific acute organ toxicity during intensified preoperative radiochemotherapy for rectal cancer. Oncologist, 2011, 16(5):621-31. [Abstract]
  26. Bender C, Heyde S, Henjes F, Wiemann S, Korf U, Beißbarth T. (2011) Inferring signalling networks from longitudinal data using sampling based approaches in the R-package 'ddepn'. BMC Bioinformatics 2011, 12:291. [Abstract]
  27. Jung K, Friede T, Beißbarth T (2011) Reporting FDR analogous confidence intervals for the log fold change of differentially expressed genes. BMC Bioinformatics 12:288. [Open Access PDF]
  28. Clarke A, Friede T, Putz R, Ashdown J, Martin S, Blake A, Adi Y, Parkinson J, Flynn P, Platt S, Stewart-Brown S. (2011) Warwick-Edinburgh Mental Well-being Scale (WEMWBS): Validated for teenage school students in England and Scotland. A mixed methods assessment. BMC Public Health 11: 487. [Open Access PDF]
  29. Friede T, Parsons N, Stallard N, Todd S, Valdés-Márquez E, Chataway J, Nicholas R (2011) Designing a seamless phase II/III clinical trial using early outcomes for treatment selection: An application in multiple sclerosis. Statistics in Medicine 30: 1528-1540. [Abstract]
  30. Friede T, Kieser M (2011) Reassessment of sample size in internal pilot study designs for non-inferiority trials evaluated with ANCOVA. Methods of Information in Medicine 50: 237-243. [Abstract]
  31. Nicholas R, Giannetti P, Alanousi A, Friede T, Muraro PA (2011) Development of oral immunomodulatory agents in the management of multiple sclerosis. Drug Design, Development and Therapy 5: 255–274. [Open Access PDF]
  32. Leha A, Beißbarth T, Jung K (2011) Sequential Interim Analyses of Survival Data in DNA Microarray Experiments. BMC Bioinformatics, 12(1):127. [Abstract]
  33. Jung K, Becker B, Brunner B, Beißbarth T (2011) Comparison of Global Tests for Functional Gene Sets in Two-Group Designs and Selection of Potentially Effect-causing Genes. Bioinformatics, 2011 27: 1377-1383. [Abstract]
  34. Johannes M, Fröhlich H, Sültmann H, Beißbarth T (2011) pathClass: An R-Package for Integration of Pathway Knowledge into Support Vector Machines for Biomarker Discovery. Bioinformatics, 2011, 27(10):1442-3 [Abstract]
  35. Conradi LC, Bleckmann A, Schirmer M, Sprenger T, Jo P, Homayounfar K, Wolff HA, Rothe H, Middel P, Becker H, Ghadimi MB, Beißbarth T, Liersch T. (2011) Thymidylate Synthase as a Prognostic Biomarker for Locally Advanced Rectal Cancer after multimodal Treatment. Ann Surg Oncol, 18(9):2442-52. [Abstract]
  36. Porzelius C, Johannes M, Binder H, Beißbarth T (2011) Leveraging external knowledge on molecular interactions in classification methods for risk prediction of patients. Biometrical Journal, 53(2):190-201. [Abstract]
  37. Klemm F, Bleckmann A, Siam L, Chuang HN, Rietkötter E, Behme D, Schulz M, Schaffrinski M, Schindler S, Trümper L, Kramer F, Beißbarth T, Stadelmann C, Binder C, Pukrop T (2011) b-catenin-independent WNT signaling in basal-like breast cancer and brain metastasis. Carcinogenesis, 2011, 32(3):434-42. [Abstract]
  38. Hua TD, Vormfelde SV, Abu Abed M, Schneider-Rudt H, Sobotta P, Friede T, Chenot JF (2011) Practice nursed-based, individual and video-assisted patient education in oral anticoagulation - Protocol of a cluster-randomized controlled trial. BMC Family Practice 12: 17. [Open Access PDF]
  39. Wolff H A, Daldrup B, Jung K, Overbeck T, Hennies S, Matthias C, Hess C F, Roedel R M W, Christiansen H (2011) High-grade acute organ toxicity as positive prognostic factor in adjuvant radiation and chemotherapy for locally advanced head and neck cancer. Radiology, 258, 864-871. [Abstract]
  40. Engelke W, Jung K and Knösel M (2011) Intra-oral compartment pressures: a biofunctional model and experimental measurements under different conditions of posture. Clinical Oral Investigations, 15, 165-176. [Abstract]
  41. Wolff H A, Raus I, Jung K, Schüler P, Herrmann M K, Hennies S, Vorwerk H, Hille A, Hess C F and Christiansen H (2011) High-grade Acute Organ Toxicity as a Positive Prognostic Factor in Primary Radiochemotherapy for Anal Carcinoma. International Journal of Radiation Oncology Biology Physics, 79, 1467-1478. [Abstract]
  42. Varges D, Jung K, Gawinecka J, Heinemann U, Schmitz M, von Ahsen N, Krasnianski A, Amstrong V W and Zerr I (2011) Amyloid-beta 1-42 levels are modified by Apolipoprotein E epsilon4 in Creutzfeldt-Jakob Disease in a similar manner as in Alzheimer's Disease. Journal of Alzheimer's Disease, 23, 717-726. [Abstract]
  43. Patel S, Brown S, Friede T, Griffiths F, Lord J, Thistlethwaite J, Tysall C, Woolvine M, Underwood M (2011) Study protocol: Improving patient choice in treating low back pain (IMPACT - LBP): A randomised controlled trial of a decision support package for use in physical therapy. BMC Musculoskeletal Disorders 12: 52. [Open Access PDF]
  44. Wolff H A, Hennies S, Herrmann M K A, Rave-Fränk M, Eickelmann D, Virsik P, Jung K, Schirmer M, Ghadimi B M, Hess C F, Hermann R M and Christiansen H (2011) Comparison of micronucleus- and chromosome aberration technique for the documentation of cytogenic dam-age in radiochemotherapy treated patients with rectal cancer. Strahlentherapie und Onkologie, 187, 52-58. [Abstract]
  45. Friede T, Kieser M (2011) Blinded sample size recalculation for clinical trials with Normal data and baseline adjusted analysis. Pharmaceutical Statistics 10: 8 - 13. [Abstract]
  46. Bramlage C, Cuneo A, Härtel D, Jung K, Witteck C-H, Högel R, Müller G A, Bramlage P and Tebbe U (2011) Nierenarterienstenose: Intervention oder medikamentöse Behandlung? Deutsche Medizinische Wochenschrift, 136, 76-81. [Abstract]
  47. Kieser M, Friede T (2011) Authors’ reply to Comments by G. Li on ‘Planning and analysis of three-arm non-inferiority trials with binary endpoints’. Statistics in Medicine 30: 300. [Abstract]
  48. Chataway J, Nicholas R, Todd, S, Parsons N, Todd S, Miller D, Valdés-Márquez E, Stallard N, Friede T (2011) A novel adaptive design strategy increases the efficiency of clinical trials in secondary progressive multiple sclerosis. Multiple Sclerosis 17: 81-88. [Abstract]


  1. Konietschke, F., Bathke, A. C., Hothorn, L. A., Brunner, E. (2010). Testing and Estimation of purely nonparametric effects in repeated measures designs . Computational Statistics & Data Analysis 54, 1895 - 1905. [Abstract]
  2. Rödig T, Sedghi M, Konietschke F, Lange K, Ziebolz D, Hülsmann M. (2010) Efficacy of syringe irrigation, RinsEndo and passive ultrasonic irrigation in removing debris from irregularities in root canals with different apical sizes. Int Endod J. 2010 Jul;43(7):581-9. PubMed PMID: 20636517. [Abstract]
  3. Bramlage CP, Tampe B, Koziolek M, Maatouk I, Bevanda J, Bramlage P, Ahrens K, Lange K, Schmid H, Cohen CD, Kretzler M, Müller GA. (2010) Bone Morphogenetic Protein (BMP)-7 expression is decreased in human hypertensive nephrosclerosis. BMC Nephrol. 2010 Nov 16;11:31. PubMed PMID: 21080950; PubMed Central PMCID: PMC3002344. [Abstract]
  4. Sprenger T, Rödel F, Beißbarth T, Conradi LC, Rothe H, Homayounfar K, Wolff HA, Ghadimi BM, Yildirim M, Becker H, Rödel C, Liersch T (2010) Failure of down-regulation of Survivin following neoadjuvant radiochemotherapy in rectal cancer is associated with distant metastases and shortened survival.Clinical Cancer Research, 17(6):1623-31. [Abstract]
  5. Nicholas R, Young C, Friede T (2010) Bladder symptoms in Multiple Sclerosis: a review of pathophysiology and management. Expert Opinion on Drug Safety: 905-915. [Abstract]
  6. Psychogios M-N, Schramm P, Buhk J-H, Xyda A, Gröschel K, Jung K and Knauth M (2010) Angiographic CT after Intravenous Contrast Agent Application: A Noninvasive Follow-Up Tool after Intracranial Angioplasty and Stenting. American Journal of Neuroradiology, 31, 1886-1891. [Abstract]
  7. Blanchard G, Dickhaus T, Hack N, Konietschke F, Rohmeyer K, Rosenblatt J, Scheer M & Werft W (2010) mTOSS - Multiple hypothesis testing in an open software system JMLR: Workshop and Conference Proceedings 11, 12-19. Workshop on Applications of Pattern Analysis [Abstract]
  8. Balcarek P, Jung K, Ammon J, Walde T A, Frosch S, Schüttrumpf J P, Stürmer K M and Frosch K-H (2010) Anatomy of lateral patellar instability: Trochlear dysplasia and TT-TG distance is more pronounced in females who dislocate their patella. American Journal of Sports Medicine, 38, 2320-2327. [Abstract]
  9. Knösel M, Jung K, Kinzinger G, Bauss O and Engelke W (2010) A controlled evaluation of oral screen effects on intra-oral pressure curve characteristics. European Journal of Orthodontics, 32, 535-541. [Abstract]
  10. Lüers C, Hagenah G, Wachter R, Kleta S, Schaumberg J, Riedel S, Binder L, Jung K, Schmidt A and Pieske B (2010) Bedeutung der Surfactant-Proteine B und D in der Differentialdiagnostik der akuten Dyspnoe. Medizinische Klinik, 105, 611-618. [Abstract]
  11. Braulke F, Schanz J, Jung K, Shirneshan K, Schulte K, Schuetze C, Steffens R, Trümper L and Haase D (2010) FISH analysis of circulating CD34+ cells as a new tool for genetic monitoring in MDS: Verification of the method and application to 27 MDS patients. Leukemia Research, 34, 1296-1301. [Abstract]
  12. Knösel M, Mattysek M, Jung K, Sadat-Khonsari R, Kubein-Meesenburg D, Bauss O. and Ziebolz D (2010) Impulse debracketing compared to conventional debonding. Angle Orthodontist, 80, 1036-1044. [Abstract]
  13. Schneider H, Kriebel T, Jung K, Gravenhorst V D and Paul T (2010) Catheter Ablation of Idiopathic Left and Right Ventricular Tachycardias in the Pediatric Population Using Noncontact Mapping. Heart Rhythm, 7, 731-739. [Abstract]
  14. Knösel M, Mattysek S, Jung K, Kubein-Meesenburg D, Sadat-Khonsari R and Ziebolz D (2010) Suitability of orthodontic brackets for rebonding and reworking following removal by air pressure pulses and conventional debracketing techniques. Angle Orthodontist, 80, 461-467. [Abstract]
  15. Wolff H A, Bosch J, Jung K, Overbeck T, Hennies S, Matthias C, Hess C F, Roedel R M and Christiansen H. (2010) High-grade acute organ toxicity as positive prognostic factor in primary radio(chemo)therapy for locally advanced, inoperable head and neck cancer. Strahlentherapie und Onkologie, 186, 262-268. [Abstract]
  16. Sprenger T, Rothe H, Jung K, Christiansen H, Conradi L C, Ghadimi B M, Becker H and Liersch T (2010) Stage II/III rectal cancer with intermediate response to preoperative radiochemotherapy: Do we have indications for individual risk stratification? World Journal of Surgical Oncology, 8:27. [Abstract]
  17. Gutenberg A, Gerdes J S, Jung K, Sander B, Gunawan B, Bock H C, Liersch T, Brück W, Rhode V and Füzesi L (2010) High chromosomal instability in brain metastases of colorectal carcinoma. Cancer Genetics and Cytogenetics, 198, 47-51. [Abstract]
  18. Benda N, Brannath W, Bretz F, Burger HU, Friede T, Maurer W, Wang SJ (2010) Perspectives on the use of adaptive designs in clinical trials: Part II Panel Discussions. Journal of Biopharmaceutical Statistics 20: 1098 – 1112. [Abstract]
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  9. Kociszewski J, Rautenberg O, Perucchini D, Eberhard J, Geissbühler V, Hilgers R, Viereck V (2008) Tape functionality: sonographic tape characteristics and outcome after TVT incontinence surgery. NEUROUROL URODYNAM, 27(6): 485-90.
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  11. Lippert U, Zachmann K, Ferrari DM, Schwarz H, Brunner E, Latif AH, Neumann C, Soruri A (2008) Correction: CD137 ligand reverse signaling has multiple functions in human dendritic cells during an adaptive immune response. EUR J IMMUNOL, 38(6): 1767.
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  1. Brockmann K, Becker P, Schreiber G, Neubert K, Brunner E, Bönnemann C (2007) Sensitivity and specificity of qualitative muscle ultrasound in assessment of suspected neuromuscular disease in childhood. NEUROMUSCULAR DISORD, 17(7): 517-23.
  2. Eich C, Bräuer A, Timmermann A, Schwarz SK, Russo SG, Neubert K, Graf BM, Aleksic I (2007) Outcome of 12 drowned children with attempted resuscitation on cardiopulmonary bypass: an analysis of variables based on the "Utstein Style for Drowning". RESUSCITATION, 75(1): 42-52.
  3. Elsner L, Muppala V, Gehrmann M, Lozano J, Malzahn D, Bickeböller H, Brunner E, Zientkowska M, Herrmann T, Walter L, Alves F, Multhoff G, Dressel R (2007) The heat shock protein HSP70 promotes mouse NK cell activity against tumors that express inducible NKG2D ligands. J IMMUNOL, 179(8): 5523-33.
  4. Happe S, Bachmann CG, Helmschmied K, Neubert K, Wuttke W, Paulus W, Trenkwalder C (2007) Growth hormone response to low-dose apomorphine in restless legs syndrome. GROWTH HORM IGF RES, 17(4): 323-7.
  5. Harms L, Emons G, Bader W, Lange R, Hilgers R, Viereck V (2007) Funneling before and after anti-incontinence surgery--a prognostic indicator? Part 2: tension-free vaginal tape. INT UROGYNECOL J, 18(3): 289-94.
  6. Heutelbeck AR, Janicke N, Hilgers R, Kütting B, Drexler H, Hallier E, Bickeböller H (2007) German cattle allergy study (CAS): public health relevance of cattle-allergic farmers. INT ARCH OCC ENV HEA, 81(2): 201-8.
  7. Koziolek MJ, Schmid H, Cohen CD, Blaschke S, Hemmerlein B, Zapf A, Müller GA, Strutz F (2007) Potential role of fractalkine receptor expression in human renal fibrogenesis. KIDNEY INT, 72(5): 599-607.
  8. Lehmann GB, Asskali F, Boll M, Burmeister MA, Marx G, Hilgers R, Förster H (2007) HES 130/0.42 shows less alteration of pharmacokinetics than HES 200/0.5 when dosed repeatedly. BRIT J ANAESTH, 98(5): 635-44.
  9. Lennon AM, Wiegand A, Buchalla W, Wahl B, Werner C, Betke H, Hannig C, Rödig T, Attin T (2007) Subjectivity and examiner experience in diagnosis of residual caries--an in vitro study. Schweiz Monatsschr Zahnmed, 117(2): 123-7.
  10. Mirzaie M, Brunner E, Mahbub-ul Latif AH, Schmitto J, Fatehpur S, Schöndube F (2007) A new storage solution for porcine aortic valves. Ann Thorac Cardiovasc Surg, 13(2): 102-9.
  11. Neubert K, Brunner E (2007) A studentized permutation test for the non-parametric Behrens-Fisher problem. COMPUT STAT DATA AN, 51(10): 5192-5204.
  12. Schillinger W, Teucher N, Sossalla S, Kettlewell S, Werner C, Raddatz D, Elgner A, Tenderich G, Pieske B, Ramadori G, Schöndube FA, Kögler H, Kockskämper J, Maier LS, Schwörer H, Smith GL, Hasenfuss G (2007) Negative inotropy of the gastric proton pump inhibitor pantoprazole in myocardium from humans and rabbits: evaluation of mechanisms. CIRCULATION, 116(1): 57-66.
  13. Thangavelu K, Brunner E (2007) Wilcoxon-Mann-Whitney Test for Stratified Samples and Efron's Paradox Dice. J STAT PLAN INFER, 137(3): 720-37.
  14. von Lewinski F, Werner C, Jörn T, Mohr A, Sixel-Döring F, Trenkwalder C (2007) T2*-weighted MRI in diagnosis of multiple system atrophy. A practical approach for clinicians. J NEUROL, 254(9): 1184-8.
  15. Werner C, Brunner E (2007) Rank methods for the analysis of clustered data in diagnostic trials. COMPUT STAT DATA AN, 51(10): 5041-54.
  16. Wiegand A, Stock A, Attin R, Werner C, Attin T (2007) Impact of the acid flow rate on dentin erosion. J DENT, 35(1): 21-7.
  17. Wiegand A, Wegehaupt F, Werner C, Attin T (2007) Susceptibility of acid-softened enamel to mechanical wear-- ultrasonication versus toothbrushing abrasion. CARIES RES, 41(1): 56-60.


  1. Attin R, Ilse A, Werner C, Wiegand A, Attin T (2006) Antimicrobial effectiveness of a highly concentrated chlorhexidine varnish treatment in teenagers with fixed orthodontic appliances. ANGLE ORTHOD, 76(6): 1022-7.
  2. Betke H, Kahler E, Reitz A, Hartmann G, Lennon A, Attin T (2006) Influence of bleaching agents and desensitizing varnishes on the water content of dentin. OPER DENT, 31(5): 536-42.
  3. Bünger J, Schappler-Scheele B, Hilgers R, Hallier E (2006) A 5-year follow-up study on respiratory disorders and lung function in workers exposed to organic dust from composting plants. INT ARCH OCC ENV HEA, 80(4): 306-12.
  4. Chen TW, Lin BJ, Brunner E, Schild D (2006) In situ background estimation in quantitative fluorescence imaging. BIOPHYS J, 90(7): 2534-47.
  5. Christiansen H, Hermann RM, Martin A, Florez R, Kahler E, Nitsche M, Hille A, Steiner W, Hess CF, Pradier O (2006) Long-term follow-up after transoral laser microsurgery and adjuvant radiotherapy for advanced recurrent squamous cell carcinoma of the head and neck. INT J RADIAT ONCOL, 65(4): 1067-74.
  6. Frosch KH, Drengk A, Krause P, Viereck V, Miosge N, Werner C, Schild D, Stürmer EK, Stürmer KM (2006) Stem cell-coated titanium implants for the partial joint resurfacing of the knee. BIOMATERIALS, 27(12): 2542-9.
  7. Hannig C, Duong S, Becker K, Brunner E, Kahler E, Attin T (2006) Effect of bleaching on subsurface micro-hardness of composite and a polyacid modified composite. DENT MATER, 23(3): 198-203.
  8. Koziolek MJ, Gauczinski S, Kahler E, Bramlage CP, Scheel AK, Mueller GA, Strutz F (2006) Bioimpedance analysis and intradialytic hypotension in intermittent hemodialysis. CLIN NEPHROL, 66(1): 39-50.
  9. Kretschmer L, Hilgers R (2006) Research Supports the View that Sentinel Node Biopsy Is the Standard of Care in High-Risk Primary Melanoma. J CLIN ONCOL, 24(18): 2965-6.
  10. Kunze E, Von Bonin F, Werner C, Wendt M, Schlott T (2006) Transitional cell carcinomas and nonurothelial carcinomas of the urinary bladder differ in the promoter methylation status of the caveolin-1, hDAB2IP and p53 genes, but not in the global methylation of Alu elements. INT J MOL MED, 17(1): 3-13.
  11. Landgrebe J, Bretz F, Brunner E (2006) Efficient design and analysis of two colour factorial microarray experiments. COMPUT STAT DATA AN, 50(2): 499-517.
  12. Mollenhauer B, Bibl M, Wiltfang J, Steinacker P, Ciesielczyk B, Neubert K, Trenkwalder C, Otto M (2006) Total tau protein phosphorylated tau (181p) protein beta-amyloid(1-42), and beta-amyloid(1-40) in cerebrospinal fluid of patients with dementia with Lewy bodies. CLIN CHEM LAB MED, 44(2): 192-5.
  13. Obenauer S, Sohns C, Werner C, Grabbe E (2006) Impact of breast density on computer-aided detection in full-field digital mammography. J DIGIT IMAGING, 19(3): 258-63.
  14. Obenauer S, Sohns C, Werner C, Grabbe E (2006) Computer-aided detection in full-field digital mammography: detection in dependence of the BI-RADS categories. Breast J, 12(1): 16-9.
  15. Olthoff A, Steuer-Vogt MK, Licht K, Sauer-Goenen M, Werner C, Ambrosch P (2006) Quality of life after treatment for laryngeal carcinomas. ORL J OTO-RHINO-LARY, 68(5): 191-196.
  16. Penkalla R, Bedke J, Hemmerlein B, Kahler E, Strauss A, Zöller GM, Heuser M (2006) Changes of microvascular perfusion during acute ureteral obstruction in the rat kidney - the influence of gastrin releasing peptide. CLIN HEMORHEOL MICRO, 34(4): 519-28.
  17. Pohl D, Krone B, Rostasy K, Kahler E, Brunner E, Lehnert M, Wagner HJ, Gärtner J, Hanefeld F (2006) High seroprevalence of Epstein-Barr virus in children with multiple sclerosis. NEUROLOGY, 67(11): 2063-5.
  18. Scheel AK, Hermann KG, Ohrndorf S, Werner C, Schirmer C, Detert J, Bollow M, Hamm B, Müller GA, Burmester GR, Backhaus M (2006) Prospective 7 year follow up imaging study comparing radiography, ultrasonography, and magnetic resonance imaging in rheumatoid arthritis finger joints. ANN RHEUM DIS, 65(5): 595-600.
  19. Schünemann M, Heidrich G, Sahlmann CO, Siefker U, Luig H, Werner C, Brunner E, Meller J (2006) [Improvement of tomographic reconstruction in bone SPECT]. NUKLEARMED-NUCL MED, 45(1): 35-40.
  20. Stoehr GA, Sobh JN, Luecken J, Heidemann K, Mittler U, Hilgers R, Eber SW (2006) Near-total splenectomy for hereditary spherocytosis: clinical prospects in relation to disease severity. BRIT J HAEMATOL, 132(6): 791-3.
  21. Viereck V, Nebel M, Bader W, Harms L, Lange R, Hilgers R, Emons G (2006) Role of bladder neck mobility and urethral closure pressure in predicting outcome of tension-free vaginal tape (TVT) procedure. ULTRASOUND OBST GYN, 28(2): 214-20.
  22. Viereck V, Pauer HU, Hesse O, Bader W, Tunn R, Lange R, Hilgers R, Emons G (2006) Urethral hypermobility after anti-incontinence surgery - a prognostic indicator? INT UROGYNECOL J, 17(6): 586-92.
  23. Wiegand A, Caspar C, Becker K, Werner C, Attin T (2006) [In vitro cytotoxicity of different self-etching dental adhesive systems]. Schweiz Monatsschr Zahnmed, 116(6): 614-21.
  24. Wiegand A, Müller J, Werner C, Attin T (2006) Prevalence of erosive tooth wear and associated risk factors in 2-7-year-old German kindergarten children. ORAL DIS, 12(2): 117-24.
  25. Yakut T, Schulten HJ, Demir A, Frank D, Danner B, Egeli U, Gebitekin C, Kahler E, Gunawan B, Urer N, Oztürk H, Füzesi L (2006) Assessment of molecular events in squamous and non-squamous cell lung carcinoma. LUNG CANCER, 54(3): 293-301.