Institut für Medizinische Statistik - UMG



  1. Huber C, Benda N, Friede T (2020) Subgroup identification in individual patient data meta-analysis using model-based recursive partitioning. [Preprint]
  2. Friedrich S, Antes G, Behr S, Binder H, Brannath W, Dumpert F, Ickstadt K, Kestler H, Lederer J, Leitgöb H, Pauly M, Steland A, Wilhelm A, Friede T (2020) Is there a role for statistics in artificial intelligence? [Preprint]
  3. Röver C, Bender R, Dias S, Schmid CH, Schmidli H, Sturtz S, Weber S, Friede T (2020) On weakly informative prior distributions for the heterogeneity parameter in Bayesian random-effects meta-analysis. [Preprint]
  4. Huang A, Komukai S, Friede T, Hattori S (2020) Using clinical trial registries to inform Copas selection model for publication bias in meta-analysis. [Preprint]
  5. Röver C, Friede T (2020) Bounds for the weight of external data in shrinkage estimation. [Preprint]
  6. Günhan BK, Weber S, Seroutou A, Friede T (2020) Sequential phase I dose-escalation trials with multiple schedules. [Preprint]
  7. Henmi M, Hattori S, Friede T (2020) A confidence interval robust to publication bias for random-effects meta-analysis of few studies. [Preprint]
  8. Stegherr R, Schmoor C, Lübbert M, Friede T, Beyersmann J (2020) Estimating and comparing adverse event probabilities in the presence of varying follow-up times and competing events. [Preprint]
  9. Röver C (2017) Bayesian random-effects meta-analysis using the bayesmeta R package. (Submitted for publication). [Preprint]

    In press

  1. Khan MS, Khan MAA, Irfan S, Siddiqi TJ, Greene SJ, Anker SD, Sreenivasan J, Friede T, Tahhan AS, Vaduganathan M, Fonarow GC, Butler J (2020) Reporting and interpretation of subgroup analyses in heart failure randomized controlled trials. ESC Heart Failure (in press, available online).
  2. Ponikowski P, Kirwan BA, Anker SD, McDonagh T, Dorobantu M, Drozdz J, Fabien V, Filippatos G, Göhring UM, Keren A, Khintibidze I, Kragten H, Martinez FA, Metra M, Milicic D, Nicolau JC, Ohlsson M, Parkhomenko A, Pascual-Figal DA, Ruschitzka F, Sim D, Skouri H, van der Meer P, Lewis B, Comin-Colet J, von Haehling S, Cohen-Solal A, Danchin N, Doehner W, Dargie HJ, Motro M, Butler J, Friede T, Jensen K, Pocock S, Jankowska EA on behalf of the AFFIRM-AHF investigators (2020) Ferric Carboxymaltose for iron deficiency at discharge after acute heart failure: a multicentre, double-blind, randomised, controlled trial. Lancet (in press, available online).
  3. Günhan BK, Meyvisch P, Friede T (2020) Shrinkage estimation for dose-response modeling in phase II trial with multiple schedules. (in press, preprint available).
  4. Frenz AK, Ahlers C, Beckert V, Gerlinger C, Friede T (2020) Predicting menstrual bleeding patterns with levonorgestrel-releasing intrauterine systems. The European Journal of Contraception & Reproductive Health Care (in press).
  5. Friedrich S, Friede T (2020) Causal inference methods for small non-randomized studies: Methods and an application in COVID-19 (in press, preprint available.)
  6. Brunner E, Konietschke F, Bathke AC, Pauly M (2020) Ranks and Pseudo-ranks—Surprising Results of Certain Rank Tests in Unbalanced Designs. International Statistical Review (in press, available online).
  7. Boeckhaus J, Hoefele J, Riedhammer KM, Tönshoff B, Ehren R, Pape L, Latta K, Fehrenbach H, Lange-Sperandio B, Kettwig M, Hoyer P, Staude H, Konrad M, John U, Gellermann J, Hoppe B, Galiano M, Gessner M, Pohl M, Bergmann C, Friede T, Gross O for the GPN Study Group and EARLY PRO-TECT Alport Investigators (2020) Precise variant interpretation, phenotype ascertainment and genotype-phenotype correlation of children in the EARLY PRO-TECT Alport trial. Clinical Genetics (in press, available online).
  8. Mütze T, Friede T (2020) Data monitoring committees for clinical trials evaluating treatments of COVID-19 (in press, available online).
  9. Stegherr R, Beyersmann J, Jehl V, Rufibach K, Leverkus F, Schmoor C, Friede T on behalf of the SAVVY project group (2020) Survival analysis for AdVerse events with VarYing follow-up times (SAVVY): Rationale and statistical concept of a meta-analytic study. Biometrical Journal (in press, preprint available).
  10. Müller F, Hummers E, Hillermann N, Dopfer C, Jablonka A, Friede T, Simmenroth A, Wetzke M (2020) Factors Influencing the Frequency of Airway Infections in Underage Refugees: A Retrospective, Cross Sectional Study. International Journal of Environmental Research and Public Health (in press, available online).
  11. Ursino M, Röver C, Zohar S, Friede T (2020) Random-effects meta-analysis of phase I dose-finding studies using stochastic process priors. (accepted, preprint available.)
  12. Mollenhauer B, Dakna M, Kruse N, Galasko D, Foroud T, Zetterberg H, Schade S, Gera RG, Wang W, Gao F, Frasier M, Chahine LM, Coffey CS, Singleton AB, Simuni T, Weintraub D, Seibyl J, Toga AW, Tanner CM, Kieburtz K, Marek K, Siderowf A, Cedarbaum JM, Hutten SJ, Trenkwalder C, Graham D (2020)Validation of Serum Neurofilament Light Chain as a Biomarker of Parkinson’s Disease Progression Movement Disorders (in press, available online).
  13. Friede T, Stallard N, Parsons N (2020) Seamless phase II/III clinical trials using early outcomes for treatment or subgroup selection: Methods and aspects of their implementation. (in press, available online).
  14. NGAL Meta-Analysis Investigator Group, Albert C, Zapf A, Haase M, Röver C, Pickering JW, Albert A, Bellomo R, Breidthardt T, Camou F, Chen Z, Chocron S, Cruz D, de Geus HR, Devarajan P, Di Somma S, Doi K, Endre ZH, Garcia-Alvarez M, Hjortrup PB, Hur M, Karaolanis G, Kavalci C, Kim H, Lentini P, Liebetrau C, Lipcsey M, Mårtensson J, Müller C, Nanas S, Nickolas TL, Pipili C, Ronco C, Rosa-Diez GJ, Ralib A, Soto K, Braun-Dullaeus RC, Heinz J, Haase-Fielitz A (2020) Neutrophil Gelatinase-Associated Lipocalin Measured on Clinical Laboratory Platforms for the Prediction of Acute Kidney Injury and the Associated Need for Dialysis Therapy: A Systematic Review and Meta-analysis. American Journal of Kidney Diseases (in press, available online)
  15. Evangelou N, Garjani A, das Nair R, Hunter R, Tuite-Dalton K, Craig E, Rodgers WJ, Coles A, Dobson R, Duddy M, Ford D, Hughes S, Pearson O, Middleton L, Rog D, Tallantyre E, Friede T, Middleton R, Nicholas R, and the UK MS Register Research Group (2020) Self-diagnosed COVID-19 in people with multiple sclerosis: a community-based cohort of the UK MS Register. Journal of Neurology, Neurosurgery and Psychiatry (in press, available online).
  16. Ellenberger D, Lausen B, Friede T (2020) Exact change point detection with improved power in small sample binomial sequences. Biometrical Journal (in press, available online).
  17. Scholz KH, Lengenfelder B, Thilo C, Jeron A, Stefanow S, Janssens U, Bauersachs J, Schulze PC, Winter KD, Schröder J, vom Dahl J, von Beckerath N, Seidl K, Friede T, Meyer T (2020) Impact of COVID-19 outbreak on regional STEMI care in Germany. Clinical Research in Cardiology (in press, available online)
  18. Stallard N, Hampson L, Benda N, Brannath W, Burnett T, Friede T, Kimani PK, Koenig F, Krisam J, Mozgunov P, Posch M, Wason J, Wassmer G, Whitehead J, Williamson SF, Zohar S, Jaki T (2020) Efficient adaptive designs for clinical trials of interventions for COVID-19. Statistics in Biopharmaceutical Research (in press, available online).
  19. Zabel M, Willems R, Lubinski A, Bauer A, Brugada J, Conen D, Flevari P, Hasenfuß G, Hatala R, Huikuri HV, Malik M, Pavlovic N, Schmidt G, Sritharan R, Schlögl S, Szavits-Nossan J, Traykov V, Tuinenburg AE, Willich SN, Harden M, Friede T, Svendsen JH, Sticherling C, Merkely B (2020) Clinical effectiveness of primary prevention implantable cardioverter defibrillators: Results of the EU-CERT-ICD controlled multicentre cohort study. European Heart Journal (in press, available online).
  20. Abdelhak A, Huss A, Stahmann A, Senel M, Krumbholz M, Kowarik MC, Havla J, Kümpfel T, Kleiter I, Wuestinger I, Zettl UK, Schwartz M, Rösler R, Friede T, Ludolph AC, Ziemann U, Tumani H (2020) Explorative study of emerging blood biomarkers in progressive multiple sclerosis (EmBioProMS): Design of a prospective observational multicentre pilot study. Contemporary Clinical Trials Communications (in press, available online).
  21. Falk V, Friede T (2020) Noninferiority trials: What's clinically (ir)relevant? The Journal of Thoracic and Cardiovascular Surgery (in press, available online)
  22. Scholz KH, Lengenfelder B, Jacobshagen C, Fleischmann C, Moehlis H, Olbrich HG, Jung J, Maier LS, Maier SKG, Bestehorn K, Friede T, Meyer T (2020) Long-term effects of a standardized feedback-driven quality improvement program for timely reperfusion therapy in regional STEMI care networks. European Heart Journal: Acute Cardiovascular Care (in press).
  23. Zabel M, Schlögl S, Lubinski A, Svendsen J, Bauer A, Arbelo E, Brusich S, Conen D, Cygankiewicz I, Dommasch M, Flevari P, Galuszka J, Katsimardos A, Hansen J, Hasenfuss G, Hatala R, Huikuri H, Kentta T, Kuczejko T, Haarmann H, Harden M, Iovev S, Kääb S, Kaliska G, Kasprzak JD, Qavoq D, Luthje L, Malik M, Novotny T, Pavlovic N, Perge P, Röver C, Schmidt G, Shalganov T, Sritharan R, Svetlosak M, Sallo Z, Szavits‑Nossan J, Traykov V, Vandenberk B, Velchev V, Vos M, Willich SN, Friede T, Willems R, Merkely B, Sticherling C (2019) Present criteria for prophylactic ICD implantation: Insights from the EU-CERT-ICD (Comparative Effectiveness Research to Assess the Use of Primary ProphylacTic Implantable Cardioverter Defibrillators in EUrope) project. Journal of Electrocardiology (in press, available online).



  1. Vach W, Bibiza-Freiwald E, Gerke O, Bossuyt P, Friede T, Zapf A (2021) A potential for seamless designs in diagnostic research could be identified. Journal of Clinical Epidemiology 129: 51-59. [Open Access]



  1. Otte C, Chae WR, Nowacki J, Märschenz S, Lischewski S, Schmidt S, Ettrich B, Grabe HJ, Hinkelmann K, Hofmann T, Janowitz D, Junghanns K, Kahl KG, Klein JP, Krüger THC, Leicht G, Prvulovic D, Reif A, Röpke S, Schöttle D, Strauß M, Westermair A, Friede T, Gold SM (2020) Simvastatin add-on to escitalopram in patients with comorbid obesity and major depression (SIMCODE): study protocol of a multicenter, randomized, double-blind, placebo-controlled trial. BMJ Open. 10:e040119. [Open Access]
  2. Vandenberk B, Floré V, Röver C, Vos M, Friede T, Flevari P, Zabel M, Willems R (2020) Repeating non-invasive risk stratification improves prediction of outcome in ICD patients. Annals of Noninvasive Electrocardiology. [Open Access]
  3. Schlotawa L, Preiskorn J, Ahrens-Nicklas R, Schiller S, Adang LA, Gärtner J, Friede T (2020) A systematic review and meta-analysis of published cases reveals the natural disease history in Multiple Sulfatase Deficiency. Journal of Inherited Metabolic Disease 43:1288–1297. [Open Access]
  4. Günhan BK, Weber S, Friede T (2020) A Bayesian time-to-event pharmacokinetic model for phase I dose-escalation trials with multiple schedules. Statistics in Medicine 39: 3986–4000. [Open Access]
  5. Mütze T, Salem S, Benda N, Schmidli H, Friede T (2020) Blinded continuous information monitoring of recurrent event endpoints with time trends in clinical trials. Statistics in Medicine 39: 3968–3985. [Abstract]
  6. Stoppe C, van Gassel R, Jonckheer J, Garcia Velasquez ME, Di Girolamo FG, Chapela SP, Wichansawakum S, Albay Jr A, Friede T, Martindale R, Berger MM (2020) First international meeting of early career investigators: current opportunities, challenges and horizon in critical care nutrition research. Clinical Nutrition ESPEN. 20: 92-100. [Open Access]
  7. Mueller C, Hesjedal-Streller B, Fleischmann N, Tetzlaff B, Mallon T, Scherer M, Köpke S, Balzer K, Gärtner L, Maurer I, Friede T, König HH, Hummers E (2020) Effects of strategies to improve general practitioner-nurse collaboration and communication in regard to hospital admissions of nursing home residents (interprof ACT): Study protocol for a cluster-randomised controlled trial. Trials 21: 913. [Open access]
  8. Kunz CU, Jörgens S, Bretz F, Stallard N, Van Lancker K, Xi D, Zohar S, Gerlinger C, Friede T (2020) Clinical trials impacted by the COVID-19 pandemic: Adaptive designs to the rescue? Statistics in Biopharmaceutical Research. 12: 461-477. [Open Access]
  9. Stallard N, Hampson L, Benda N, Brannath W, Burnett T, Friede T, Kimani PK, Koenig F, Krisam J, Mozgunov P, Posch M, Wason J, Wassmer G, Whitehead J, Williamson SF, Zohar S, Jaki T (2020) Efficient adaptive designs for clinical trials of interventions for COVID-19. Statistics in Biopharmaceutical Research. 12: 483-497. [Open Access]
  10. Heinz J, Röver C, Furaijat G, Kaußner Y, Hummers E, Debray TPA, Hay AD, Heytens S, Vik I, Little P, Moore M, Stuart B, Wagenlehner F, Kronenberg A, Ferry S, Monsen T, Lindbaek M, Friede T, Gágyor I (2020) Strategies to reduce antibiotic use in women with uncomplicated urinary tract infection in primary care: Protocol of a systematic review and meta-analysis including individual patient data. BMJ Open 10: e035883. [Open access]
  11. Harden M, Friede T (2020) Sample size reestimation in multi-centre randomized controlled clinical trials based on non-comparative data. Biometrical Journal. 62: 1284–1299. [Open Access]
  12. Friede T, Stallard N, Parsons N (2020) Adaptive seamless clinical trials using early outcomes for treatment or subgroup selection: Methods, simulation model and their implementation in R. Biometrical Journal. 62: 1264– 1283. [Open Access]
  13. Meaidi A, Friedrich S, Lidegaard Ø (2020) Risk of surgical evacuation and risk of major surgery following second-trimester medical abortion in Denmark: A nationwide cohort study Contraception. 102: 201-206. [Full text]
  14. Judd N, Sauce B, Wiedenhoeft J, Tromp J, Chaarani B, Schliep A, van Noort B, Penttilä J, Grimmer Y, Insensee C, Becker A, Banaschewski T, Bokde ALW, Quinlan EB, Desrivières S, Flor H, Grigis A, Gowland P, Heinz A, Ittermann B, Martinot JL, Paillère Martinot ML, Artiges E, Nees F, Papadopoulos Orfanos D, Paus T, Poustka L, Hohmann S, Millenet S, Fröhner JH, Smolka MN, Walter H, Whelan R, Schumann G, Garavan H, Klingberg T (2020) Cognitive and brain development is independently influenced by socioeconomic status and polygenic scores for educational attainment. Proceedings of the National Academy of Sciences. 117: 12411-12418. [Full text]
  15. Khan MS, Fonarow GC, Friede T, Lateef N, Khan SU, Anker S, Harrell FE, Butler J (2020) Reverse Fragility Index of Statistically Non-Significant Clinical Trial Results. JAMA Network Open. 3: e2012469. [Open Access]
  16. Gross O, Tönshoff B, Weber LT, Pape L, Latta K, Fehrenbach H, Lange-Sperandio B, Zappel H, Hoyer P, Staude H, König S, John U, Gellermann J, Hoppe B, Galiano M, Hoecker B, Ehren R, Lerch C, Kashtan CE, Harden M, Boeckhaus J, Friede T (2020) A multicenter, randomized, placebo-controlled, double-blind phase 3 trial with open-arm comparison indicates safety and efficacy of nephroprotective therapy with ramipril in children with Alport’s syndrome. Kidney International. 97: 1275-1286. [Open Access]
  17. Hermann P, Treig J, Unkel S, Goebel S, Bunck T, Jünemann M, Friede T, Zerr I (2020) Creutzfeldt-Jakob disease among German physicians, 1993-2018. Emerging Infectious Diseases. 26: 1710-1719. [Open Access]
  18. Busold-Hagenbeck D, Elmenhorst J, von Brenndorff CI, Hilgers R, Hulpke-Wette M (2020) Frequency and individual severity of arterial blood pressure changes in children and adolescents with attentiondeficit/hyperactivity disorder treated with methylphenidate hydrochloride: a prospective non-interventional study.General Psychiatry 33: e100193. [Open Access]
  19. Cole J, Raffel J, Friede T, Eshaghi A, Brownlee W, Chard C, De Stefano N, Enzinger C, Pipramer L, Filippi M, Gasperini C, Rocca MA, Rovira A, Ruggieri S, Sastre-Garriga J, Stromillo ML, Uitdehaag B, Vrenken H, Barkhof F, Nicholas R, Ciccarelli O on behalf of the MAGNIMS study group (2020) Longitudinal assessment of multiple sclerosis with the brain-age paradigm. Annals of Neurology 88: 93–105. [Open Access]
  20. Anker SD, Butler J, Khan MS, Abraham W, Bauersachs J, Bocchi E, Bozkurt B, Braunwald E, Chopra VK, Cleland JG, Ezekowitz J, Filippatos G, Friede T, Hernandez A, Lam CS, Lindenfeld J, McMurray JJ, Mehra M, Metra M, O’Connor C, Packer M, Pieske B, Pocock S, Ponikowski P, Rosano GMC, Teerlink J, Tsutsui H, Van Veldhuisen DJ, Verma S, Voors AA, Wittes J, Zannad F, Zhang J, Seferovic P, Coats AJS (2020) Conducting Clinical Trials in Heart Failure During (and After) the COVID-19 Pandemic: An Expert Consensus Position Paper from the Heart Failure Association (HFA) of the European Society of Cardiology (ESC). European Heart Journal 41: 2109–2117. [Open Access]
  21. Ditzhaus M, Friedrich S (2020) More powerful logrank permutation tests for two-sample survival data. Journal of Statistical Computation and Simulation 90: 2209-2227. [Full text]
  22. Pelli A, Kenttä TV, Junttila MJ, Bergau L, Zabel M, Malik M, Reichlin T, Willems R, Vos MA, Harden M, Friede T, Sticherling C, Huikuri HV (2020) Electrocardiogram as a predictor of survival without appropriate shocks in primary prophylactic ICD patients: A retrospective multi-center study. International Journal of Cardiology 309: 78-83. [Full text]
  23. Zapf A, Asendorf T, Anten C, Mütze T, Friede T (2020) Blinded sample size reestimation for negative binomial regression with baseline adjustment. Statistics in Medicine 39: 1980–1998. [Open Access]
  24. Voormolen DC, Zeldovich M, Haagsma JA, Polinder S, Friedrich S, Maas AI, Wilson L, Steyerberg EW, Covic A, Andelic N, Plass AM, Wu YJ, Asendorf T, von Steinbüechel N (2020) Outcomes after Complicated and Uncomplicated Mild Traumatic Brain Injury at Three-and Six-Months Post-Injury: Results from the CENTER-TBI Study. Journal of Clinical Medicine 9: 1525. [Open Access]
  25. Scholz KH, Friede T, Meyer T, Jacobshagen C, Lengenfelder B, Jung J, Fleischmann C, Moehlis H, Olbrich HG, Ott R, Elsässer A, Schröder S, Thilo C, Raut W, Franke A, Maier LS, Maier SKG (2020) Prognostic significance of emergency department bypass in stable and unstable patients with ST-segment elevation myocardial infarction. European Heart Journal: Acute Cardiovascular Care 9: 34-44. [Open Access]
  26. Bergau P, Schirmer MA, Leha A, Leu M, Emons G, Hess CF, Hille A (2020). The impact of rectal/bladder filling and applicator positioning on in vivo rectal dosimetry in vaginal cuff brachytherapy using an enhanced therapy setting. Brachytherapy 19: 168-175. [Full text]
  27. Zapf A, Stark M, Gerke O, Ehret C, Benda N, Bossuyt P, Deeks J, Reitsma J, Alonzo T, Friede T (2020) Adaptive trial designs in diagnostic accuracy research. Statistics in Medicine 39: 515 – 674. [Open Access]
  28. Konietzka J, Fritz M, Spiri S, McWhirter R, Leha A, Palumbos S, Steuer Costa W, Oranth A, Gottschalk A, Miller DM, Hajnal A, Bringmann H (2020) Epidermal Growth Factor signaling acts directly and through a sedation neuron to depolarizes a sleep-active neuron following cellular stress. Current Biology 30: 1-16.e13. [Abstract]
  29. Junttila MJ, Pelli A, Kenttä TV, Friede T, Willems R, Bergau L, Malik M, Vandenberk B, Vos MA, Schmidt G, Merkely B, Lubinski A, Svetlosak M, Braunschweig F, Harden M, Zabel M, Huikuri HV, Sticherling C (2020) Appropriate Shocks and Mortality in Patients With Versus Without Diabetes With Prophylactic Implantable Cardioverter Defibrillators Diabetes Care 43: 196-200. [Abstract]
  30. Röver C, Friede, T (2020) Dynamically borrowing strength from another study through shrinkage estimation. Statistical Methods in Medical Research 29: 293-308. [Open Access]
  31. Günhan BK, Röver C, Friede T (2020) Meta-analysis of few studies involving rare events. Research Synthesis Methods 11: 74-90. [Open Access]
  32. Stork L, Ellenberger D, Ruprecht K, Reindl M, Beißbarth T, Friede T, Kümpfel T, Gloth M, Paul F, Brück W, Metz I (2020) Antibody signatures in patients with histopathologically defined multiple sclerosis patterns. Acta Neuropathologica 139: 547-564. [Open Access]



  1. Friedrich S, Konietschke F, Pauly M (2019) Analysis of Multivariate Data and Repeated Measures Designs with the R Package MANOVA.RM. The R Journal 11: 380-400. [Open Access]
  2. Fokas E, Allgäuer M, Polat B, Klautke G, Grabenbauer GG, Fietkau R, Kuhnt T, Staib L, Brunner T, Grosu AL, Schmiegel W, Jacobasch L, Weitz J, Folprecht G, Schlenska-Lange A, Flentje M, Germer CT, Grützmann R, Schwarzbach M, Paolucci V, Bechstein W, Friede T, Ghadimi M, Hofheinz RD, Rödel C, on behalf of the German Rectal Cancer Study Group (2019) Randomized phase II trial of chemoradiotherapy plus induction or consolidation chemotherapy as total neoadjuvant therapy for locally advanced rectal cancer: CAO/ARO/AIO-12. Journal of Clinical Oncology 37: 3212-3222. [Full text]
  3. Oellerich M, Shipkova M, Asendorf T, Walson PD, Schauerte V, Mettenmeyer N, Kabakchiev M, Hasche G, Gröne HJ, Friede T, Wieland E, Schwenger V, Schütz E, Beck J (2019) Absolute quantification of donor-derived cell-free DNA as a marker of rejection and graft injury in kidney transplantation - Results from a prospective observational study. American Journal of Transplantation 19: 3087–3099. [Open Access]
  4. Buentzel J, Heinz J, Bleckmann A, Bauer C, Röver C, Bohnenberger H, Saha S, Hinterthaner M, Baraki H, Kutschka I, Emmert A. (2019) Sarcopenia as Prognostic Factor in Lung Cancer Patients: A Systematic Review and Meta-analysis. Anticancer Research 39: 4603-4612. [Full text]
  5. Brehm A, Maus V, Tsogas I, Colla R, Hesse AC, Gera RG, Psychogios MN (2019) Stent-retriever Assisted Vacuum-Locked Extraction (SAVE) Versus a Direct Aspiration First Pass Technique (ADAPT) for Acute Stroke: Data From the Real-World. BMC Neurology 19: 65. [Open Access]
  6. Fehling P, Hasenkamp J, Unkel S, Thalmann I, Hornig S, Trümper L, Scheithauer S (2019) Effect of gloved hand disinfection on hand hygiene before infection-prone procedures on a stem cell ward. Journal of Hospital Infection 103: 321-327. [Abstract]
  7. Boerger M, Funke S, Leha A, Roser AE, Wuestemann AK, Maass F, Bähr M, Grus F, Lingor P (2019). Proteomic analysis of tear fluid reveals disease-specific patterns in patients with Parkinson's disease - A pilot study. Parkinsonism & related disorders 63: 3–9. [Full text]
  8. Bauer A, Klemm M, Rizas KD, Hamm W, von Stülpnagel L, Dommasch M, Steger A, Lubinski A, Flevari P, Harden M, Friede T, Kääb S, Merkely B, Sticherling C, Willems R, Huikuri H, Malik M, Schmidt G, Zabel M (2019) Prediction of mortality benefit based on periodic repolarisation dynamics in patients undergoing prophylactic implantation of a defibrillator: a prospective, controlled, multicentre cohort study. The Lancet 394:1344-1351. [Abstract]
  9. Chereda H, Bleckmann A, Kramer F, Leha A, Beissbarth T (2019). Utilizing Molecular Network Information via Graph Convolutional Neural Networks to Predict Metastatic Event in Breast Cancer. Studies in health technology and informatics 267: 181–186. [Full text]
  10. Bobenko A, Schoenrath F, Knierim JH, Friede T, Verheyen N, Mehra MR, Haykowsky M, Herrmann-Lingen C, Duvinage A, Pieske-Kraigher E, Halle M, Falk V, Pieske B, Edelmann F (2019) Exercise training in patients with a left ventricular assist device (Ex-VAD): rationale and design of a multicentre, prospective, assessor-blinded, randomized, controlled trial. European Journal of Heart Failure 21: 1152-1159. [Open Access]
  11. Behme D, Gera RG, Tsogkas I, Colla R, Liman J, Maier IL, Liebeskind DS, Psychogios MN (2019) Impact of Time on Thrombolysis in Cerebral Infarction Score Results. Clinical Neurocardiology. [Full text]
  12. Nicholas RS, Han E, Raffel J, Chataway J, Friede T (2019) Over three decades study populations in progressive multiple sclerosis have become older and more disabled, but have lower on-trial progression rates: a systematic review and meta-analysis of 43 randomized placebo-controlled trials. Multiple Sclerosis Journal 25: 1462-1471. [Abstract]
  13. Graf AC, Wassmer G, Friede T, Gera RG, Posch M (2019) Robustness of testing procedures for confirmatory subpopulation analyses based on a continuous biomarker. Statistical Methods in Medical Research 28: 1879–1892. [Open Access]
  14. Behme D, Tsogkas I, Colla R, Gera RG, Schregel K, Hesse AC, Maier IL, Liman J, Liebeskind DS, Psychogios MN (2019) Validation of the extended thrombolysis in cerebral infarction score in a real world cohort. PLoS One 14: e0210334. [Open Access]
  15. Krombach J, Hennel R, Brix N, Orth M, Schoetz U, Ernst A, Schuster J, Zuchtriegel G, Reichel CA, Bierschenk S, Sperandio M, Vogl T, Unkel, S, Belka C, Lauber K (2018) Priming anti-tumor immunity by radiotherapy: Dying tumor cell-derived DAMPs trigger endothelial cell activation and recruitment of myeloid cells. Oncoimmunology 8: e1523097. [Open access]
  16. Rommer PS, Eichstädt K, Ellenberger D, Flachenecker P, Friede T, Haas J, Kleinschnitz C, Pöhlau D, Rienhoff O, Stahmann A, Zettl UK (2019) Symptomatology and symptomatic treatment in multiple sclerosis: results from a nationwide MS registry. Multiple Sclerosis Journal 25: 1641–1652. [Abstract]
  17. Götz MR, Collado JA, Fernández-Ruiz J, Fiebich BL, García-Toscano L, Gómez-Cañas M, Koch O, Leha A, Muñoz E, Navarrete C, Pazos MR, Holzgrabe U (2019) Structure-Effect Relationships of Novel Semi-Synthetic Cannabinoid Derivatives. Frontiers in pharmacology 10: 1284. [Full text]
  18. Leha A, Hellenkamp K, Unsöld B, Mushemi-Blake S, Shah AM, Hasenfuß G, Seidler T (2019). A machine learning approach for the prediction of pulmonary hypertension. PloS one, 14: e0224453. [Open access]
  19. Masanta WO, Zautner AE, Lugert R, Bohne W, Gross U, Leha A, Dakna M, Lenz C (2019) Proteome Profiling by Label-Free Mass Spectrometry Reveals Differentiated Response of Campylobacter jejuni 81–176 to Sublethal Concentrations of Bile Acids. Proteomics Clinical Applications 13: 1800083. [Open Access]
  20. Pringsheim M, Mitter D, Schröder S, Warthemann R, Plümacher K, Kluger G, Baethmann M, Bast T, Braun S, Büttel HM, Conover E, Courage C, Datta AN, Eger A, Grebe TA, Hasse-Wittmer A, Heruth M, Höft K, Kaindl AM, Karch S, Kautzky T, Korenke GC, Kruse B, Lutz RE, Omran H, Patzer S, Philippi H, Ramsey K, Rating T, Rieß A, Schimmel M, Westman R, Zech FM, Zirn B, Ulmke PA, Sokpor G, Tuoc T, Leha A, Staudt M, Brockmann K (2019). Structural brain anomalies in patients with FOXG1 syndrome and in Foxg1+/- mice. Annals of Clinical Translational Neurology 6: 655-668. [Open access]
  21. Vigilante A, Laddach A, Moens N, Meleckyte R, Leha A, Ghahramani A, Culley OJ, Kathuria A, Hurling C, Vickers A, Wiseman E, Tewary M, Zandstra PW; HipSci Consortium, Durbin R, Fraternali F, Stegle O, Birney E, Luscombe NM, Danovi D, Watt FM (2019)Identifying Extrinsic versus Intrinsic Drivers of Variation in Cell Behavior in Human iPSC Lines from Healthy Donors. Cell Reports 26: 2078-2087.e3. [Open Access]
  22. Barbara V, Leinemann L, Peters FS, Wolff A, Leha A, Salinas G, Schumacher J, Gailing O (2019) Response of Scots Pine (Pinus Sylvestris) Seedlings Subjected to Artificial Infection with the Fungus Sphaeropsis Sapinea. Plant Molecular Biology Reporter 37: 214–23. [Full text]
  23. Posch M, Bretz F, Friede T, Heinze G (2019) Quantitative approaches underpinning decision making. Biometrical Journal 61: 1103. [Open Access]
  24. Wulf G, Hasenkamp J, Jung W, Wilhelm C, Held G, Nickelsen M, Leha A, Pfreundschuh M, Schmitz N, Trümper L, Glass B (2019) Allogeneic stem cell transplantation for patients with relapsed or refractory T-cell lymphoma: efficacy of lymphoma-directed conditioning against advanced disease. Bone marrow transplantation 54: 877–884. [Full tetx]
  25. Andreas S, Röver C, Heinz J, Straube S, Watz H, Friede T (2019) Decline of COPD exacerbations in clinical trials over two decades - a systematic review and meta-regression. Respiratory Research 20:186. [Open Access]
  26. Mütze T, Glimm E, Schmidli H, Friede T (2019) Group sequential designs with robust semiparametric recurrent event models. Statistical Methods in Medical Research 28: 2385–2403. [Abstract]
  27. Mütze T, Glimm E, Schmidli H, Friede T (2019). Group sequential designs for negative binomial outcomes. Statistical Methods in Medical Research 28: 2326–2347. [Abstract]
  28. Huber C, Benda N, Friede T (2019) A comparison of subgroup identification methods in clinical drug development: Simulation study and regulatory considerations. Pharmaceutical Statistics 18: 600-626. [Open Access]
  29. Placzek M, Friede T (2019) A conditional error function approach for adaptive enrichment designs with continuous endpoints. Statistics in Medicine 38: 3105-3122. [Abstract]
  30. Friede T, Pohlmann H, Schmidli H (2019) Blinded sample size reestimation in event-driven clinical trials: Methods and an application in multiple sclerosis. Pharmaceutical Statistics 18: 351–365. [Abstract]
  31. Konietschke F, Friede T, Pauly M (2019) Semi-parametric analysis of over-dispersed count and metric data with varying follow-up times: Asymptotic theory and small sample approximations. Biometrical Journal 61: 616–629. [Open Access]
  32. Asendorf T, Henderson R, Schmidli H, Friede T (2019) Sample size reestimation for clinical trials with longitudinal negative binomial counts including time trends. Statistics in Medicine 38: 1503–1528. [Abstract]
  33. Lingor P, Weber M, Camu W, Friede T, Hilgers R, Leha A, Christoph Neuwirth C, Günther R, Benatar M, Kuzma-Kozakiewicz M, Bidner H, Blankenstein C, Frontini R, Ludolph A, Koch JC and the ROCK-ALS Investigators (2019) ROCK-ALS: Protocol for a Randomized, Placebo-Controlled, Double-Blind Phase IIa Trial of Safety, Tolerability and Efficacy of the Rho Kinase (ROCK) Inhibitor Fasudil in Amyotrophic Lateral Sclerosis. Frontiers in Neurology 10: 293. [Open Access]
  34. Unkel S, Amiri M, Benda N, Beyersmann J, Knoerzer D, Kupas K, Langer F, Leverkus F, Loos A, Ose C, Proctor T, Schmoor C, Schwenke C, Skipka G, Unnebrink K, Voss F, Friede T. (2019) On estimands and the analysis of adverse events in the presence of varying follow-up times within the benefit assessment of therapies. Pharmaceutical Statistics 18:166–183. [Open Access]
  35. Ott M, Avendaño-Guzmán E, Ullrich E, Dreyer C, Strauss J, Harden M, Schön M, Schön MP, Bernhardt G, Stadelmann C, Wegner C, Brück W, Nessler S (2019) Laquinimod, a prototypic quinoline-3-carboxamide and aryl hydrocarbon receptor agonist, utilizes a CD155-mediated natural killer/dendritic cell interaction to suppress CNS autoimmunity Journal of Neuroinflammation 16: 49. [Open Access]
  36. Friede T, Häring DA, Schmidli H (2019) Blinded continuous monitoring in clinical trials with recurrent event endpoints. Pharmaceutical Statistics 18: 54–64. [Open Access]
  37. Mollenhauer B, Zimmermann J, Sixel-Döring F, Focke NK, Wicke T, Ebentheuer J, Schaumburg M, Lang E, Friede T, Trenkwalder C on behalf of the DeNoPa Study Group (2019) Baseline predictors for progression in early Parkinson’s disease after 4-year follow-up from the DeNoPa cohort. Movement Disorders 34: 67-77. [Abstract]
  38. Röver C, Wandel S, Friede T. (2019) Model averaging for robust extrapolation in evidence synthesis. Statistics in Medicine 38: 674–694. [Abstract]
  39. Ursino M, Yuan Y, Alberti C, Comets E, Favrais G, Friede T, Lentz F, Stallard N, Zohar S (2019) A dose-finding design for seizure reduction in neonates. Journal of the Royal Statistical Society Series C 68: 427–444. [Open Access]
  40. Zabel M, Sticherling C, Willems R, Lubinski A, Bauer A, Bergau L, Braunschweig F, Brugada J, Brusich S, Conen D, Cygankiewicz I, Flevari P, Taborsky M, Hansen J, Hasenfuß G, Hatala R, Huikuri HV, lovev S, Kääb S, Kaliska G, Jaroslaw D. Kasprzak JD, Lüthje L, Malik M, Novotný T, Pavlovic N, Schmidt G, Shalganov T, Sritharan R, Schlögl S, Szavits-Nossan J, Traykov V, Tuinenburg A, Velchev V, Vos MA, Willich SN, Friede T, Svendsen JH, Merkely B, for the EU-CERT-ICD Study lnvestigators (2018) Rationale and Design of the EU-CERT-ICD Prospective Study: Comparative Effectiveness of Prophylactic ICD Implantation. ESC Heart Failure 6: 182– 193 [Open Access]
  41. Seide SE, Röver C, Friede T (2019) Likelihood-based meta-analysis with few studies: Empirical and simulation studies. BMC Medical Research Methodology 19: 16. [Open Access]
  42. Asendorf T, Henderson R, Schmidli H, Friede T (2019) Modelling and sample size reestimation for longitudinal count data with incomplete follow up. Statistical Methods in Medical Research 28: 117–133. [Abstract]



  1. Gibbons C, Pagnini F, Friede T, Young CA (2018) Treatment of fatigue in amyotrophic lateral sclerosis/motor neuron disease. The Cochrane database of systematic reviews 1: CD011005. [Full text]
  2. Fasshauer M, Krüwel T, Zapf A, Stahnke VC, Rave-Fränk M, Staab W, Sohns JM, Steinmetz M, Unterberg-Buchwald C, Schuster A, Ritter C, Lotz J(2018) Absence of DNA double-strand breaks in human peripheral blood mononuclear cells after 3 Tesla magnetic resonance imaging assessed by γH2AX flow cytometry. European Radiology 28: 1149. [Abstract]
  3. Hesse AC, Behme D, Kemmling A, Zapf A, Hokamp NG, Frischmuth I, Maier I, Liman J, Tsogkas I, Buhk JH, Tran J, Fiehler J, Mpotsaris A, Schramm P, Berlis A, Knauth M, Psychogios MN (2018) Comparing different thrombectomy techniques in five large-volume centers: a 'real world' observational study. Journal of NeuroInterventional Surgery 10: 525-529. [Abstract]
  4. Djukic M, Braun LM, Unkel S, Jacobshagen C, Nau R (2018): Introduction of non-vitamin K antagonist anticoagulants strongly increased the rate of anticoagulation in geriatric patients. Drugs & Aging 35: 859-869. [Abstract]
  5. Harden M, Friede T (2018) Sample size calculation in multi-centre clinical trials. BMC Medical Research Methodology 18:156 [Open Access]
  6. Röver C, Friede T (2018) Contribution to the discussion of "When should meta-analysis avoid making hidden normality assumptions?": A Bayesian perspective. Biometrical Journal 60: 1068-1070. [Abstract]
  7. Stürner KH, Stellmann JP, Dörr J, Paul F, Friede T, Schammler S, Reinhardt S, Siemonsen S, Weisspflog G, Faizy T, Werz O, Fleischer S, Vaaß L, Hermann F, Pless O, Martin R, Heesen C (2018) A standardised frankincense extract reduces disease activity in relapsing-remitting multiple sclerosis in a phase II a trial (The SABA Trial). Journal of Neurology, Neurosurgery and Psychiatry 89: 330–338. [Full text]
  8. Pöttgen J, Moss-Morris R, Wendebourg JM, Feddersen L, Lau S, Köpke S, Meyer B, Friede T, Penner IK, Heesen C, Gold S (2018) Randomised controlled trial of a self-guided online fatigue intervention in multiple sclerosis. Journal of Neurology, Neurosurgery and Psychiatry 89: 970–976. [Abstract]
  9. Maiolo G, Collino F, Vasques F, Rapetti F, Tonetti T, Romitti F, Cressoni M, Chiumello D, Mörer O, Herrmann P, Friede T, Quintel M, Gattinoni L (2018) Reclassifying Acute Respiratory Distress Syndrome. American Journal of Respiratory and Critical Care Medicine 197: 1586-1595. [Abstract]
  10. Bergau L, Willems R, Dunnink A, Tuinenburg AE, Flevari P, Vos MA, Vandenberk B, Wijers SC, Katsaras D, Lüthje L, Seegers J, Sossalla ST, Fischer TH, Röver C, Lehnart SE, Hasenfuß G, Friede T, Zabel M (2018) Differential multivariable risk prediction of appropriate shock versuse competing mortality – A prospective cohort study to estimate benefits from ICD therapy. International Journal of Cardiology 272: 102–107. [Open Access]
  11. Friede T, Posch M, Zohar S, Alberti C, Benda N, Comets E, Day S, Dmitrienko A, Graf A, Gunhan B, Hee SW, Lentz F, Madan J, Miller F, Ondra T, Pearce M, Röver C, Toumazi A, Unkel S, Ursino M, Wassmer G, Stallard N (2018) Recent advances in methodology for clinical trials in small populations: the InSPiRe project. Orphanet Journal of Rare Diseases 13: 186. [Open Access]
  12. Placzek M, Friede T (2018) Clinical trials with nested subgroups: Analysis, sample Size determination and internal pilot studies. Statistical Methods in Medical Research 27: 3286–3303. [Abstract]
  13. Bender R, Friede T, Koch A, Kuß O, Schlattmann P, Schwarzer G, Skipka G (2018) Methods for evidence synthesis in the case of very few studies. Research Synthesis Methods 9: 382–392. [Open Access]
  14. Jo P, Bernhardt M, Nietert M, Azizian A, König A, Wolff HA, Schirmer M, Grade M, Ghadimi M, Ströbel P, Schildhaus HU, Gaedcke J (2018) KRAS Mutationstatus Konkordanz zwischen Primärtumor und der korrespondierenden Metastase in Patienten mit Rektumkarzinom. Zeitschrift für Gastroenterologie 56: e338-e339. [Abstract]
  15. Jo P, Kesruek H, Nietert M, Sahlmann C, Gaedcke J, Ghadimi M, Sperling J (2018) Inzidenz und Prädiktive Faktoren des Bilateralen Papillären Schilddrüsenkarzinoms. Zentralblatt für Chirurgie 143: 361-366. [Abstract]
  16. Stork L, Ellenberger D, Beißbarth T, Friede T, Lucchinetti CF, Brück W, Metz I (2018) Differences in the reponses to apheresis therapy of patients with 3 histopathologically classified immunopathological patterns of multiple sclerosis. JAMA Neurology 75: 428-435. [Full text]
  17. Afshar K, Fleischmann N, Schmiemann G, Bleidorn J, Hummers-Pradier E, Friede T, Wegscheider K, Moore M, Gágyor I (2018) Reducing antibiotic use for uncomplicated urinary tract infection in general practice by treatment with Uva ursi (REGATTA) - a double-blind, randomized, controlled comparative effectiveness trial. BMC Complementary and Alternative Medicine 18: 203. [Open Access]
  18. Sticherling C, Arendacka B, Hastrup Svendsen J, Wijers S, Friede T, Stockinger J, Dommasch M, Merkely B, Willems R, Lubinski A, Scharfe M, Braunschweig F, Svetlosak M, Zürn CS, Huikuri H, Flevari P, Lund-Andersen C, Schaer BA, Tuinenburg AE, Bergau L, Schmidt G, Szeplaki G, Vanderberk B, Kowalczyk E, Eick C, Juntilla J, Conen D, Zabel M for the EU-CERT-ICD investigators (2018) Sex Differences in Outcomes of Primary Prevention ICD Therapy: Combined Registry Data from Eleven European countries. EP Europace 20: 963–970. [Open Access]
  19. Wolff A, Bayerlová M, Gaedcke J, Kube D, Beißbarth T (2018) A comparative study of RNA-Seq and microarray data analysis on the two examples of rectal-cancer patients and Burkitt Lymphoma cells. PLoS One 14: e0224062. [Open Access]
  20. Scholz KH, Maier SKG, Maier LS, Lengenfelder B, Jacobshagen C, Jung J, Fleischmann C, Werner GS, Olbrich HG, Ott R, Mudra H, Seidl K, Schulze C, Weiss C, Zrenner B, Friede T, Meyer T (2018) Impact of treatment delay on mortality in ST-segment elevation myocardial infarction (STEMI) patients presenting with and without haemodynamic instability: results from the German prospective, multicentre FITT-STEMI trial. European Heart Journal 39: 1065–1074. [Open Access]
  21. Mütze T, Schmidli H, Friede T (2018) Sample size re-estimation incorporating prior information on a nuisance parameter. Pharmaceutical Statistics 17: 126-143. [Abstract]
  22. Grimmsmann T, Harden M, Fiß T, Himmel W (2018) The influence of hospitalisation on the initiation, continuation and discontinuation of benzodiazepines and Z-drugs – an observational study. Swiss Med Wkly 148: w14590. [Open Access]
  23. Günhan BK, Friede T, Held L (2018) A design-by-treatment interaction model for network meta-analysis with integrated nested Laplace approximations. Research Synthesis Methods 9:179–194. [Open Access]
  24. Hellenkamp K, Unsöld B, Mushemi-Blake S, Shah AM, Friede T, Hasenfuß G, Seidler T (2018) Echocardiographic estimation of mean pulmonary artery pressure – a comparison of different approaches to assign the likelihood of pulmonary hypertension. Journal of the American Society of Echocardiography 31: 89-98. [Abstract]
  25. Toumazi A., Comets E, Alberti C, Friede T, Lentz F, Stallard N, Zohar S, Ursino M (2018) dfpk: An R-package for Bayesian dose-finding designs using pharmacokinetics (PK) for phase I clinical trials. Computer Methods and Programs in Biomedicine 157: 163–177. [Open Access]



  1. Unkel, S (2017) On the conditional probability for assessing time dependence of association in shared frailty models with bivariate current status data. Journal of Statistical Planning and Inference 182: 1-11. [Abstract]
  2. Unkel, S (2017) On the shape of the cross-ratio function in bivariate survival models induced by truncated and folded normal frailty distributions. Metrika 80: 351-362.[Abstract]
  3. Nikolin VM, Olarte-Castillo XA, Osterrieder N, Hofer H, Dubovi E, Mazzoni CJ, Brunner E, Goller KV, Fyumagwa RD, Moehlman PD, Thierer D, East ML (2017) Canine distemper virus in the Serengeti ecosystem: molecular adaptation to different carnivore species. Molecular Ecology 26: 2111-2130. [Abstract]
  4. Friedrich S, Brunner E, Pauly M (2017) Permuting longitudinal data despite of the dependencies. Journal of Multivariate Analysis 153: 255-265. [Abstract]
  5. Brunner E, Konietschke F, Pauly M, Puri ML (2017) Rank-Based Procedures in Factorial Designs: Hypotheses about Nonparametric Treatment Effects. Journal of the Royal Statistical Society Series B 79: 1463–1485. [Abstract]
  6. Brockmeyer P, Kling A, Schulz X, Perske C, Schliephake H, Hemmerlein B. (2017) High mast cell density indicates a longer overall survival in oral squamous cell carcinoma. Scientific Reports 7: 14677. [Open Access]
  7. Pabel SO, Pabel AK, Schmickler J, Schulz X, Wiegand A. (2017) Impact of a Differential Learning Approach on Practical Exam Performance: A Controlled Study in a Preclinical Dental Course. Journal of Dental Education 81: 1108-1113. [Full text]
  8. Rödig T, Müller C, Hoch M, Haupt F, Schulz X, Wiegand A, Rizk M. (2017) Moisture content of root canal dentine affects detection of microcracks using micro-computed tomography. International Endodontic Journal 51: 357-363. [Abstract]
  9. Braulke F, Schulz X, Germing U, Schuler E, Platzbecker U, Nolte F, Hofmann WK, Giagounidis A, Götze K, Lübbert M, Schlenk RF, Schanz J, Bacher U, Ganser A, Büsche G, Letsch A, Schafhausen P, Bug G, Brümmendorf TH, Haas R, Trümper L, Shirneshan K, Haase D (2017) Peripheral blood cytogenetics allows treatment monitoring and early identificaiton of treatment failure to lenalidomide in MDS patients: results of the LE-MON-5 trial. Annals of Hematology 96: 887-894. [Abstract]
  10. Auer F, Hammoud Z, Ishkin A, Pratt D, Ideker T, Kramer F. (2017) ndexr - an R package to interface with the Network Data Exchange. Bioinformatics 34: 716-717. [Abstract]
  11. Bergau L, Tichelbäcker T, Kessel B, Lüthje L, Fischer TH, Friede T, Zabel M (2017) Predictors of mortality and ICD shock therapy in primary prophylactic ICD patients - A systematic review and meta-analysis. PLOS ONE 12(10): e0186387. [Open Access].
  12. Bramlage CP, Wallbach M, Ellenberger D, Deutsch C, Minguet J, Smith KH, Stock J, Goninski A, Bramlage P, Koziolek M, Mueller GA (2017). Variables to Predict Nephrological Disease in General, and Glomerulonephritis in Particular, in Patients with Microhematuria. Journal of Clinical Medicine Research 9: 560. [Full text]
  13. Huppke P, Huppke B, Ellenberger D, Rostasy K, Hummel H, Stark W, Brück W, Gärtner J. (2017) Therapy of highly active pediatric multiple sclerosis. Multiple Sclerosis Journal 25: 72-80. [Abstract]
  14. Linke F, Harenberg M, Nietert MM, Zaunig S, von Bonin F, Arlt A, Szczepanowski M, Weich HA, Lutz S, Dullin C, Janovská P, Krafcíková M, Trantírek L, Ovesná P, Klapper W, Beissbarth T, Alves F, Bryja V, Trümper L, Wilting J, Kube D (2017) Microenvironmental interactions between endothelial and lymphoma cells—a role for the canonical WNT pathway in Hodgkin lymphoma. Leukemia 31: 361-372. [Abstract]
  15. Linke F, Zaunig S, Nietert MM, von Bonin F, Lutz S, Dullin C, Janovská P, Beissbarth T, Alves F, Klapper W, Bryja V, Pukrop V , Trümper L, Wilting J, Kube D (2017) WNT5A: a motility-promoting factor in Hodgkin lymphoma. Oncogene 36: 13-23. [Abstract]
  16. Rühlmann F, Nietert M, Sprenger T, Wolff HA, Homayounfar K, Middel P, Bohnenberger H, Beissbarth T, Ghadimi BM, Liersch T, Conradi LC (2017) The Prognostic Value of Tyrosine Kinase SRC Expression in Locally Advanced Rectal Cancer. Journal of Cancer 8: 1229-1237. [Open Access]
  17. Lowes M, Kleiss M, Lueck R, Detken S, Koenig A, Nietert M, Beissbarth T, Stanek K, Langer C, Ghadimi M, Conradi LC, Homayounfar K. (2017) The utilization of multidisciplinary tumor boards (MDT) in clinical routine: results of a health care research study focusing on patients with metastasized colorectal cancer. International journal of colorectal disease 32: 1463-1469. [Full text]
  18. Büntzel J, Straube C, Heinz J, Röver C, Beham A, Emmert A, Hinterthaner M, Danner BC, Emmert A (2017) Thymectomy via open surgery or robotic video assisted thoracic surgery: Can a recommendation already be made? Medicine 96: e7161. [Open Access] 
  19. Emmert A, Straube C, Büntzel J, Röver C (2017) Robotic versus thoracoscopic lung resection: A systematic review and meta-analysis. Medicine 96: e7633. [Open Access]
  20. Büntzel J, Heinz J, Hinterthaner M, Schöndube FA, Straube C, Röver C, Emmert A. (2017) Robotic versus thoracoscopic thymectomy: The current evidence. The International Journal of Medical Robotics and Computer Assisted Surgery 13: e1847. [Abstract]
  21. Czerner CP, Winther HB, Zapf A, Wacker F, Vogel-Claussen J (2017) Breath-hold and free-breathing 2D phase-contrast MRI for quantification of oxygen-induced changes of pulmonary circulation dynamics in healthy volunteers. J Magn Reson Imaging 46:1698-1706. [Abstract] 
  22. Wienbeck S, Uhlig J, Luftner-Nagel S, Zapf A, Surov A, von Fintel E, Stahnke V, Lotz J, Fischer U (2017) The role of cone-beam breast-CT for breast cancer detection relative to breast density. European Radiology, 27: 5185-5195. [Abstract]
  23. Weber-Krüger M, Lutz C, Zapf A, Stahrenberg R, Seegers J, Witzenhausen J, Wasser K, Hasenfuß G, Gröschel K, Wachter R (2017) Relevance of supraventricular runs detected after cerebral ischemia. Neurology, 89: 1545-1552. [Abstract]
  24. Psychogios MN, Behme D, Schregel K, Tsogkas I, Maier IL, Leyhe JR, Zapf A, Tran J, Bähr M, Liman J, Knauth M (2017) One-Stop Management of Acute Stroke Patients: Minimizing Door-to-Reperfusion Times. Stroke 48: 3152-3155. [Full text]
  25. Pickenbrock H, Ludwig VU, Zapf A (2017) Support pressure distribution for positioning in neutral versus conventional positioning in the prevention of decubitus ulcers: a pilot study in healthy participants. BMC Nursing 16: 60. [Open Access]
  26. Balcarek P, Rehn S, Howells NR, Eldridge JD, Kita K, Dejour D, Nelitz M, Harden M, Friede T (2017) Results of Trochleoplasty versus Medial Patellofemoral Ligament Reconstruction in Patellar Instability caused by severe Trochlear Dysplasia - A Systematic Review and Meta-Analysis. Knee Surgery, Sports Traumatology, Arthroscopy 25: 3869-3877. [Abstract]
  27. Gross O, Kashtan CE, Rheault M, Flinter F, Savige J, Miner JH, Torra R, Ars E, Deltas C, Savva I, Perin L, Renieri A, Ariani F, Mari F, Baigent C, Judge P, Knebelman B, Heidet L, Lagas S, Blatt D, Ding J, Zhang Y, Gale1 DP, Prunotto M, Xue Y, Schachter AD, Morton LCG, Blem J, Huang M, Liu S, Vallee S, Renault D, Schifter J, Skelding J, Gear S, Friede T, Turner AN, Lennon R (2017) Advances and Unmet Needs in Genetics, Basic and Clinical Science in Alport syndrome: Report from the 2015 International Workshop on Alport Syndrome. Nephrology Dialysis Transplantation 32: 916-924. [Open Access]
  28. Gold SM, Enck P, Hasselmann H, Friede T, Hegerl U, Mohr DC, Otto C (2017) Control conditions for randomized trials of behavioral interventions in psychiatry: A decision framework. Lancet Psychiatry 4: 725–732. [Abstract]
  29. Wandel S, Neuenschwander B, Röver C, Friede T (2017) Using phase II data for the analysis of phase III studies: an application in rare diseases. Clinical Trials 14: 277-285. [Open Access]
  30. Nadoskar A, Raffel J, Scalfari AS, Friede T, Nicholas RS (2017) Pharmacological approaches to the management of secondary progressive multiple sclerosis. Drugs 77: 885-910. [Abstract] 
  31. Filippatos GS, de Graeff P, Bax JJ, Borg JJ, Cleland JGF, Dargie HJ, Flather M, Ford I, Friede T, Greenberg B, Henon-Goburdhun C, Holcomb R, Horst B, Lekakis J, Mueller‑Velten G, Papavassiliou AG, Prasad K, Rosano GMC, Severin T, Sherman W, Gattis Stough W, Swedberg K, Tavazzi L, Tousoulis D, Vardas P, Ruschitzka F, Anker SD (2017) Independent Academic Data Monitoring Committees for Clinical Trials in Cardiovascular and Cardiometabolic Diseases. European Heart Failure Journal 19: 449–456. [Full text]
  32. Bültmann E, Mußgnug HJ, Zapf A, Hartmann H, Nägele T, Lanfermann H (2017) Changes in brain microstructure during infancy and childhood using clinical feasible ADC-maps. Child's Nervous System 33: 735-745. [Abstract] 
  33. Wienbeck S, Nowak C, Zapf A, Stamm G, Unterberg-Buchwald C, Lotz J, Fischer U (2017) Artifacts Caused by Breast Tissue Markers in a Dedicated Cone-beam Breast CT in Comparison to Full-field Digital Mammography. Academic Radiology 24: 908-915. [Abstract] 
  34. Mütze T, Friede T (2017). Blinded sample size re-estimation in three-arm trials with 'gold standard' design . Statistics in Medicine 36: 3636–3653. [Abstract]
  35. Stellmann JP, Krumbholz M, Friede T, Gahlen A, Borisow N, Fischer K, Hellwig, Pache F, Ruprecht K, Havla J, Kümpfel T, Aktas O, Hartung HP, Ringelstein M, Geis C, Kleinschnitz C, Berthele A, Hemmer B, Angstwurm K, Young KL, Schuster S, Stangel M, Lauda F, Tumani H, Mayer C, Zeltner L, Ziemann U, Linker RA, Schwab M, Marziniak M, Then Bergh F, Hofstadt-van Oy U, Neuhaus O, Zettl U, Faiss J, Wildemann B, Paul F, Jarius S, Trebst C, Kleiter I on behalf of NEMOS (Neuromyelitis Optica Study Group) (2017) Immunotherapies in neuromyelitis optica spectrum disorder: Efficacy and predictors of response. Journal of Neurology, Neurosurgery and Psychiatry 88: 639-647. [Open Access]
  36. Raffel J, Wallace A, Gveric D, Reynolds R, Friede T, Nicholas R (2017) Patient-reported outcomes and survival in multiple sclerosis: a 10-year retrospective cohort study using the MSIS-29. PLOS Medicine 14: e1002346 [Open Access]
  37. Friede T, Röver C, Wandel S, Neuenschwander B (2017) Meta-analysis of two studies in the presence of heterogeneity with applications in rare diseases. Biometrical Journal 59: 658–671. [Open Access]
  38. Bocuk D, Wolff A, Krause P, Salinas G, Bleckmann A, Hackl C, et al. (2017) The adaptation of colorectal cancer cells when forming metastases in the liver: expression of associated genes and pathways in a mouse model. BMC Cancer 17: 342. [Open Access]
  39. Wlochowitz D, Haubrock M, Arackal J, Bleckmann A, Wolff A, Beißbarth T, Wingender E, Gültas M (2017) Computational Identification of Key Regulators in Two Different Colorectal Cancer Cell Lines. Frontiers in Genetics 7: 42. [Open Access]
  40. Bayerlová M, Menck K, Klemm F, Wolff A, Pukrop T, Binder C, Beißbart T, Bleckmann A, (2017) Ror2 Signaling and Its Relevance in Breast Cancer Progression. Frontiers in Oncology 7: 135. [Open Access]
  41. Schmidli H, Neuenschwander B, Friede T (2017) Meta-analytic-predictive use of historical variance data for the design and analysis of clinical trials. Computational Statistics & Data Analysis 113: 100-110. [Abstract]
  42. Schütz E, Fischer A, Beck J, Harden M, Koch M, Wuensch T, Stockmann M, Nashan B, Kollmar O, Matthaei J, Kanzow P, Walson PD, Brockmöller J, Oellerich M (2017) Graft-derived cell-free DNA, a noninvasive early rejection and graft damage marker in liver transplantation: A prospective, observational, multicenter cohort study. PLoS Medicine 14: e1002286. [Open Access]
  43. Messroghli DR, Pickardt T, Fischer M, Opgen-Rhein B, Papakostas K, Böcker D, Jakob A, Khalil M, Mueller GC, Schmidt F, Kaestner M, Udink ten Cate FEA, Wagner R, Ruf B, Kiski D, Wiegand G, Franziska Degener F, Bauer UMM, Friede T, Schubert S on behalf of the MYKKE consortium (2017) Towards evidence-based diagnosis and therapy of myocarditis in children and adolescents: Rationale, design, and first baseline data of MYKKE, a multi-centre registry and study platform. The American Heart Journal 187: 133-144. [Abstract]
  44. Seegers J, Hnatkova K, Friede T, Malik M, Zabel M (2017) T-wave loop area from a pre-implant 12-lead ECG is associated with appropriate ICD shocks. PLOS ONE 12(3): e0173868. [Open Access]
  45. Varges D, Manthey H, Heinemann U, Ponto C, Schmitz M, Krasnianski A, Breithaupt M, Fincke F, Kramer K, Friede T, Zerr I (2016) Doxycycline in early CJD – double-blinded randomized phase II and observational study. Journal of Neurology, Neurosurgery & Psychiatry 88: 119–125. [Open Access]
  46. Ursino M, Zohar S, Lentz F, Alberti C, Friede T, Stallard N, Comtes E (2017) Dose-finding methods using pharmacokinetics in small populations. Biometrical Journal 59: 804-825. [Open Access]
  47. Kunz CU, Stallard N, Parsons N, Todd S, Friede T (2016) Blinded versus unblinded estimation of a correlation coefficient to inform interim design adaptations. Biometrical Journal 2: 344–357. [Open Access]
  48. Wegscheider K, Friede T (2017) Do we consent to rules of consent and confidentiality? Biometrical Journal 2: 235–239. [Abstract]
  49. Friede T, Röver C, Wandel S, Neuenschwander B (2017) Meta-analysis of few small studies in orphan diseases. Research Synthesis Methods 8: 79–91. [Open Access]
  50. Röver C, Friede T (2017) Discrete approximation of a mixture distribution via restricted divergence. Journal of Computational and Graphical Statistics 26: 217-222. [Open Access] .
  51. Mütze T, Konietschke F, Munk A, Friede T (2017) A studentized permutation test for three-arm trials in the ‘gold standard’ design. Statistics in Medicine 36: 883–898. [Abstract] 
  52. Bodnar O, Link A, Arendacká B, Possolo A, Elster C (2017) Bayesian estimation in random effects meta-analysis using a non-informative prior. Statistics in Medicine 36: 378–399. [Abstract]
  53. Dango S, Beißbarth T, Weiss E, Seif Amir Hosseini A, Raddatz D, Ellenrieder V, Lotz J, Ghadimi BM, Beham A. (2017) Relevance of surgery in patients with non-variceal upper gastrointestinal bleeding. Langenbeck's Archives of Surgery 402: 509-519. [Abstract]



  1. Körner S, Böselt S, Wichmann K, Thau-Habermann N, Zapf A, Knippenberg S, Dengler R, Petri S (2016) The Axon Guidance Protein Semaphorin 3A Is Increased in the Motor Cortex of Patients With Amyotrophic Lateral Sclerosis. Journal of Neuropathology & Experimental Neurology 75: 326–333. [Full text]
  2. Jo P, Nietert M, Gusky L, Kitz J, Conradi LC, Müller-Dornieden A, Schüler P, Wolff HA, Rüschoff J, Ströbel P, Grade M, Liersch T, Beißbarth T, Ghadimi MB, Sax U, Gaedcke J. (2016) Neoadjuvant Therapy in Rectal Cancer - Biobanking of Preoperative Tumor Biopsies. Scientific reports 6: 35589.
  3. Friedrich S, Brunner E, Pauly M(2016) Permuting longitudinal data despite of the dependencies. Journal of Multivariate Analysis 153: 255-265. [Abstract]
  4. Sprenger T, Rothe H, Conradi LC, Beissbarth T, Kauffels A, Kitz J, Homayounfar K, Wolff H, Ströbel P, Ghadimi M, Wittekind C, Sauer R, Rödel C, Liersch T. (2016) Stage-Dependent Frequency of Lymph Node Metastases in Patients With Rectal Carcinoma After Preoperative Chemoradiation: Results from the CAO/ARO/AIO-94 Trial and From a Comparative Prospective Evaluation With Extensive Pathological Workup. Diseases of the Colon & Rectum 59: 377-85. [Abstract]
  5. Wlochowitz D, Haubrock M, Arackal J, Bleckmann A, Wolff A, Beißbarth T, Wingender E, Gültas M. (2016) Computational Identification of Key Regulators in Two Different Colorectal Cancer Cell Lines. Frontiers in Genetics 5: 42. [Abstract]
  6. Azizian A, Epping I, Kramer F, Jo P, Bernhardt M, Kitz J, Salinas G, Wolff HA, Grade M, Beißbarth T, Ghadimi BM, Gaedcke J. (2016) Prognostic Value of MicroRNAs in Preoperative Treated Rectal Cancer. International Journal of Molecular Sciences 15: 568. [Open access]
  7. Sprenger T, Rothe H, Beissbarth T, Conradi LC, Kauffels A, Homayounfar K, Behnes CL, Rödel C, Liersch T, Ghadimi M. (2016) Lymph node metastases in ypT1/2 rectal cancer after neoadjuvant chemoradiotherapy : The Achilles heel of organ-preserving operative procedures? Der Chirurg 87: 593-601. [Abstract]
  8. Kruppa J, Kramer F, Beißbarth T, Jung K (2016) A simulation framework for correlated count data of features subsets in high-throughput sequencing or proteomics experiments. Statistical Applications in Genetics and Molecular Biology 15:401-414. [Abstract]
  9. Sahlmann CO, Homayounfar K, Niessner M, Dyczkowski J, Conradi LC, Braulke F, Meller B, Beißbarth T, Ghadimi BM, Meller J, Goldenberg DM, Liersch T. (2016) Repeated adjuvant anti-CEA radioimmunotherapy after resection of colorectal liver metastases: Safety, feasibility, and long-term efficacy results of a prospective phase 2 study. Cancer 123: 638-649. [Abstract]
  10. Abbott BP, Röver C et al.(2016) Properties of the binary black hole merger GW150914. Physical Review Letters 116: 241102. [Open access]
  11. Abbott BP, Röver C et al. (2016) Improved analysis of GW150914 using a fully spin-precessing waveform model. Physical Review X 6: 041014. [Open access]
  12. Metz I, Beißbarth T, Ellenberger D, Pache F, Stork L, Ringelstein M, Aktas O, Jarius S, Wildemann BT, Dihazi H, Friede T, Brück W, Ruprecht K, Paul F (2016) Serum peptide reactivities may distinguish neuromyelitis optica subgroups and multiple sclerosis. Neurology: Neuroimmunology & Neuroinflammation 3: e204. [Open access]
  13. Schroeter MR, Köhler H, Wachter A, Bleckmann A, Hasenfuß G, Schillinger W (2016) Use of the Impella Device for Acute Coronary Syndrome Complicated by Cardiogenic Shock - Experience From a Single Heart Center With Analysis of Long-term Mortality. Journal of Invasive Cardiology 28: 467-472.
  14. Brockmeyer P, Krohn S, Thiemann C, Schulz X , Kauffmann P, Tröltzsch M, Schlottig F, Schliephake H, Gruber RM (2016) Primary stability and osseointegration of dental implants in polylactide modified bone - A pilot study in Goettingen minipigs. Journal of Cranio-Maxillofacial Surgery 44: 1095-1103. [Abstract]
  15. Herold S, Kumar P, Jung K, Graf I, Menkhoff H, Schulz X , Bähr M, Hein K (2016) CatWalk gait analysis in a rat model of multiple sclerosis. BMC Neuroscience 17: 78. [Abstract]
  16. Broekaert SM, Böer-Auer A, Kerl K, Herrgott I, Schulz X , Bonsmann G, Brehler R, Metze D (2016) Neutrophilic Epitheliotropism Is a Histapathological Clue to Neutrophilic Urticarial Dermatosis. The American Journal of Dermatopathology 38: 39-49. [Abstract]
  17. Karch A, Koch A, Zapf A, Zerr I, Karch A. (2016) Partial verification bias and incorporation bias affected accuracy estimates of diagnostic studies for biomarkers that were part of an existing composite gold standard. Journal of Clinical Epidemiology 78: 73-82. [Abstract]
  18. Förster J, Ahlenstiel-Grunow T, Zapf A, Mynarek M, Pape L (2016). Pubertal development in pediatric kidney transplant patients receiving mammalian target of Rapamycin inhibitors or conventional immunosuppression. Transplantation 100: 2461-2470. [Abstract]
  19. Straube S, Harden M, Schröder H, Arendacka B, Fan X, Moore A, Friede T (2016) Back schools for the treatment of chronic low back pain: possibility of benefit but no convincing evidence after 47 years of research – systematic review and meta-analysis. Pain 157: 2160–2172. [Open Access]
  20. Seegers J, Conen D, Jung K, Bergau L, Dorenkamp M, Munoz Exposito P, Lüthje L, Sohns C, Sossalla ST, Fischer TH, Hasenfuss G, Friede T, Zabel M (2016) Sex difference in appropriate shocks but not mortality during long-term follow-up in patients with implantable cardioverter-defibrillators. EP Europace 18: 1194–1202. [Open access]
  21. Olthoff A, Carstens PO, Zhang S, von Fintel E, Friede T, Lotz J, Frahm J, Schmidt J (2016) Evaluation of dysphagia by novel real-time magnetic resonance imaging. Neurology 87: 2132-2138. [Abstract]
  22. Patel S, Hee SW, Mistry D, Jordan J, Brown S, Dritsaki M, Ellard DR, Friede T, Lamb SE, Lord J, Madan J, Morris T, Stallard N, Colin Tysall, Adrian Willis, Underwood M and the Repository Group (2016) Identifying back pain subgroups: developing and applying approaches using individual patient data collected within clinical trials. Programme Grants for Applied Research 4 (10). [Open Access]
  23. Conen D, Arendacka B, Röver C, Bergau L, Munoz P, Wijers S, Sticherling C, Zabel M, Friede T (2016) Gender differences in appropriate shocks and mortality among patients with primary prophylactic implantable cardioverter-defibrillators: Systematic review and meta-analysis. PLoS ONE 11: e0162756. [Open access]
  24. Zapf A, Castell S, Morawietz L, Karch A (2016) Measuring inter-rater reliability for nominal data - which coefficients and confidence intervals are appropriate? BMC Medical Research Methodology 5:93. [Open access]
  25. Jackson N, Atar D, Maria Borentain M, Breithardt G, van Eickels M, Endres M, Fraass U, Friede T, Hannachi H, Janmohamed S, Kreuzer J, Landray M, Lautsch D, Le Floch C, Moll P, Naci1 H, Samani1 NJ, Svensson A, Thorstensen C, Tijssen J, Vandzhura V, Zalewski A, Kirchhof P (2016) Improving clinical trials for cardiovascular diseases: a position paper from the Cardiovascular Round Table of the European Society of Cardiology. European Heart Journal 37: 747-54. [Abstract]
  26. Ellenberger D, Friede T (2016) An unconditional test for change point detection in binary sequences with applications to clinical registries. Methods of Information in Medicine 55: 367–372. [Abstract]
  27. Nicotra A, Claus Newman C, Eremin O, Friede T, Malik O, Nicholas R 2016) Peripheral nerve dysfunction in middle-aged subjects born with thalidomide embryopathy. PLoS ONE 11: e0152902. [Open Access]
  28. Seegers J, Bergau L, Muñoz Expósito P, Bauer A, Fischer T, Lüthje L, Hasenfuß G, Friede T, Zabel M (2016) Prediction of appropriate shocks using 24-hour holter variables and T-wave alternans following first implantable cardioverter-defibrillator implantation in patients with ischemic and non-ischemic cardiomyopathy. American Journal of Cardiology 118: 86-94. [Open Access]
  29. Sudlow R, Branson J, Friede T, Morgan D, Whately-Smith C (2016) EFSPI/PSI Working Group on Data Sharing: Accessing and Working with Pharmaceutical Clinical Trial Patient Level Datasets – a Primer for Academic Researchers. BMC Medical Research Methodology 16 (Suppl 1): 73. [Open Access]
  30. Chataway J, Friede T (2016) The N-MOmentum trial: building momentum to advance trial methodology in a rare disease. Multiple Sclerosis Journal 22: 852–853. [Abstract]
  31. Mollenhauer B, Zimmermann J, Sixel-Döring F, Focke NK, Wicke T, Ebentheuer J, Schaumburg M, Lang E, Trautmann E, Zetterberg H, Taylor P, Friede T, Trenkwalder C & the DeNoPa Study Group (2016) Monitoring of thirty marker candidates in early Parkinson’s disease as progression markers. Neurology 87: 168-77. [Abstract]
  32. Sterz C, Ellenberger D, Meissner H, Friede T, Flachenecker P (2016) Employment-associated factors in multiple sclerosis – results of a cross sectional study in Germany. Edorium Journal of Disability and Rehabilitation 2: 24–33. [Open Access]
  33. Latif AHM, Brunner E (2016) A genetic Algorithm for designing microarray experiments. Computational Statistics 31: 409-424. [Abstract]
  34. Rave-Fränk M, Tehrany N, Kitz J, Leu M, Weber HE, Burfeind P, Schliephake H, Canis M, Beissbarth T, Reichardt HM, Wolff HA (2016) Prognostic value of CXCL12 and CXCR4 in inoperable head and neck squamous cell carcinoma. Strahlentherapie und Onkologie 192: 47-54. [Abstract]
  35. Tomas-Roig J, Piscitelli F, Gil V, Del Río JA, Moore TP, Agbemenyah H, Salinas-Riester G, Pommerenke C, Lorenzen S, Beißbarth T, Hoyer-Fender S, Di Marzo V, Havemann-Reinecke U (2016) Social defeat leads to changes in the endocannabinoid system: An overexpression of calreticulin and motor impairment in mice. Behavioural Brain Research 303: 34-43. [Abstract]
  36. Bleckmann A, Conradi LC, Menck K, Schmick NA, Schubert A, Rietkötter E, Arackal J, Middel P, Schambony A, Liersch T, Homayounfar K, Beißbarth T, Klemm F, Binder C, Pukrop T (2016) Beta-catenin-independent WNT signaling and Ki67 in contrast to the estrogen receptor status are prognostic and associated with poor prognosis in breast cancer liver metastases. Clinical & Experimental Metastasis 33: 309-23. [Abstract]
  37. Wachter A and Beißbarth T (2016) Decoding Cellular Dynamics in Epidermal Growth Factor Signaling Using a New Pathway-Based Integration Approach for Proteomics and Transcriptomics Data. Frontiers Genetics 6: 351. [Abstract]
  38. Pickenbrock H, Diel A, Zapf A (2016) A comparison between the Static Balance Test and the Berg Balance Scale: Validity, reliability, and comparative resource use. Clinical rehabilitation 30: 288-293.
  39. Unkel S, Röver C, Stallard N, Benda N, Posch M, Zohar S, Friede T (2016) Systematic reviews in paediatric multiple sclerosis and Creutzfeldt-Jakob disease exemplify shortcomings in methods used to evaluate therapies in rare conditions. Orphanet Journal of Rare Diseases 11: 16. [Open Access]
  40. Mütze T, Munk A, Friede T (2016) Design and analysis of three-arm trials with negative binomially distributed endpoints. Statistics in Medicine 35: 505–521. [Abstract]
  41. Unkel, S., Belka, C. and Lauber, K. (2016) On the analysis of clonogenic survival data: Statistical alternatives to the linear-quadratic model, Radiation Oncology, 11: 11. [Open Access]
  42. Ondra T, Dmitrienko A, Friede T, Graf A, Miller F, Stallard N, Posch M (2016) Methods for identification and confirmation of targeted subgroups in clinical trials: A systematic review. Journal of Biopharmaceutical Statistics 26: 99-119. [Open Access]
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  1. Pauly M, Ellenberger D, Brunner E (2015) Analysis of High-Dimensional One Group Repeated Measures Designs . Statistics 49: 1243–1261. [Abstract]
  2. Dressler D, Karapantzou C, Rohrbach S, Schneider S, Laskawi R (2015) Frontalis suspension surgery to treat patients with blepharospasm and eyelid opening apraxia: long-term results . Journal of Neural Transmission 124: 253-257. [Abstract]
  3. Helms HJ, Benda N, Friede T (2015) Point and interval estimators of the target dose in clinical dose-finding studies with active control. Journal of Biopharmaceutical Statistics 25: 939–957. [Open Access]
  4. Koschack J, Weibezahl L, Friede T, Himmel W, Makedonski P, Grabowski J (2015) Scientific versus experiential evidence: Discourse analysis of the CCSVI debate in a multiple sclerosis forum. Journal of Medical Internet Research 17: e159. [Open access]
  5. Kramer D, Schön M, Bayerlová M, Bleckmann A, Schön MP, Zörnig M, Dobbelstein M. (2015) A pro-apoptotic function of iASPP by stabilizing p300 and CBP through inhibition of BRMS1 E3 ubiquitin ligase activity. Cell Death Dis 12: e1634.
  6. Rietkötter E, Bleckmann A, Bayerlová M, Menck K, Chuang HN, Wenske B, Schwartz H, Erez N, Binder C, Hanisch UK, Pukrop T. (2015) Anti-CSF-1 treatment is effective to prevent carcinoma invasion induced by monocyte-derived cells but scarcely by microglia. Oncotarget 6: 15482-93.
  7. Bischoff A, Bayerlová M, Strotbek M, Schmid S, Beißbarth T, Olayioye MA (2015) A global microRNA screen identifies regulators of the ErbB receptor signaling network Cell Communication and Signaling 13: 5. [Abstract]
  8. Srinivas US, Dyczkowski J, Beißbarth T, Gaedcke J, Mansour WY, Borgmann K, Dobbelstein M. (2015) 5-Fluorouracil sensitizes colorectal tumor cells towards double stranded DNA breaks by interfering with homologous recombination repair. Oncotarget 6: 12574-86. [Abstract]
  9. Styczen H, Nagelmeier I, Beissbarth T, Nietert M, Homayounfar K, Sprenger T, Boczek U, Stanek K, Kitz J, Wolff HA, Ghadimi BM, Middel P, Liersch T, Rüschoff J, Conradi LC. (2015) HER-2 and HER-3 expression in liver metastases of patients with colorectal cancer. Oncotarget 6: 15065-76. [Abstract]
  10. Azizian A, Kramer F, Jo P, Wolff HA, Beißbarth T, Skarupke R, Bernhardt M, Grade M, Ghadimi BM, Gaedcke J. (2015) Preoperative Prediction of Lymph Node Status by Circulating Mir-18b and Mir-20a During Chemoradiotherapy in Patients with Rectal Cancer. World J Surg 39: 2329-35. [Abstract]
  11. Mansur A, Mulwande E, Steinau M, Bergmann I, Popov AF, Ghadimi M, Beissbarth T, Bauer M, Hinz J. (2015) Chronic kidney disease is associated with a higher 90-day mortality than other chronic medical conditions in patients with sepsis. Sci Rep. 5: 10539. [Abstract]
  12. Mansur A, Liese B, Steinau M, Ghadimi M, Bergmann I, Tzvetkov M, Popov AF, Beissbarth T, Bauer M, Hinz J. (2015) The CD14 rs2569190 TT Genotype Is Associated with an Improved 30-Day Survival in Patients with Sepsis: A Prospective Observational Cohort Study. PLoS One 10: e0127761. [Abstract]
  13. Becker K, Stauber M, Schwarz F, Beißbarth T. (2015) Automated 3D-2D registration of X-ray microcomputed tomography with histological sections for dental implants in bone using chamfer matching and simulated annealing. Comput Med Imaging Graph 44: 62-8. [Abstract]
  14. Mansur A, Steinau M, Popov AF, Ghadimi M, Beissbarth T, Bauer M, Hinz J. (2015) Impact of statin therapy on mortality in patients with sepsis-associated acute respiratory distress syndrome (ARDS) depends on ARDS severity: a prospective observational cohort study. BMC Med 13: 128. [Abstract]
  15. Mansur A, Steinau M, Popov AF, Milenovic S, Bireta C, Weymann A, Schotola H, Wiese CH, Beissbarth T, Tzvetkov M, Hinz J. (2015) Genetic Polymorphisms in Endothelin-1 as Predictors for Long-Term Survival and the Cardiac Index in Patients Undergoing On-Pump Cardiac Surgery. PLoS One 10: e0131155. [Abstract]
  16. Zhang X, Schulz R, Edmunds S, Krüger E, Markert E, Gaedcke J, Cormet-Boyaka E, Ghadimi M, Beissbarth T, Levine AJ, Moll UM, Dobbelstein M. (2015) MicroRNA-101 Suppresses Tumor Cell Proliferation by Acting as an Endogenous Proteasome Inhibitor via Targeting the Proteasome Assembly Factor POMP. Mol Cell 59: 243-57. [Abstract]
  17. Lüddecke S, Ertych N, Stenzinger A, Weichert W, Beissbarth T, Dyczkowski J, Gaedcke J, Valerius O, Braus GH, Kschischo M, Bastians H. (2015) The putative oncogene CEP72 inhibits the mitotic function of BRCA1 and induces chromosomal instability. Oncogene 35: 2398–2406. [Abstract]
  18. Bayerlová M, Jung K, Kramer F, Klemm F, Bleckmann A, Beißbarth T. (2015) Comparative study on gene set and pathway topology-based enrichment methods. BMC Bioinformatics 16: 334. [Abstract]
  19. Mansur A, Popov AF, Hanna AA, Bergmann I, Brandes IF, Beißbarth T, Bauer M, Hinz J. (2015) Perioperative Blood Glucose Levels?<150?mg/dL are Associated With Improved 5-Year Survival in Patients Undergoing On-Pump Cardiac Surgery: A Prospective, Observational Cohort Study. Medicine (Baltimore) 94: e2035. [Abstract]
  20. Bayerlova M, Klemm F, Kramer F, Pukrop T, Beißbarth , Bleckmann A. (2015) Newly Constructed Network Models of Different WNT Signaling Cascades Applied to Breast Cancer Expression Data. PLoS One 10: e0144014. [Abstract]
  21. Wu Y, Lee SH, Williamson EA, Reinert BL, Cho JH, Xia F, Jaiswal AS, Srinivasan G, Patel B, Brantley A, Zhou D, Shao L, Pathak R, Hauer-Jensen M, Singh S, Kong K, Wu X, Kim HS, Beißbarth T, Gaedcke J, Burma S, Nickoloff JA, Hromas RA. (2015) EEPD1 Rescues Stressed Replication Forks and Maintains Genome Stability by Promoting End Resection and Homologous Recombination Repair. PLoS Genet. 11: e1005675. [Abstract]
  22. von der Heyde S, Wagner S, Czerny A, Nietert M, Ludewig F, Salinas-Riester G, Arlt D, Beißbarth T. (2015) mRNA profiling reveals determinants of trastuzumab efficiency in HER2-positive breast cancer. Plos One 10: e0117818. [Abstract]
  23. Pickenbrock HM, Zapf A (equally contributed), Dressler D (2015) Effects of therapeutic positioning on vital parameters in patients with central neurological disorders: a randomised controlled trial. J Clin Nurs 24: 3681-3690.
  24. Sohns J, Schulte C, Zapf A, Unterberg-Buchwald C, Staab W, Kowallick J, Lauerer P, Nguyen T, Fasshauer M, Paul T, Lotz J, Steinmetz M (2015) Right atrial volume is increased in corrected Tetralogy of Fallot and correlates with the incidence of supraventricular arrhythmia - a CMR study. Pediatric Cardiology 36: 1239-47. [Abstract]
  25. Zapf A, Hoyer A, Kramer K, Kuss O (2015) Nonparametric meta-analysis for diagnostic accuracy studies. Statistics in Medicine 34: 3831-41. [Abstract]
  26. Wachter A, Beißbarth T (2015) pwOmics: An R package for pathway-based integration of time-series omics data using public database knowledge Bioinformatics 31: 3072-3074. [Abstract]
  27. Wachter A; Bernhardt S, Beissbarth T; Korf U (2015) Analysis of Reverse Phase Protein Array Data: From Experimental Design towards Targeted Biomarker Discovery. Microarrays 4: 520-539. [Abstract]
  28. Straube S, Werny B, Friede T (2015) A systematic review identifies shortcomings in the reporting of cross-over trials in chronic painful conditions. Journal of Clinical Epidemiology 68: 1496-1503. [Abstract]
  29. Röver C, Knapp G, Friede T (2015) Hartung-Knapp-Sidik-Jonkman approach andits modification for random-effects meta-analysis with few studies. BMC Medical Research Methodology, 15: 99. [Open Access]
  30. Brunkhorst LC, Fichtner A, Höcker B, Burmeister G, Ahlenstiel-Grunow T, Krupka K, Bald M, Zapf A, Tönshoff B, Pape L (2015) Efficacy and Safety of an Everolimus- vs. a Mycophenolate Mofetil-Based Regimen in Pediatric Renal Transplant Recipients. PLoS One 10: e0135439. [Abstract]
  31. Zapf A, Gwinner W (equally contributed), Karch A, Metzger J, Haller H, Koch A (2015) Non-invasive diagnosis of acute rejection in renal transplant patients using mass spectrometry of urine samples - a multicentre phase 3 diagnostic accuracy study. BMC Nephrol 16: 153. [Abstract]
  32. Kretschmer L, Bertsch HP, Zapf A, Mitteldorf C, Satzger I, Thoms KM, Völker B, Schön MP, Gutzmer R, Starz H (2015) Nodal Basin Recurrence After Sentinel Lymph Node Biopsy for Melanoma: A Retrospective Multicenter Study in 2653 Patients. Medicine (Baltimore) 94: e1433. [Abstract]
  33. Stallard N, Kunz CU, Todd S, Parsons N, Friede T (2015) Flexible selection of a single treatment incorporating short-term endpoint information in a phase II/III clinical trial. Statistics in Medicine 34: 3104-3115. [Open Access ]
  34. Schmidt C, Gerlach N, Schmitz M, Thom T, Kramer K, Friede T, Zerr I (2015) Baseline CSF/serum-ratio of apolipoprotein E and rate of differential decline in Alzheimer’s disease. Journal of Alzheimer’s Disease 48: 189–196. [Abstract]
  35. Röver C, Nicholas R, Straube S, Friede T (2015) Changing EDSS progression in placebo cohorts in relapsing MS: A systematic review and meta-regression. PLoS ONE 10: e0137052. [Open Access]
  36. Dugas M, Jöckel KH, Friede T, Gefeller O, Kieser M, Marschollek M, Ammenwerth E, R. Röhrig R, Knaup-Gregori P, Prokosch HU (2015) Memorandum “Open Metadata”: Open Access to documentation forms and item catalogs in healthcare. Methods of Information in Medicine 54: 376–378. [Abstract]
  37. Ernst A, Kapfhammer H, Anders H, Orth M, Hennel R, Seidl K, Winssinger N, Belka C, Unkel S, Lauber K (2015) HSP90 inhibition as a means of radiosensitizing resistant, aggressive soft tissue sarcomas. Cancer Letters 365: 211-222. [Abstract]
  38. Rommer PS, Buckow K, Ellenberger D, Friede T, Pitschnau-Michel D, Fuge J, Stüve O, Zettl UK for the German Multiple Sclerosis (MS) Registry of the German National MS Society (DMSG) (2015) Patients’ characteristics influencing the longitudinal utilization of steroids in multiple sclerosis – an observational study. European Journal of Clinical Investigation 45: 587-593. [Abstract]
  39. Körner S, Kollewe K, Abdulla S, Zapf A, Dengler R, Petri S (2015) Interaction of physical function, quality of life and depression in Amyotrophic lateral sclerosis: characterization of a large patient cohort. BMC Neurol 15: 84. [Open access]
  40. Zapf A, Brunner E, Konietschke F (2015) A Wild Bootstrap approach for the selection of biomarkers in early diagnostic trials. BMC Medical Research Methodology 15: 43. [Open access]
  41. Schröder M, Stüber V, Walendzik E, O'Loughlin PF, Zapf A, Krettek C, Gaulke R (2015). Establishing an optimal trajectory for calcaneotibial K-wire fixation in emergent treatment of unstable ankle fractures. Technology and Health Care 23: 215-21. [Abstract]
  42. Pauly M, Brunner E, Konietschke F (2015). Asymptotic Permutation Tests in General Factorial Designs. Journal of the Royal Statistical Society - Series B 77: 461–473. [Abstract]
  43. Pickenbrock H, Ludwig VU, Zapf A, Dressler D (2015). Conventional versus neutral positioning in central neurological disease: a multicenter randomized controlled trial. Deutsches Ärzteblatt International 112: 35-42. [Abstract]
  44. Stellmann JP, Stürner KH, Young KL, Siemonsen S, Friede T, Heesen C (2015) Regression to the mean and predictors of MRI disease activity in RRMS placebo cohorts - is there a place for baseline-to-treatment studies in MS? PLoS ONE 10: e0116559. [Open Access]
  45. Schmidt C, Gerlach N, Peter C, Gherib K, Lange K, Friede T, Zerr I (2015) CSF Apolipoprotein E Concentration and Progression of Alzheimer's Disease. Journal of Alzheimer’s Disease 43: 1229-1236. [Abstract]
  46. Kiessling J, Leifholz Unkel S, Pons-Kühnemann J, Thunberg C, Pedersen JN (2015) A Comparison of Conventional and In-Situ Audiometry on Participants with Varying Levels of Sensorineural Hearing Loss, Journal of the American Academy of Audiology 26: 68-79. [Abstract]
  47. Kunz CU, Friede T, Parsons N, Todd S, Stallard N (2015) A comparison of methods for treatment selection in seamless phase II /III clinical trials incorporating information on short-term endpoints. Journal of Biopharmaceutical Statistics 25: 170-189. [Open Access]
  48. Bleckmann A, Leha A, Artmann S, Menck K, Salinas-Riester G, Binder C, Pukrop T, Beißbarth T, Klemm F (2015) Integrated miRNA and mRNA profiling of tumor-educated macrophages identifies prognostic subgroups in estrogen receptor-positive breast cancer. Molecular Oncology 9: 155-66. [Open access]
  49. Tehrany N, Kitz J, Rave-Fränk M, Lorenzen S, Li L, Küffer S, Hess CF, Burfeind P, Reichardt HM, Canis M, Beißbarth T, Wolff HA (2015) High-grade acute organ toxicity and p16INK4A expression as positive prognostic factors in primary radio(chemo)therapy for patients with head and neck squamous cell carcinoma. Strahlentherapie und Onkologie 191: 566-72. [Abstract]
  50. Mansur A, Klee Y, Popov AF, Erlenwein J, Ghadimi M, Beißbarth T, Bauer M, Hinz J. (2015) Primary bacteraemia is associated with a higher mortality risk compared with pulmonary and intra-abdominal infections in patients with sepsis: a prospective observational cohort study. BMJ Open 5: e006616. [Open access]
  51. Helms HJ, Benda N, Zinserling J, Kneib T, Friede T (2015) Spline-based procedures for dose-finding studies with active control. Statistics in Medicine 34: 232-248. [Open Access]
  52. Knösel M, Nüser C, Jung K, Helms HJ, Engelke W, Sandoval P (2015) Interaction between deglutition, tongue posture, and malocclusion: A comparison of intra-oral compartment formation in subjects with neutral occlusion or different types of malocclusion. The Angle Orthodontist 86: 697-705.
  53. Brockmeyer P, Hemmerlein B, Jung K, Fialka F, Brodmann T, Gruber RM, Schliephake H, Kramer FJ (2015) Connexin subtype expression during oral carcinogenesis: A pilot study in patients with oral squamous cell carcinoma. Molecular and Clinical Oncology 4: 298-302. [Abstract]
  54. Haetscher N, Feuermann Y, Wingert S, Rehage M, Thalheimer FB, Weiser C, Bohnenberger H, Jung K, Schroeder T, Serve H, Oellerich T, Henninghausen L, Rieger MA (2015) STAT5-regulated microRNA-193b controls haematopoietic stem and progenitor cell expansion by modulating cytokine receptor signalling. Nature Communications 6: 8928.
  55. Schmidt H, Djukic M, Jung K, Holzgraefe M, Dechent P, von Steinbuechel N, Blocher J, Eiffert H, Schmidt-Samoa C (2015) Neurocognitive functions and braun atrophy after proven neuroborreliosis: a case-control study. BMC Neurology 15: 139.
  56. Ganster C, Kämpfe D, Jung K, Shirneshan K, Braulke F, Machherndl-Spandl S, Suessner S, Bramlage CP, Legler TJ, Koziolek MJ, Haase D, Schanz J (2015) New data shed light on Y-loss related pathogenesis in MDS. Genes, Chromosomes and Cancer 54: 717-24.
  57. Knösel M, Fendel C, Jung K, Sandoval P, Engelk WG (2015) Pre-surgical orthopedics by drink plates does not significantly improve deviating deglutition in infants with cleft lip and palate. Angle Orthodontist 86: 315-323. [Abstract]
  58. Wolf HA, Ihler F, Zeller N, Welz C, Jung K, Canis M, Steiner W (2015) (Chemo)radiotherapy after laser microsurgery and selective neck dissection for pN2 head and neck cancer. European Archives of Oto-Rhino-Laryngology 273: 1533-1541. [Abstract]



  1. Kastl L, Sauer S, Beißbarth T, Becker M, Krammer P, Gülow K. (2014) TNF-a stimulation enhances ROS-dependent cell migration via NF-?B activation in liver cells. Free Radic Biol Med 75 Suppl 1: S32. [Abstract]
  2. Engelke W, Glombek J, Psychogios S, Schneider S, Ellenberger D, Santander P. (2014) Displacement of oropharyngeal structures during suction-swallowing cycles. European Archives of Oto-Rhino-Laryngology 271: 1987-1997. [Abstract]
  3. Puls M, Tichelbäcker T, Bleckmann A, Hünlich M, von der Ehe K, Beuthner BE, Rüter K, Beißbarth T, Seipelt R, Schöndube F, Hasenfuß G, Schillinger W. (2014) Failure of acute procedural success predicts adverse outcome after percutaneous edge-to-edge mitral valve repair with MitraClip. EuroIntervention 9: 1407-17. [Abstract]
  4. Hohloch K, Bertram N, Trümper L, Beißbarth T, Griesinger F. (2014) Superior vena cava syndrome causedby a malignant tumor: a retrospective single-center analysis of 124 cases. J Cancer Res Clin Oncol 140: 2129-34. [Abstract]
  5. Mannil M, Solari A, Leha A, Pelayo-Negro AL, Berciano J, Schlotter-Weigel B, Walter MC, Rautenstrauss B, Schnizer TJ, Schenone A, Seeman P, Kadian C, Schreiber O, Angarita NG, Fabrizi GM, Gemignani F, Padua L, Santoro L, Quattrone A, Vita G, Calabrese D; CMT-TRIAAL/CMT-TRAUK Group, Young P, Laurà M, Haberlová J, Mazanec R, Paulus W, Beißbarth T, Shy ME, Reilly MM, Pareyson D, Sereda MW. (2014) Selected items from the Charcot-Marie-Tooth (CMT) Neuropathy Score and secondary clinical outcome measures serve as sensitive clinical markers of disease severity in CMT1A patients. Neuromuscul Disord 24: 1003-17. [Abstract]
  6. Puls M, Sobisiak B, Bleckmann A, Jacobshagen C, Danner BC, Hünlich M, Beißbarth T, Schöndube F, Hasenfuß G, Seipelt R, Schillinger W. (2014) Impact of frailty on short- and long-term morbidity and mortality after transcatheter aortic valve implantation: risk assessment by Katz Index of activities of daily living. EuroIntervention 10: 609-19. [Abstract]
  7. von der Heyde S, Sonntag J, Kaschek D, Bender C, Bues J, Wachter A, Timmer J, Korf U, Beißbarth T(2014) RPPanalyzer toolbox: an improved R package for analysis of reverse phase protein array data. Biotechniques 57: 125-35.
  8. Landmann H, Proia DA, He S, Ogawa LS, Kramer F, Beißbarth T, Grade M, Gaedcke J, Ghadimi M, Moll U, Dobbelstein M. (2014) UDP glucuronosyltransferase 1A expression levels determine the response of colorectal cancer cells to the heat shock protein 90 inhibitor ganetespib. Cell Death Dis 5: e1411. [Abstract]
  9. Gaedcke J, Leha A, Claus R, Weichenhan D, Jung K, Kitz J, Grade M, Wolff HA, Jo P, Doyen J, Gérard JP, Johnsen SA, Plass C, Beißbarth T, Ghadimi M. (2014) Identification of a DNA methylation signature to predict disease-free survival in locally advanced rectal cancer. Oncotarget 5: 8123-35. [Abstract]
  10. Oberhofer G, Grossmann D, Siemanowski JL, Beißbarth T, Bucher G. (2014) Wnt/ß-catenin signaling integrates patterning and metabolism of the insect growth zone. Development 141: 4740-50. [Abstract]
  11. Flachenecker P, Buckow K, Pugliatti M, Bašic Kes V, Battaglia MA, Boyko A, Ellenberger D, Eskic D, Ford D, Friede T, Fuge J, Glaser A, Hillert J, Holloway E, Ioannidou E, Kappos L for the EUReMS Consortium (2014) Multiple sclerosis registries in Europe – results of a systematic survey. Multiple Sclerosis Journal 20: 1523-1532. [Abstract]
  12. Crins ND, Röver C, Goralczyk AD, Friede T (2014) Interleukin-2 Receptor Antagonists for Pediatric Liver Transplant Recipients: A Systematic Review and Meta-Analysis of Controlled Studies. Pediatric Transplantation 18: 839-850. [Abstract]
  13. Schmidt C, Becker H, Peter C, Lange K, Friede T, Zerr I (2014) Plasma prion protein concentration and progression of Alzheimer's disease. Prion 8: 12-16. [Open access]
  14. Schmidt C, Wolff M, von Ahsen N, Lange K, Friede T, Zerr I (2014) CR1 is potentially associated with rate of decline in sporadic Alzheimer's disease. Journal of Clinical Neuroscience 21: 1705-1708. [Abstract]
  15. Vormfelde SV, Abed MA, Hua TD, Schneider S, Friede T, Chenot JF (2014) Schulung oral antikoagulierter Patienten zur Arzneimitteltherapiesicherheit - eine cluster-randomisierte Studie in Hausarztpraxen (Educating orally anticoagulated patients in drug safety – a cluster-randomized study in general practice). Deutsches Ärzteblatt 111: 607-614. [Open Access]
  16. Patel S, Ngunjiri A, Hee SW, Yang Y, Brown S, Friede T, Griffiths F, Lord J, Sandhu H, Thistlethwaite J, Tysall C, Underwood M (2014) Primum non nocere: Shared informed decision making in low back pain – A pilot cluster randomised trial. BMC Musculoskeletal Disorders 15: 282. [Open Access]
  17. Brockmeyer P, Lange K, Hahn W, Schliephake H, Matthias Gruber R (2014) Increase of homogenous new bone formation using osteoinductive factor rhGDF-5 during sinus floor augmentation in Goettingen Minipigs. Clinical Oral Implants Research 26: 1321–7. [Abstract]
  18. Rödiger M, Rinke S, Ehret-Kleinau F, Pohlmeyer F, Lange K, Bürgers R, Gersdorff N. (2014) Evaluation of removal forces of implant-supported zirconia copings depending on abutment geometry, luting agent and cleaning method during re-cementation. Journal of Advanced Prosthodontics 6: 233-40.
  19. Schmickler J, Wurbs S, Wurbs S, Lange K, Rinke S, Hornecker E, Mausberg RF, Ziebolz D. (2014) Influence of the utilization time of different manual toothbrushes on oral hygiene assessed during a 6-month observation period: a randomized clinical trial. Journal of Periodontology 85: 1050-8
  20. Gruber RM, Krohn S, Mauth C, Dard M, Molenberg A, Lange K, Perske C, Schliephake H. (2014) Mandibular reconstruction using a calcium phosphate/polyethylene glycol hydrogel carrier with BMP-2. Journal of Clinical Periodontology 41: 820-6.
  21. Herrmann-Lingen C, Brunner E, Hildenbrand S, Loew TH, Raupach T,Spies C, Treede RD, Vahl CF, Wenz HJ. (2014) Evaluation of medical researchperformance – position paper of the Association of the Scientific Medical Societies in Germany (AWMF). GMS German Medical Science 12: 11. [Open Access]
  22. Gutenberg A, Nischwitz MD, Gunawan B, Enders C, Jung K, Bergmann M, Feiden W, Egensperger R, Keyvani K, Stolke D, Sure U, Schroeder HWS, Warzok R, Schober R, Meixensberger J, Paulus W, Wassmann H, Stummer W, Blümcke I, Buchfelder M, van Landeghem FKH, Vajkoczy P, Günther M, Bedke J, Giese A, Rohde V, Brück W, Füzesi L, Sander B (2014) Predictive Chromosomal Clusters of Synchronous and Metachronous Brain Metastases in Clear Cell Renal Cell Carcinoma. Cancer Genetics 207: 206-213.
  23. Brockmeyer P, Jung K, Perske C, Schliephake H and Hemmerlein B (2014) Membrane connexin 43 acts as an independent prognostic marker in oral squamous cell carcinoma. International Journal of Oncology 45: 273-281.
  24. Rau TT, Agaimy A, Gehoff A, Geppert C, Jung K, Knobloch K, Langner C, Lugli A, Lurkin IG, Nagtegaal I, Rüschoff J, Saegert X, Sarbia M, Schneider-Stock R, Vieth M, Zwarthoff E, Hartmann A (2014) Defined morphological criteria allow reliable diagnosis of colorectal serrated polyps and predict polyp genetics. Virchows Archiv 464: 663-672.
  25. Mitteldorf C, Bertsch HP, Jung K, Thoms KM, Schön MP, Tronnier M andKretschmer L (2014) Sentinel Node Biopsy Improves Prognostic Stratification in Patients with Thin (pT1) Melanomas and an Additional Risk Factor. Annals of Surgical Oncology 21: 2252-2258.
  26. Vollmann D, Woronowicz S, Kmiec L, Jung K, Zenker D, Seegers J, Sossalla S, Dorenkamp M, Sohns C, Lüthje L, Hasenfuss G and Zabel M (2013) Lead Failure Rates and Patient Mortality during Long-Term Follow-Up of Passive Fixation Sprint Fidelis Lead. EP-Europace 16: 258-264.
  27. Wolf I, Friede T, Hallier E, Straube S (2014) Work-related outcomes in randomised placebo-controlled pain trials: a systematic review and meta-analysis. Journal of Occupational Medicine and Toxicology 9: 25. [Open Access]
  28. Kunz CU, Friede T, Parsons N, Todd S, Stallard N (2014) Data-driven treatment selection for seamless phase II/III trials incorporating early-outcome data. Pharmaceutical Statistics 13: 238–246. [Open Access]
  29. Von der Hyde S, Bender C, Henjes F, Sonntag J, Korf U, Beißbarth T. (2014) Boolean ErbB network reconstructions and perturbation simulations reveal individual drug response in different breast cancer cell lines. BMC Systems Biology 2014 8: 75. [Abstract]
  30. Mansur A, von Gruben L, Popov AF, Steinau M, Bergmann I, Ross D, Ghadimi M, Beißbarth T, Bauer M, Hinz J. (2014) The regulatory toll-like receptor 4 genetic polymorphism rs11536889 is associated with renal, coagulation and hepatic organ failure in sepsis patients. J Transl Med 12: 177. [Abstract]
  31. Von der Heyde S, Fromm-Dornieden C, Salinas-Riester G, Beißbarth T, Baumgartner B. (2014) Dynamics of mRNA and polysomal abundance in early 3T3-L1 adipogenesis. BMC Genomics 18: 381. [Abstract]
  32. Kramer F, Bayerlova M, Beißbarth T. (2014) R-based software for the integration of pathway data into bioinformatic algorithms. Biology (Basel), 3: 85-100, Review. [Abstract]
  33. Fokas E, Liersch T, Fietkau R, Hohenberger W, Beißbarth T, Hess C, Becker H, Ghadimi M, Mrak K, Merkel S, Raab HR, Sauer R, Wittekind C, Rödel C. (2014) Tumor regression grading after preoperative chemoradiotherapy for locally advanced rectal carcinoma revisited: Updated results of the CAO/ARO/AIO-94 trial after a median follow-up of 11 years. Journal of Clinical Oncology 32: 1554-62. [Abstract]
  34. Jung K, Dihazi H, Bibi A, Dihazi GH, Beißbarth T. (2014) Adaption of the global test idea to proteomics data with missing values. Bioinformatics 30: 1424-30. [Abstract]
  35. Chenot JF, Hua TD, Abu Abed M, Schneider-Rudt H, Friede T, Schneider S, Vormfelde SV (2014) Safety relevant knowledge of orally anticoagulated patients: a baseline survey in primary care. BMC Family Health: 15: 104. [Open Access]
  36. Patel S, Ngunjiri A, Sandhu H, Griffiths F, Thistlethwaite J, Brown S, Friede T, Lord J, Colin Tysall C, Woolvine M, Underwood M (2014) The design and development of a decision support package for low back pain. Arthritis Care & Research 66: 925-933. [Open Access]
  37. Golkowski D, Friede T, Kieser M (2014) Blinded sample size re-estimation in crossover bioequivalence trials. Pharmaceutical Statistics 13: 157–162. [Abstract]
  38. Pauly M, Brunner E, Konietschke F (2014) Asymptotic permutation tests in general factorialdesigns Royal Statistical Society 77: 461-473. [Abstract]
  39. K Müller, S Koster, J Painer, A Söderberg, D Gavier-Widèn, E Brunner, M Dehnhard, K Jewgenow (2014) Testosterone production and spermatogenesis in free-ranging Eurasian lynx (Lynx lynx) throughout the year. European Journal of Wildlife Research 60: 569-577. [Abstract]
  40. Satzger I, Meier A, Zapf A, Niebuhr M, Kapp A, Gutzmer R (2014). Is there a therapeutic benefit of complete lymph node dissection in melanoma patients with low tumor burden in the sentinel node? Melanoma Research 24: 454-461. [Abstract]
  41. Stallard N, Homburg T, Parsons N, Friede T (2014) Adaptive designs for confirmatory clinical trials with subgroup selection. Journal of Biopharmaceutical Statistics 24: 168-187. [Abstract]
  42. Kastl L, Sauer SW, Ruppert T, Beißbarth T, Becker MS, Süss D, Krammer PH, Gülow K. (2014) TNF-α mediates mitochondrial uncoupling and enhances ROS-dependent cell migration via NF-κB activation in liver cells. FEBS Lett 588: 175-83. [Abstract]
  43. Mansur A, Hinz J, Hillebrecht B, Bergmann I, Popov AF, Ghadimi M, Bauer M, Beißbarth T, Mihm S. (2014) Ninety-day survival rate of patients with sepsis relates to programmed cell death 1 genetic polymorphism rs11568821. J Investig Med 62: 638-43. [Abstract]
  44. Kottas M, Kuss O, Zapf A (2014) A modified Wald interval for the area under the ROC curve (AUC) in diagnostic case-control studies. BMC Medical Research Methodology 14: 26. [Abstract]
  45. Chenot JF, Weber P, Friede T (2014) Efficacy of Ambroxol lozenges for sore throat: a meta-analysis. BMC Family Practice 15: 45. [Open Access]
  46. Huppke B, Ellenberger D, Rosewich H, Friede T, Gärtner J, Huppke P (2014) Clinical presentation of pediatric multiple sclerosis before puberty. European Journal of Neurology 2: 441-446. [Abstract]
  47. Dugas M, Jöckel KH, Gefeller O, Knaup-Gregori P, Friede T, Ammenwerth E, Kieser M, Prokosch HU (2014) Freier Zugang zu Dokumentationsformularen und Merkmalskatalogen im Gesundheitswesen. Memorandum „Open Metadata“. GMS Med Inform Biom Epidemiol. 10: 1. [Open Access]
  48. Hackmann A, Wu H, Schneider UM, Meyer K, Jung K and Krebber H (2014)Quality control of spliced mRNAs requires the shuttling SR proteins Gbp2 and Hrb1. Nature Communications 5: 3123. [Abstract]
  49. Sudau F, Friede T, Grabowski J, Koschack J, Makedonski P, Himmel W (2014) Sources of Information and Behavioral Patterns in Health Online Forums: Observational Study. J Med Internet Res 16: e10. [Open Access]
  50. Rinke S, Roediger M, Eickholz P, Lange K, Ziebolz D. (2014) Technical and biological complications of single-molar implant restorations. Clinical Oral Implants Research 26: 1024-1030.



  1. Chuang HN, van Rossum D, Sieger D, Siam L, Klemm F, Bleckmann A, Bayerlová M, Farhat K, Scheffel J, Schulz M, Dehghani F, Stadelmann C, Hanisch UK, Binder C, Pukrop T. (2013) Carcinoma cells misuse the host tissue damage response to invade the brain. Glia 61: 1331-46.
  2. Behm T, Horowski A, Schneider S, Bock HC, Mielke D, Rohde V, StockhammerF. (2013) Concomitant and adjuvant temozolomide of newly diagnosed glioblastomain elderly patients. Clinical Neurology and Neurosurgery 115: 2142-6. [Abstract]
  3. Behnes CL, Bedke J, Schneider S, Küffer S, Strauss A, Bremmer F, Ströbel P, Radzun HJ. (2013) Myoglobin expression in renal cell carcinoma is regulated by hypoxia. Experimental and Molecular Pathology 95: 307-312. [Abstract]
  4. Laskawi R, Niemczewska A, Schneider S, Winterhoff J, Beutner C, Rohrbach S. (2013) Änderung von Dosis und Injektionsmuster der Botulinumtoxin-Langzeittherapie fazialer Dyskinesien/ Changes in the dosage and injection pattern in the long-term treatment of facial dyskinesis with botulinum toxin. Laryngo-Rhino-Otologie 93: 186-192. [Abstract]
  5. Nagy GCs, Wunsch M, Jordan A, Lange K (2013) Antegrade Eversion Endarterectomy of the External Iliac Artery. European Journal of Vascular and Endovascular Surgery 46: 103-109. [Abstract]
  6. Schiekirka S, Reinhardt D, Beißbarth T, Anders S, Pukrop T, Raupach T. (2013) Estimating learning outcomes from pre- and posttest student self-assessments: a longitudinal study. Acad Med 88: 369-75. [Abstract]
  7. Wolff HA, Conradi LC, Beißbarth T, Leha A, Hohenberger W, Merkel S, Fietkau R, Raab HR, Tschmelitsch J, Hess CF, Becker H, Wittekind C, Sauer R, Rödel C, Liersch T; German Rectal Cancer Study Group. (2013) Gender affects acute organ toxicity during radiochemotherapy for rectal cancer: long-term results of the German CAO/ARO/AIO-94 phase III trial. Radiother Oncol 108: 48-54. [Abstract]
  8. Sprenger T, Rothe H, Becker H, Beissbarth T, Homayounfar K, Gauss K, Kitz J, Wolff H, Scheel AH, Ghadimi M, Rödel C, Conradi LC, Liersch T. (2013) Lymph node metastases in rectal cancer after preoperative radiochemotherapy: impact of intramesorectal distribution and residual micrometastatic involvement. Am J Surg Pathol 37:1283-9. [Abstract]
  9. Fokas E, Conradi L, Weiss C, Sprenger T, Middel P, Rau T, Dellas K, Kitz J, Rödel F, Sauer R, Rüschoff J, Beißbarth T, Arnold D, Ghadimi BM, Rödel C, Liersch T. (2013)Preoperative chemoradiation therapy with capecitabine/oxaliplatin and cetuximab in rectal cancer: long-term results of a prospective phase 1/2 study. Int J Radiat Oncol Biol Phys 87: 992-999. [Abstract]
  10. Camps J, Pitt JJ, Emons G, Hummon AB, Case CM, Grade M, Jones TL, Nguyen QT, Ghadimi BM, Beißbarth T, Difilippantonio MJ, Caplen NJ, Ried T (2013) Genetic amplication of the NOTCH modulator LNX2 upregulates the WNT/ß-catenin pathway in colorectal cancer Cancer Res 73: 2003-2013. [Abstract]
  11. Kramer F, Bayerlová M, Klemm F, Bleckmann A, Beißbarth T. (2013) rBiopaxParser--an R package to parse, modify and visualize BioPAX data. Bioinformatics 29: 520-5222. [Abstract]
  12. Brunner, E., Puri ML (2013). Comments on the paper ‘Type I error and test power of different tests for testing interaction effects in factorial experiments’ by M. Mendes and S. Yigit (Statistica Neerlandica, 2013, pp. 1–26). Statistica Neerlandica 67: 390-396. [Abstract]
  13. Balcarek P, Terwey A, Jung K, Wald T A, Frosch S, Schüttrunpf J P, Wachowski M M, Dathe H and Stürmer K M (2013) Influence of tibial slope asymmetry on femoral rotation in patients with lateral patellar instability. Knee Surgery, Sports Traumatology, Athroscopy 9: 2155-2163. [Abstract]
  14. Psychogios MK, Schramm P, Frölich AM, Kallenberg K, Wasser K, Reinhardt L, Kreusch A, Jung K, Knauth M (2013): Alberta Stroke Program Early CT Scale Evaluation of Multimodal Computed Tomography in Predicting Clinical Outcomes of Stroke Patients Treated With Aspiration Thrombectomy. Stroke 44: 2188-2193. [Abstract]
  15. Braulke F, Jung K, Schanz J, Götze K, Müller-Thomas C, Platzbecker U, Germing U, Brümmendorf TH, Bug G, Ottmann O, Giagounidis AAN, Stadler M, Hofmann W-K, Schafhausen P, Lübbert M, Schlenk RF, Blau IW, Ganster C, Pfeiffer S, Shirneshan K, Metz M, Detken S, Seraphin J, Jentsch-Ullrich K, Böhme A, Schmidt B, Trümper L, Haase D (2013) Molecular cytogenetic monitoring from CD34+ peripheral blood cells in myelodysplastic syndromes - First results from a prospective multicenter German diagnostic study. Leukemia Research 37: 900-906. [Abstract]
  16. Kruss S, Erpenbeck L, Amschler K, Mundinger TA, Böhm H, Helms HJ, Friede T, Andrews RK, Schön MP, Spatz JP (2013) Adhesion Maturation of neutrophils on nanoscopically presented platelet glycoprotein Ibα. ACS Nano 7: 9984-9996. [Abstract]
  17. Schneider S, Schmidli H, Friede T (2013) Blinded sample size reestimation for recurrent event data with time trends. Statistics in Medicine 32: 5448–5457. [Abstract]
  18. Mollenhauer B, Trautmann E, Sixel-Döring F, Wicke T, Ebentheuer J, Schaumburg M, Lang E, Focke NK, Kumar K, Lohmann K, Klein C, Schlossmacher M, Kohnen R, Friede T, Trenkwalder C (2013) Non-motor and diagnostic findings in de novo Parkinson’s disease subjects of the DeNoPa cohort. Neurology 81: 1226–1234. [Abstract]
  19. Steinvorth SM, Röver C, Schneider S, Nicholas R, Straube S, Friede T (2013) Explaining temporal trends in annualized relapse rates in placebo groups of randomized controlled trials in relapsing multiple sclerosis: Systematic review and meta-regression. Multiple Sclerosis Journal 19: 1580-1586. [Abstract]
  20. Wenzel D, Zapf A (2013) Difference of two dependent sensitivities and specificities: comparison of various approaches. Biomedical Journal 55: 705-18. [Abstract]
  21. Andruszkow H, Scharff B, Zapf A, Klein M, Lerchler P, Hildebrand F, Frink M (2013). Influence of comorbidities and delay in surgical treatment on mortality following femoral neck fracture. Z Orthop Unfall 151: 338-42. [Abstract]
  22. Körner S, Hendricks M, Kollewe K, Zapf A, Dengler R, Silani V, Petri S. (2013) Weight loss, dysphagia and supplement intake in patients with amyotrophic lateral sclerosis (ALS): impact on quality of life and therapeutic options BMC Neurol 13: 84. [Abstract]
  23. Moll MA, Seuthe M, von See C, Zapf A, Hornecker E, Mausberg RF, Ziebolz D. (2013) Comparison of clinical and dental panoramic findings: a practice-based crossover study BMC Oral Health 13: 48. [Open access]
  24. Fuchs M, Beißbarth T, Wingender E and Jung K (2013) Connecting high-dimensional mRNA and miRNA expression data for binarymedical classification problems. Computer Methods and Programs in Biomedicine 111: 592-601. [Abstract]
  25. Leha A, Jung K and Beißbarth T (2013) Utilization ofordinal response structures in classification with high-dimensionalexpression data. Proceedings of the German Conference on Bioinformatics 34: 90-100. [Abstract]
  26. Schneider S, Schmidli H, Friede T (2013) Robustness of methods for blinded sample size reestimation with overdispersed count data. Statistics in Medicine 32: 3623–3635. [Abstract]
  27. Koziolek MJ, Mühlhausen J, Friede T, Ellenberger D, Sigler M, Gärtner J, Müller GA, Huppke P (2013) Therapeutic apheresis in pediatric patients with acute CNS inflammatory demyelinating disease. Blood Purification 36: 92–97. [Full text]
  28. Salendo J, Spitzner M, Kramer F, Zhang X, Jo P, Wolff HA, Kitz J,Kaulfuß S, Beißbarth T, Dobbelstein M, Ghadimi M, Grade M, Gaedcke J. (2013) Identification of a microRNA expression signature forchemoradiosensitivity of colorectal cancer cells, involving miRNAs-320a,-224, -132 and let7g. Radiother Oncol 108: 451-457. [Abstract]
  29. Spitzner M, Roesler B, Bielfeld C, Emons G, Gaedcke J, Wolff HA,Rave-Fränk M, Kramer F, Beissbarth T, Kitz J, Wienands J, Ghadimi BM,Ebner R, Ried T, Grade M. (2013) STAT3 inhibition sensitizes colorectal cancer to chemoradiotherapy in vitro and in vivo. Int J Cancer 134: 997-1007. [Abstract]
  30. Körner S, Siniawski M, Kollewe K, Rath KJ, Krampfl K, Zapf A, Dengler R, Petri S (2013). Speech therapy and communication device: Impact on quality of life and mood in patients with amyotrophic lateral sclerosis. Amyotroph Lateral Scler 14: 20-5. [Abstract]
  31. Pape L, Ahlenstiel T, Werner CD, Zapf A (2013). Development and validation of a new statistical model for prognosis of long-term graft function after pediatric kidney transplantation. Pediatr Nephrol, 28: 499-505. [Abstract]
  32. Goldschmidt I, Streckenbach C, Dingemann C, Pfister ED, di nanni A, Zapf A, Baumann U (2013). Application and limitations of transient liver elastography in children. J Pediatr Gastroenterol Nutr 57: 109-113. [Abstract]
  33. Konietschke F, Bösiger S, Brunner E, Hothorn LA (2013). Are Multiple Contrast Tests Superior to the ANOVA? The International Journalof Biostatistics 9: 1- 11.[Abstract].
  34. Kombrink K, Munk A, Friede T (2013) Design and semiparametric analysis of non-inferiority trials with active and placebo control for censored time to event data. Statistics in Medicine 32: 3055-3066. [Abstract].
  35. Russo SG, Stradtmann C, Crozier TA, Ringer C, Helms HJ, Quintel M, Wiese CH. (2013) Bag-mask ventilation and direct laryngoscopy versus intubating laryngeal mask airway: a manikin study of hands-on times during cardiopulmonaryresuscitation. European Journal of Emergency Medicine 21: 189–194. [Abstract]
  36. Knösel M, Eckstein A, Helms H-J (2013) Durability of esthetic improvement following infiltration (ICON) of multibracket-induced white-spot lesions compared to no therapy over six months - a single-centersplit-mouth randomized clinical trial. American Journal of Orthodontics and Dentofacial Orthopedics 144: 86-96.[Abstract]
  37. Beyer F, Hertel D, Jung K, Fender AC, Leuschner C (2013) Competition effects on fine root survival of Fagus sylvatica and Fraxinus excelsior. Forest Ecology and Management 302: 14-22. [Abstract]
  38. Friede T, Kieser M (2013) Blinded sample size re-estimation in superiority and non-inferiority trials: Bias versus variance in variance estimation. Pharmaceutical Statistics 12: 141–146. [Abstract]
  39. Patel S, Friede T, Froud R, Evans DW, Underwood M (2013) Systematic review of randomised controlled trials of clinical prediction rules for physical therapy in low back pain. Spine 38: 762–769. [Abstract].
  40. Kieser M, Friede T, Gondan M (2013) Assessment of statistical significance and clinical relevance. Statistics in Medicine 32: 1707–1719. [Abstract]
  41. Conradi LC, Styczen H, Sprenger T, Wolff HA, Rödel C, Nietert M, Homayounfar K, Gaedcke J, Kitz J, Talaulicar R, Becker H, Ghadimi M, Middel P, Beißbarth T, Rüschoff J, Liersch T (2013) Frequency of HER-2 Positivity in Rectal Cancer and Prognosis. Am J Surg Pathol 37: 522-531. [Abstract]
  42. Rinke S, Lange K, Ziebolz D. (2013) Retrospective Study of Extensive Heat-Pressed Ceramic Veneers after 36 Month. Journal of Esthetic and Restorative Dentistry 25: 42-52.[Abstract]
  43. Rinke S, Schäfer S, Lange K, Gersdorff N, Roediger M. (2013) Practice-based clinical evaluation of metal-ceramic and zirconia molar crowns: 3 year result. Journal of Oral Rehabilitation 40: 228-37 [Abstract]
  44. Taggart F, Friede T, Weich, Clarke A, Johnson MR, Stewart-Brown SL.(2013) Cross cultural evaluation of the Warwick-Edinburgh Mental Well-Being Scale (WEMWBS). A mixed methods study. Health and Quality of Life Outcomes 11: 27. [Open Access]
  45. Lange K, Brunner E (2013) Analysis of Predictive Values Based on Individual Risk Factors in Multi-Modality Trials. Diagnostics 3: 192-209 [Open Access]
  46. Kretschmer L, Sahlmann CO, Bardzik P, Mitteldorf C, Helms HJ, Meller J, Schön MP, Bertsch HP. (2013) Individualized Surgery: Gamma-Probe-Guided Lymphadenectomy in Patients with Clinically Enlarged Lymph Node Metastases from Melanomas Annals of Surgical Oncology 20: 1714–1721. [Abstract]
  47. Heeg MHJ, Mueller GA, Bramlage C, Homayounfar K, Muehlhausen J, Leha A, Koziolek MJ(2013) Improvement of Renal Graft Function After Conversion From a Calcineurin Inhibitor Including Immunosuppression to a Mycophenolate Sodium Including Regimen: A 4-year Follow-up Transplantation proceedings 45: 142-147. [Abstract].
  48. Tirilomis T, Zwiehoff JM, Waldmann-Beushausen R, Schneider S, Schoendube FA. (2013) The Effect of Cardiopulmonary Bypass and Hypothermic Circulatory Arrest on Hepatic Histology in Newborn Animals: An Experimental Stud. Artificial Organs 37: E35-E39. [Abstract]
  49. Sprenger T, Conradi LC, Beißbarth T, Ermert H, Homayounfar K, Middel P, Rüschoff J, Wolff HA, Schüler P, Ghadimi BM, Rödel C, Becker H, Rödel F, Liersch T. (2013) Enrichment of CD133-expressing cells in rectal cancers treated with preoperative radiochemotherapy is an independent marker for metastasis and survival. Cancer 119: 26-35. [Abstract]
  50. Schneider S, Schmidli H, Friede T (2013) Blinded and unblinded internal pilot study designs for clinical trials with count data. Biometrical Journal 55: 617-633. [Abstract].



  1. Nikolin, VM, Osterrieder K, von Messling V, Hofer H, Anderson D, Dubovi E, Brunner E, East ML (2012). Antagonistic Pleiotropy and Fitness Trade-offs Reveal Specialist and Generalist Traits in Strains of Canine Distemper Virus. PLoSONE 7: e50955. [Open access].
  2. Rödig T, Hausdörfer T, Konietschke F , Dullin C, Hahn W, Hülsmann M (2012). Efficacy of D-RaCe and ProTaper Universal Retreatment NiTi-instruments in removing gutta-percha from curved root canals - a micro-computed tomography study. International Endodontic Journal 45: 580-9. [Abstract].
  3. Knösel M, Engelke W, Helms H-J, Bleckmann A(2012) An appraisal of the current and potential value of Web 2.0 contributions to continuing education in oral implantology European Journal of Dental Education, 16: 131-13.[Abstract].
  4. Stockhammer F, Misch M, Helms HJ, Lengler U, Prall F, von Deimling A, Hartmann C (2012) IDH1/2 mutations in WHO grade II astrocytomas associated with localization and seizure as the initial symptom Seizure 21: 194-197.[Abstract].
  5. Hartmann J, Braulke F, Sinzig U, Wulf G, Maas JH, Konietschke F, Haase D (2012). Iron overlaod influences the hematological stem cell function in patients with myelodysplastic syndromes. Leukemia Research 37: 327—332. [Abstract].
  6. Bleckmann A, Siam L, Klemm F, Rietkötter E, Wegner C, Kramer F, Beißbarth T, Binder C, Stadelmann C, Pukrop T. (2012) Nuclear LEF1/TCF4 correlate with poor prognosis but not with nuclear beta-Catenin in cerebral metastasis of lung adenocarcinomas. Clin Exp Metastasis 30: 471-82. [Abstract]
  7. Brunner E, Bathke A, Placzek M (2012). Estimation of Box’s ε for Low- and High-Dimensional Repeated Measures Designs with Unequal Covariance Matrices. Biometrical Journal 54: 301–316. [Abstract]
  8. Temme J, Kramer A, Jager KJ, Lange K, Peters F, Müller GA, Kramar R, Heaf JG, Finne P, Palsson R, Reisæter AV, Hoitsma AJ, Metcalfe W, Postorino M, Zurriaga O, Santos JP, Ravani P, Jarraya F, Verrina E, Dekker FW, Gross O. (2012) Outcomes of male patients with Alport syndrome undergoing renal replacement therapy . Clinical Journal of the American Society of Nephrology. 7: 1969-76. [Abstract].
  9. Rinke S, Gersdorff N, Lange K, Roediger M. (2012) Prospective Evaluation of Zirconia Posterior Fixed Partial Dentures: 7-Year Clinical Results. International Journal of Prosthodontics and Restorative Dentistry 26: 164-71[Abstract].
  10. Koziolek M, Datta R D, Mattes H, Jung K, Heise D, Streich J H, Mühlhausen J, Mueller G A, and Dihazi H (2012) Predictors of renal replacement therapy in acute kidney injury. Nephron Extra 2: 247-255. [Abstract].
  11. Knösel M, Forslund L, Jung K and Ziebolz D (2012) Efficacy of different strategies in protecting enamel against demineralization during fixed orthodontic treatment. Journal of Orofacial Orthopedics 73: 194-203.[Abstract].
  12. Roessler M, Schmid D S, Michels P, Schmid O, Jung K, Stoeber J, Neumann P, Quintel M and Moerer O (2012) Early out-of-hospital non-invasive ventilation is superior to standard medical treatment in patients with acute respiratory failure: a pilot study. Emergency Medicine Journal 29: 409-414. [Abstract]
  13. Hennies S., Wolff H.A., Jung K., Rave-Fränk M., Gaedcke J., Ghadimi M., Hess C.F., Becker H., Hermann R.H. and Christiansen H. (2012) Influence of testicular radiation dose on hormone levels, quality of life and sexual functioning in patients treated with multimodal curative therapy (neoadjuvant radiochemotherapy, surgery, and adjuvant chemotherapy) forlocally advanced rectal cancer. Strahlentherapie und Onkologie 188: 926-932. [Abstract]
  14. Xyda A, Haberland U, Klotz E, Jung K, Bock HC, Schramm R, Knauth M, Schramm P (2012) Diagnostic performance of whole brain volume perfusion CT in intra-axial brain tumors: Preoperative classification accuracy and histopathologic correlation. European Journal of Radiology 81: 4105-4111. [Abstract]
  15. Brunner E, Herrmann-Lingen C (2012) Bibliometrie in der Medizin – die Position der AWMF [Open Access]
  16. Ziebolz D, Priegnitz A, Hasenfuss G, Helms HJ, Hornecker E, Mausberg RF. (2012) Oral health status of patients with acute coronary syndrome--a case control study BMC Oral Health.[Abstract]
  17. Ziebolz D, Hildebrand A, Proff P, Rinke S, Hornecker E, Mausberg RF, Helms H-J. (2012) Response to the letter to the editor: “Design and analytical issues: a response to ‘Long-term effects of tongue piercing—a case control study’” [Abstract]
  18. Maier IL, Bauerle M, Kermer P, Helms HJ, Buettner T. (2012) Risk prediction of very early recurrence, death and progression after acute ischaemic stroke Eur J Neurol 20: 599-604.[Abstract]
  19. Heuer JF, Sauter P, Barwing J, Herrmann P, Crozier TA, Bleckmann A, Beißbarth T, Moerer O, Quintel M. (2012) Effects of High-frequency Oscillatory Ventilation on Systemic and Cerebral Hemodynamics and Tissue Oxygenation: An Experimental Study in Pigs. Neurocrit Care 17: 281-92. [Abstract]
  20. Pelczar P, Zibat A, van Dop WA, Heijmans J, Bleckmann A, Gruber W, Nitzki F, Uhmann A, Guijarro MV, Hernando E, Dittmann K, Wienands J, Dressel R, Wojnowski L, Binder C, Taguchi T, Beißbarth T, Hogendoorn PC, Antonescu CR, Rubin BP, Schulz-Schaeffer W, Aberger F, van den Brink GR, Hahn H. (2012) Inactivation of Patched1 in Mice Leads to Development of Gastrointestinal Stromal-Like Tumors That Express Pdgfr(alpha) but Not Kit. Gastroenterology 144: 134-144.e6. [Abstract]
  21. Gaedcke J, Grade M, Camps J, Søkilde R, Kaczkowski B, Schetter AJ, Difilippantonio MJ, Harris CC, Ghadimi BM, Møller S, Beißbarth T, Ried T, Litman T. (2012) The rectal cancer microRNAome--microRNA expression in rectal cancer and matched normal mucosa. Clin Cancer Res 18: 4919-30. [Abstract]
  22. Raupach T, Schiekirka S, Münscher C, Beißbarth T, Himmel W, Burckhardt G, Pukrop T. (2012) Piloting an outcome-based programme evaluation tool in undergraduate medical education. GMS Z Med Ausbild 29: 44. [Abstract]
  23. Amanzada A, Goralczyk AD, Schneider S, Moriconi F, Lindhorst A, Mihm S, van Thiel H, Ramadori G. (2012) High Predictability of a Sustained Virological Response (87%) in Chronic Hepatitis C Virus Genotype 1 Infection Treatment by Combined IL28B Genotype Analysis and γ-Glutamyltransferase/Alanine Aminotransferase Ratio: A Retrospective Single-Center Study Digestion 86: 218-227. [Full tetx]
  24. Konietschke F, Pauly M (2012). Bootstrapping and Permuting paired t-test type statistics. Statistics and Computing 24: 283–296. [Abstract]
  25. Fromm-Dornieden C, Lytovchenko O, von der Heyde S, Behnke N, Hogl S, Berghoff J, Köpper F, Opitz L, Renne U, Höflich A, Beißbarth T, Brenig B, Baumgartner BG (2012) Extrinsic and intrinsic regulation of DOR/TP53INP2 expression in mice: effects of dietary fat content, tissue type and sex in adipose and muscle tissues. Nutrition & Metabolism 9: 86. [Abstract]
  26. Friede T, Parsons N, Stallard N (2012) A conditional error function approach for subgroup selection in adaptive clinical trials. Statistics in Medicine 31: 4309-4320. [Abstract]
  27. Pugliatti M, Eskic D, Mikolcić T, Pitschnau-Michel D, Myhr K-M, Sastre-Garriga J, Otero S, Wieczynska L, Torje C, Holloway E, Rienhoff O, Friede T, Buckow K, Ellenberger D, Hillert J, Glaser A, Flachenecker P, Fuge J, Schyns-Liharska T, Kasilingam E, Moretti A, Thalheim C for the EUReMS Consortium. (2012) Assess, compare and enhance the status of Persons with Multiple Sclerosis (MS) in Europe: a European Register for MS. Acta Neurologica Scandinavica 126: 24–30. [Abstract]
  28. Bleckmann A, Siam L, Klemm F, Rietkötter E, Wegner C, Kramer F, Beißbarth T, Binder C, Stadelmann C, Pukrop T. (2012) Nuclear LEF1/TCF4 correlate with poor prognosis but not with nuclear ß-catenin in cerebral metastasis of lung adenocarcinomas. Clin Exp Metastasis 30: 471-482 [Abstract]
  29. Nicholas R, Friede T (2012) Considerations in the design of clinical trials for relapsing multiple sclerosis. Clinical Investigation 2: 1073-1083. [Abstract]
  30. Goralczyk AD, Bari N, Abu-Ajaj W, Lorf T, Ramadori G, Friede T, Obed A (2012) Calcineurin inhibitor sparing with mycophenolate mofetil in liver transplantion: a systematic review of randomized controlled trials. American Journal of Transplantation 12: 2601–2607. [Abstract]
  31. Konietschke F, Hothorn LA (2012). Evaluation of toxicological studies using a non-parametric Shirley-type trend test for comparing several dose levels with a control group. Statistics in Biopharmaceutical Research 4: 14-27. [Abstract]
  32. Noguchi K, Gel Y, Brunner E, Konietschke F (2012). nparLD: An R Software Package for the Nonparametric Analysis of Longitudinal Data in Factorial Experiments. Journal of Statistical Software 50: 1-23. [Abstract]
  33. Konietschke F, Libiger O, Hothorn LA (2012). Nonparametric Evaluation of Quantitative Traits in Population-based Association Studies when the Genetic Model is Unknown, PLoS ONE 7: e31242. [Open access]
  34. Prenzel T, Kramer F, Bedi U, Nagarajan S, Beißbarth T, Johnsen SA (2012) Cohesin is required for expression of the estrogen receptor-alpha (ESR1) gene. Epigenetics Chromatin 5: 13. [Abstract]
  35. Rinke S, Fornefett D,Gersdorff N, Lange K, Roediger M. (2012) Multifactorial analysis of the impact of different manufacturing processes on the marginal fit of zirconia copings. Dental Materials Journal 31: 601-609. [Abstract]
  36. Benhaiem S, Hofer H, Kramer-Schadt S, Brunner E and East M.L (2012) Sibling rivalry: training effects, emergence of dominance and incomplete control Proc. R. Soc. B 279: 3727–3735 [Abstract]
  37. Koziolek MJ, Tampe D, Bähr M, Dihazi D, Jung K, Fitzner D, Klingel R, Müller GA and Kitze B (2012): Immunoadsorption therapy in MS patients with steroid-refractory optical neuritis. Journal of Neuroinflammation 9:80. [Abstract]
  38. Knösel M, Bojes M, Jung K and Ziebolz D (2012): Increased susceptibility for white-spot lesions by surplus orthodontic etching exceeding bracket base area. American Journal of Orthodontics and Dentofacial Orthopedics 141: 574-582. [Abstract]
  39. Jung K, Engelke W and Knösel M (2012) Statistical Signal Processing Methods for Intra-oral Pressure Curve Analysis in Orthodontics. European Journal of Orthodontics 34: 437-441. [Abstract]
  40. Artmann S, Jung K, Bleckmann A, Beißbarth T. (2012) Detection of simultaneous Group Effects in microRNA Expression and related Target Gene Sets. PLoS ONE 7: e38365. [Abstract]
  41. Nicholas R, Straube S, Schmidli H, Pfeiffer S, Friede T (2012) Time-patterns of annualized relapse rates in randomized placebo-controlled clinical trials in relapsing multiple sclerosis: A systematic review and meta-analysis. Multiple Sclerosis Journal 18: 1290-1296. [Abstract]
  42. Henjes F, Bender C, von der Heyde S, Braun L, Mannsperger HA, Schmidt C, Wiemann S, Hasmann M, Aulmann S, Beißbarth T, Korf U. (2012) Strong EGFR signaling in cell line models of ERBB2-amplified breast cancer attenuates response towards ERBB2-targeting drugs. Oncogenesis 1: e16. [Abstract]
  43. Konietschke F (2012). Book Review: Multiple Testing Problems in Pharmaceutical Statistics (Dmitrienko, A., Tamhane, A. C., Bretz, F.), The Biometrical Journal 54: 579-580. [Abstract]
  44. Konietschke F, Pauly M (2012). A studentized permutation test for the nonparametric Behrens-Fisher problem in paired data. The Electronic Journal of Statistics 6: 1358-1372. [Abstract]
  45. Gross O, Friede T, Hilgers R, Görlitz A, Gavenis K, Ahmed R, Dürr U (2012) Safety and efficacy of the ACE-inhibitor ramipril in Alport syndrome: The double-blind, randomized, placebo-controlled, multicenter phase III EARLY PRO-TECT Alport trial in pediatric patients. ISRN Pediatrics 2012: 436046. [Abstract]
  46. Friede T, Miller F (2012) Blinded continuous monitoring of nuisance parameters in clinical trials. Journal of the Royal Statistical Society Series C 61: 601–618. [Abstract].
  47. Lange K, Bähr M, Hein K.(2012) Author response: retinal nerve fiber layer thickness measurements in rats with the spectral domain optical coherence tomography. Investigative Ophthalmology & Visual Science 53: 3570-3571. [Abstract]
  48. Temme J, Peters F, Lange K, Pirson Y, Heidet L, Torra R, Grunfeld JP, Weber M, Licht C, Müller GA, Gross O. (2012) Incidence of renal failure and nephroprotection by RAAS inhibition in heterozygous carriers of X-chromosomal and autosomal recessive Alport mutations. Kidney international 81: 779-783. [Abstract]
  49. Hein K, Gadjanski I, Kretzschmar B, Lange K, Diem R, Sättler MB, Bähr M. (2012) An optical coherence tomography study on degeneration of retinal nerve fiber layer in rats with autoimmune optic neuritis. Investigative Ophthalmology & Visual Science 53: 157-163. [Abstract]
  50. Gross O , Licht C, Anders HJ, Hoppe B, Beck B, Tönshoff B, Höcker B, Wygoda S, Ehrich JHH, Pape L, Konrad M, Rascher W, Dötsch J, Müller-Wiefel DE, Hoyer P, and Study Group Members of the Gesellschaft für Pädiatrische Nephrologie (GPN), Knebelmann B, Pirson Y, Grunfeld JP, Niaudet P, Cochat P, Heidet L, Torra R, Friede T, Lange K, Müller GA, Weber M. (2012). Early angiotensin-converting enzyme inhibition in Alport syndrome delays renal failure and improves life expectancy. Kidney International 81: 494-501. [Open access]
  51. Konietschke F, Harrar SW, Lange K, Brunner E (2012). Ranking procedures for matched pairs with missing values - Asymptotic theory and a small sample approximation. Computational Statistics & Data Analysis 56: 1090-1102. [Abstract]
  52. Ali A, Christensen N, Meyer R, Röver C (2012) Bayesian inference on EMRI signals using low frequencyapproximations. Classical and Quantum Gravity, 29(14):145014. [Abstract]
  53. Homayounfar K, Bleckmann A, Conradi LC, Sprenger T, Beißbarth T, Lorf T, Niessner M, Sahlmann CO, Meller J, Becker H, Liersch T, Ghadimi BM. (2012) Bilobar spreading of colorectal liver metastases does not significantly affect survival after R0 resection in the era of interdisciplinary multimodal treatment. International Journal of Colorectal Disease 27: 1359-1367. [Abstract]
  54. Strobel L, Schneider NK, Krampe H, Beißbarth T, Pukrop T, Anders S, West R, Aveyard P, Raupach T. (2012) German medical students lack knowledge of how to treat smoking and problem drinking. Addiction 107: 1878-1882. [Abstract]
  55. Karpiuk O, Najafova Z, Kramer F, Hennion M, Galonska C, König A, Snaidero N, Vogel T, Shchebet A, Begus-Nahrmann Y, Kassem M, Simons M, Shcherbata H, Beißbarth T, Johnsen SA. (2012) The Histone H2B Monoubiquitination Regulatory Pathway Is Required for Differentiation of Multipotent Stem Cells. Mol Cell 46: 705-13. [Abstract]
  56. Sauer R, Liersch T, Merkel S, Villanueva MT, Fietkau R, Hohenberger W, Hess C, Becker H, Raab HR, Witzigmann H, Wittekind C, Beißbarth T, Rödel C.(2012) Preoperative versus postoperative chemoradiotherapy for locally advanced rectal cancer: Results of the German CAO/ARO/AIO-94 randomized phase III trial after a median follow up of 11 years. Journal of Clinical Oncology 30: 1926-1933. [Abstract]
  57. Schirmer MA, Nadine Mergler CP, Rave-Fränk M, Herrmann MK, Hennies S, Gaedcke J, Conradi LC, Jo P, Beißbarth T, Hess CF, Becker H, Ghadimi M, Brockmöller J, Christiansen H, Wolff HA. (2012) Acute Toxicity of Radiochemotherapy in Rectal Cancer Patients: A Risk Particularly for Carriers of the TGFB1 Pro25 variant. Int J Radiat Oncol Biol Phys 83: 149-157. [Abstract]
  58. Gerlinger C, Edler L, Friede T, Kieser M, Nakas CT, Schumacher M, Seldrup J, Victor N (2012) Considerations on what constitutes a ”Qualified Statistician” in regulatory guidelines. Statistics in Medicine 31: 1303–1305. [Abstract]
  59. von der Heyde S, Beißbarth T (2012) A new analysis approach of epidermal growth factor receptor pathway activation patterns provides insights into cetuximab resistance mechanisms in head and neck cancer. BMC Medicine 10: 43. [Open access]
  60. Fromm-Dornieden C, von der Heyde S, Lytovchenko O, Salinas-Riester G, Brenig B, Beißbarth T, Baumgartner BG (2012) Novel polysome messages and changes in translational activity appear after induction of adipogenesis in 3T3-L1 cells. BMC Molecular Biology 13: 9. [Abstract]
  61. Homayounfar K, Meis J, Jung K, Klosterhalfen B, Sprenger T, Conradi LC, Langer C, Becker H (2012) Ultrasonic scalpel causes greater depth of soft tissue necrosis compared to monopolar electrocautery at standard power level settings in a pig model. BMC Surgery 12: 3. [Abstract]
  62. Lee D-H, Geyer E, Flach A-C, Jung K, Gold R, Flügel A, Linker R A, Lühder F (2012) Central nervous system rather than immune cell-derived BDNF mediates axonal protective effects early in autoimmune demyelination. Acta Neuropathologica 123: 247-258. [Abstract]
  63. Alt-Epping B, Nejad RK, Jung K, Groß U, Nauck F (2012) Symptoms of the oral cavity and their associations with local microbiological and clinical findings – a prospective survey in palliative care. Support Care Cancer 20: 531-537. [Abstract]
  64. Jo P, Jung K, Grade M, Conradi LC, Wolff HA, Kitz J, Rüschoff J, Hartmann A, Becker H, Beißbarth T, Müller A, Ghadimi MB, Schneider-Stock R, Gaedcke R. (2012) CpG island methylator phenotype infers a poor prognosis in locally advanced rectal cancer. Surgery 151: 564-570. [Abstract]
  65. Pratsch AL, Schneider S, Kretschmer L (2012) Schwellungsempfinden, klinische Schwellungszeichen und manifestes Lymphödem –Schwierigkeiten bei der Quantifizierung von Beinschwellungen. Phlebologie 41: 5-11. [Abstract]
  66. Seegers J, Vos MA, Willems R, Flevari P, Dorenkamp M, Sohns C, Vollmann D, Lüthje L, Kremastinos DT, Floré V, Meine M, Tuinenburg A, Connelly DT, Myles RC, Marshall GE, Simon D, Brockmöller J, Friede T, Hasenfuß G, Lehnart SE, Zabel M for the EUTrigTreat Clinical Study Investigators (2012) Rationale, objectives and design of the EUTrigTreat Clinical Study: A prospective observational study for arrhythmia risk stratification and assessment of interrelationships among repolarisation markers and genotype. EP-Europace 14: 416–422. [Open access]
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  68. Parsons N, Friede T, Todd S, Valdés-Márquez E, Chataway J, Nicholas R, Stallard N (2012) An R package for implementing simulations for seamless phase II/III clinical trials using early outcomes for treatment selection. Computational Statistics and Data Analysis 56: 1150-1160. [Abstract]
  69. Heuer JF, Sauter P, Pelosi P, Herrmann P, Brück W, Perske C, Schoendube F, Crozier TA, Bleckmann A, Beißbarth T, Quintel M (2012) Effects of Pulmonary Acid Aspiration on the lungs and extra-pulmonary organs: A randomized study in pigs. Critical Care 16: R35. [Abstract]
  70. Hummon AB, Pitt JJ, Camps J, Emons G, Skube SB, Huppi K, Jones TL, Beißbarth T, Kramer F, Grade M, Difilippantonio MJ, Ried T, Caplen NJ (2012) Systems-wide RNAi analysis of CASP8AP2/FLASH shows transcriptionalderegulation of the replication-dependent histone genes and extensive effects on the transcriptome of colorectal cancer cells Mol Cancer 11: 1. [Abstract]
  71. Raupach T, Schiekirka S, Münscher C, Beißbarth T, Himmel W, Burckhardt G, Pukrop T (2012) Implementierung und Erprobung eines Outcome-orientierten Evaluationssystems im Studium der Humanmedizin. GMS Zeitschrift für Medizinische Ausbildung 229: 44. [Abstract]



  1. Kendziorra E, Ahlborn K, Spitzner M, Rave-Fränk M, Emons G, Gaedcke J, Kramer F, Wolff HA, Becker H, Beißbarth T, Ebner R, Ghadimi BM, Pukrop T, Ried T, Grade M. (2011) Silencing of the Wnt transcription factor TCF4 sensitizes colorectal cancer cells to (chemo-) radiotherapy. Carcinogenesis 32: 1824-1831. [Abstract].
  2. Ziebolz D, Pabel SO, Lange K, Krohn-Grimberghe B, Hornecker E, Mausberg RF. (2011) Clinical Periodontal and Microbiologic Parameters in Patients with Rheumatoid Arthritis. J Periodontology 82: 1424-1432. [Abstract]
  3. Hahn W, Wasser-Merkel W, Lange K, Gruber RM, Kubein-Meesenburg D ; Ihlow, D. (2011). Accuracy of fit of 3-to-3 retainers after adhesive fixation using a neodymium–iron–boron magnet chain. Journal of Orofacial Orthopedics / Fortschritte der Kieferorthopdie 72: 381-388. [Abstract]
  4. Konietschke F, Hothorn LA, Brunner E (2011). Rank-based multiple test procedures and simultaneous confidence intervals. The Electronic Journal of Statistics 6: 737-758. [Open access]
  5. Hahn W, Engelke B, Jung K, Dathe H, Kramer F-J, Rödig T, Kubein-Meesenburg D and Gruber R M (2011) The influence of occlusal forces on force delivery properties of aligners during rotation of an upper central incisor. Angle Orthdontist 6: 1057-1063. [Abstract]
  6. Psychogios M K, Wachter D, Mohr A, Schramm P, Frölich A-M, Jung K, Rohde V, Knauth M (2011) Feasibility of flat panel angiographic computed tomography after intravenous contrast agent application in the postoperative evaluation of patients with clipped aneurysms. American Journal of Neuroradiology 32: 1956-1962. [Abstract]
  7. Balcarek P, Jung K, Frosch K-H and Stürmer K M (2011) Value of the Tibial Tuberosity-Trochlear Groove Distance in Patellar Instability in the Young Athlete. American Journal of Sports Medicine 39: 1756–1762. [Abstract]
  8. Brase JC, Johannes M, Mannsperger H, Fälth M, Metzger J, Kacprzyk LA, Andrasiuk T, Gade S, Meister M, Sirma H, Sauter G, Simon R, Schlomm T, Beißbarth T, Korf U, Kuner R, Sültmann H (2011) TMPRSS2-ERG-specific transcriptional modulation is associated with prostate cancer biomarkers and TGF-beta signaling. BMC Cancer 11: 507. [Abstract]
  9. Gade S, Porzelius C, Fälth M, Brase JC, Wuttig D, Kuner R, Binder H, Sültmann H, Beißbarth T. (2011) Graph based fusion of miRNA and mRNA expression data improves clinical outcome prediction in prostate cancer. BMC Bioinformatics 12: 488.[Abstract]
  10. Schillinger W, Athanasiou T, Weicken N, Berg L, Tichelbäcker T, Puls M, Hünlich M, Wachter R, Helms HJ, Seipelt R, Schöndube FA, Hasenfuss G (2011) Impact of the learning curve on outcomes after percutaneous mitral valve repair with MitraClip and lessons learned after the first 75 consecutive patients European Journal of Heart Failure 13:1331-1339. [Abstract]
  11. Thapar A, Lane T, Nicholas R, Friede T, Ellis M, Assenheim J, Franklin IJ, Davies AH (2011) Systematic review of sonographic CCSVI findings in multiple sclerosis. Phlebology 26: 319-25. [Abstract]
  12. Prenzel T, Begus-Nahrmann Y, Kramer F, Hennion M, Hsu C, Gorsler T, Hintermair C, Eick D, Kremmer E, Simons M, Beißbarth T, Johnsen SA (2011). Estrogen-Dependent Gene Transcription in Human Breast Cancer Cells Relies upon Proteasome-Dependent Monoubiquitination of Histone H2B. Cancer Res 71: 5739-5753. [Abstract]
  13. Danner C.B., Hellms T., Jung K., Gunawan B., Didilis V., Füzesi L. and Schöndube F.A. (2011): Prognostic values of chromosomal imbalances in squamous cell carcinoma and adenocarcinoma of the lung. Annals of Thoracic Surgery 92: 1038-1043. [Abstract]
  14. Jung K., Goerdt C., Lange P., Blocher J., Djukic M., Gerber J., Spreer A., Nau R., Otto M., Schmidt H. (2011): The use of S100B and Tau Protein Concentrations in the Cerebrospinal Fluid for the Differential Diagnosis of Bacterial Meningitis: a Retrospective Analysis. European Neurology 66: 128-132. [Abstract]
  15. Nicholas R, Straube S, Schmidli H, Schneider S, Friede T (2011) Trends in annualized relapse rates in relapsing remitting multiple sclerosis and consequences for clinical trial design. Multiple Sclerosis Journal 17: 1211-1217. [Abstract]
  16. Bramlage CP, Müller GA, Tampe B, Bevanda J, Maatouk I, Koziolek M, Lange K, Ahrens K, Schmid H, Cohen CD, Bramlage P, Kretzler M, Strutz F. (2011) The role of bone morphogenetic protein-5 (BMP-5) in human nephrosclerosis. Journal of Nephrology, 24: 647-655. [Abstract]
  17. Rinke S, Ohl S, Ziebolz D, Lange K, Eickholz P. (2011) Prevalence of periimplant disease in partially edentulous patients: a practice-based cross-sectional study. Clinical Oral Implants Research 22: 826–833. [Abstract]
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  19. Xyda A, Haberland U, Klotz E, Bock H C, Jung K, Knauth M, Schramm R, Psychogios M N, Erb G, Schramm P (2011). Brain volume perfusion CT performed with 128-detector row CT system in patients with cerebral gliomas: A feasibility study. European Radiology 9: 1811-1819. [Abstract]
  20. Kretschmer L, Starz H, Thoms K-M, Satzger I, Völker B, Jung K, Mitteldorf C, Bader C, Siedlecki K, Kapp A, Bertsch H P and Gutzmer R (2011). Age as a key factor influencing metastasizing patterns and disease-specific survival after sentinel lymph node biopsy for cutaneous melanoma. International Journal of Cancer 6: 1435-1442. [Abstract]
  21. Danner B.C., Gerdes J.S., Enders C., Jung K., Sander B., Liersch T., Seipelt R., Gutenberg A., Gunawan B., Schöndube F.A. and Füzesi L. (2011). Comparison of chromosomal aberrations in primary colorectal carcinomas to their pulmonary metastases. Cancer Genetics 204: 122-128. [Abstract]
  22. Knösel M and Jung K (2011). Informational value and bias of videos related to orthodontics screened on a video-sharing Web site. Angle Orthodontist 81: 532-539. [Abstract]
  23. Raupach T, Münscher C, Beißbarth T, Burckhardt G, Pukrop T (2011). Towards outcome-based programme evaluation: Using student comparative self-assessments to determine teaching effectiveness. Med Teach 33: e446-e453 [Abstract]
  24. Wolff HA, Conradi LC, Schirmer M, Beißbarth T, Sprenger T, Rave-Fränk M, Hennies S, Hess CF, Becker H, Christiansen H, Liersch T. (2011) Gender-specific acute organ toxicity during intensified preoperative radiochemotherapy for rectal cancer. Oncologist 16: 621-631. [Abstract]
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  26. Jung K, Friede T, Beißbarth T (2011) Reporting FDR analogous confidence intervals for the log fold change of differentially expressed genes. BMC Bioinformatics 12: 288. [Open access]
  27. Clarke A, Friede T, Putz R, Ashdown J, Martin S, Blake A, Adi Y, Parkinson J, Flynn P, Platt S, Stewart-Brown S. (2011) Warwick-Edinburgh Mental Well-being Scale (WEMWBS): Validated for teenage school students in England and Scotland. A mixed methods assessment. BMC Public Health 11: 487. [Open access]
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  30. Nicholas R, Giannetti P, Alanousi A, Friede T, Muraro PA (2011) Development of oral immunomodulatory agents in the management of multiple sclerosis. Drug Design, Development and Therapy 5: 255–274. [Open access]
  31. Leha A, Beißbarth T, Jung K (2011) Sequential Interim Analyses of Survival Data in DNA Microarray Experiments. BMC Bioinformatics 12: 127. [Abstract]
  32. Jung K, Becker B, Brunner B, Beißbarth T (2011) Comparison of Global Tests for Functional Gene Sets in Two-Group Designs and Selection of Potentially Effect-causing Genes. Bioinformatics 27: 1377-1383. [ [Abstract]
  33. Johannes M, Fröhlich H, Sültmann H, Beißbarth T (2011) pathClass: An R-Package for Integration of Pathway Knowledge into Support Vector Machines for Biomarker Discovery. Bioinformatics 27: 1442-1443 [Abstract]
  34. Conradi LC, Bleckmann A, Schirmer M, Sprenger T, Jo P, Homayounfar K, Wolff HA, Rothe H, Middel P, Becker H, Ghadimi MB, Beißbarth T, Liersch T. (2011) Thymidylate Synthase as a Prognostic Biomarker for Locally Advanced Rectal Cancer after multimodal Treatment. Ann Surg Oncol 18: 2442-2452. [Abstract]
  35. Porzelius C, Johannes M, Binder H, BeißbarthT (2011) Leveraging external knowledge on molecular interactions inclassification methods for risk prediction of patients. Biometrical Journal 53: 190-201. [Abstract]
  36. Klemm F, Bleckmann A, Siam L, Chuang HN, Rietkötter E, Behme D, Schulz M, Schaffrinski M, Schindler S, Trümper L, Kramer F, Beißbarth T, Stadelmann C, Binder C, Pukrop T (2011) b-catenin-independent WNT signaling in basal-like breast cancer and brain metastasis. Carcinogenesis 32: 434-42. [Abstract]
  37. Hua TD, Vormfelde SV, Abu Abed M, Schneider-Rudt H, Sobotta P, Friede T, Chenot JF (2011) Practice nursed-based, individual and video-assisted patient education in oral anticoagulation - Protocol of a cluster-randomized controlled trial. BMC Family Practice 12: 17. [Open access]
  38. Wolff H A, Daldrup B, Jung K, Overbeck T, Hennies S, Matthias C, Hess C F, Roedel R M W, Christiansen H (2011) High-grade acute organ toxicity as positive prognostic factor in adjuvant radiation and chemotherapy for locally advanced head and neck cancer. Radiology 258: 864-871. [Abstract]
  39. Engelke W, Jung K and Knösel M (2011) Intra-oral compartment pressures: a biofunctional model and experimental measurements under different conditions of posture. Clinical Oral Investigations 15: 165-176. [Abstract]
  40. Wolff H A, Raus I, Jung K, Schüler P, Herrmann M K, Hennies S, Vorwerk H, Hille A, Hess C F and Christiansen H (2011) High-grade Acute Organ Toxicity as a Positive Prognostic Factor in Primary Radiochemotherapy for Anal Carcinoma. International Journal of Radiation Oncology Biology Physics 79: 1467-1478. [Abstract]
  41. Varges D, Jung K, Gawinecka J, Heinemann U, Schmitz M, von Ahsen N, Krasnianski A, Amstrong V W and Zerr I (2011) Amyloid-beta 1-42 levels are modified by Apolipoprotein E epsilon4 in Creutzfeldt-Jakob Disease in a similar manner as in Alzheimer's Disease. Journal of Alzheimer's Disease 23: 717-726. [Abstract]
  42. Patel S, Brown S, Friede T, Griffiths F, Lord J, Thistlethwaite J, Tysall C, Woolvine M, Underwood M (2011) Study protocol: Improving patient choice in treating low back pain (IMPACT - LBP): A randomised controlled trial of a decision support package for use in physical therapy. BMC Musculoskeletal Disorders 12: 52. [Open access]
  43. Wolff H A, Hennies S, Herrmann M K A, Rave-Fränk M, Eickelmann D, Virsik P, Jung K, Schirmer M, Ghadimi B M, Hess C F, Hermann R M and Christiansen H (2011) Comparison of micronucleus- and chromosome aberration technique for the documentation of cytogenic dam-age in radiochemotherapy treated patients with rectal cancer. Strahlentherapie und Onkologie 187: 52-58. [Abstract]
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  45. Bramlage C, Cuneo A, Härtel D, Jung K, Witteck C-H, Högel R, Müller G A, Bramlage P and Tebbe U (2011) Nierenarterienstenose: Intervention oder medikamentöse Behandlung? Deutsche Medizinische Wochenschrift 136: 76-81. [Abstract]
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  47. Chataway J, Nicholas R, Todd, S, Miller D, Parsons N, Valdés-Márquez E, Stallard N, Friede T (2011) A novel adaptive design strategy increases the efficiency of clinical trials in secondary progressive multiple sclerosis. Multiple Sclerosis 17: 81-88. [Abstract]



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  10. Lüers C, Hagenah G, Wachter R, Kleta S, Schaumberg J, Riedel S, Binder L, Jung K, Schmidt A and Pieske B (2010) Bedeutung der Surfactant-Proteine B und D in der Differentialdiagnostik der akuten Dyspnoe. Medizinische Klinik, 105, 611-618. [Abstract]
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  13. Schneider H, Kriebel T, Jung K, Gravenhorst V D and Paul T (2010) Catheter Ablation of Idiopathic Left and Right Ventricular Tachycardias in the Pediatric Population Using Noncontact Mapping. Heart Rhythm, 7, 731-739. [Abstract]
  14. Knösel M, Mattysek S, Jung K, Kubein-Meesenburg D, Sadat-Khonsari R and Ziebolz D (2010) Suitability of orthodontic brackets for rebonding and reworking following removal by air pressure pulses and conventional debracketing techniques. Angle Orthodontist, 80, 461-467. [Abstract]
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  13. Hagenah G, Zapf A, Schüttert JB (2009) Cheyne-Stokes Respiration and Prognosis in Modern-Treated Congestive Heart Failure. Lung. [Abstract]
  14. Hahn W, Dathe H, Fialka-Fricke J, Fricke-Zech S, Zapf A, Kubein-Meesenburg D, Sadat-Khonsari R (2009) Influence of thermoplastic appliance thickness on the magnitude of force delivered to a maxillary central incisor during tipping. Am J Orthod Dentofac ( ) 136: 12.e1-7; discussion 12-3. [Abstract]
  15. Hahn W, Fialka-Fricke J, Dathe H, Fricke-Zech S, Zapf A, Gruber R, Kubein-Meesenburg D, Sadat-Khonsari R (2009) Initial forces generated by three types of thermoplastic appliances on an upper central incisor during tipping. Eur J Orthodont . [Abstract]
  16. Hahn W, Fricke-Zech S, Fialka-Fricke J, Dullin C, Zapf A, Gruber R, Sennhenn-Kirchner S, Kubein-Meesenburg D, Sadat-Khonsari R (2009) Imaging of the midpalatal suture in a porcine model: flat-panel volume computed tomography compared with multislice computed tomography. Oral Surg Oral Med O ( ) 108: 443-9. [Abstract]
  17. Hahn W, Fricke-Zech S, Fricke J, Gruber Rudolf M, Dullin C, Zapf A, Hannig C, Kubein-Meesenburg D, Sadat-Khonsari R (2009) Detection and size differentiation of simulated tooth root defects using flat-panel volumecomputerized tomography (fpVCT). ORAL SURG ORAL MED O 107: 272-8. [Abstract]
  18. Hoff (2009) The effect of sequencing errors on metagenomic gene prediction. BMC GENOMICS 10: 520. [Abstract]
  19. Hoff KJ, Lingner T, Meinicke P, Tech M (2009) Orphelia: predicting genes in metagenomic sequencing reads. Nucleic Acids Res 37: W101-5. [Abstract]
  20. Hothorn T, Held L, Friede T (2009) Biometrical journal and reproducible research. Biom J 51: 553-5. [Abstract]
  21. Jung K, Poschmann G, Podwojski K, Eisenacher M, Kohl M, Pfeiffer K, Meyer HE, Stühler K, Stephan C (2009) Adjusted Confidence Intervals for the Expression Change of Proteins observed in 2-Dimensional Difference Gel Electrophoresis. Journal of Proteomics & Bioinformatics 2: 78-87. [Abstract]
  22. Kallenberg K, Bock HC, Helms G, Jung K, Wrede A, Buhk JH, Giese A, Frahm J, Strik H, Dechent P, Knauth M (2009) Untreated glioblastoma multiforme: increased myo-inositol and glutamine levels in the contralateral cerebral hemisphere at proton MR spectroscopy. Radiology 253: 805-812. [Abstract]
  23. Kertesz T, Herrmann MKA, Zapf A, Christiansen H, Hermann RM, Pradier O, Schmidberger H, Hess CF, Hille A (2009) Effect of a prostaglandin--given rectally for prevention of radiation-induced acute proctitis--on late rectal toxicity. Results of a phase III randomized, placebo-controlled, double-blind study. STRAHLENTHER ONKOL 185: 596-602. [Abstract]
  24. Knösel M, Attin R, Jung K, Brunner E, Kubein-Meesenburg D, Attin T (2009) Digital image color analysis compared to direct dental CIE colorimeter assessment under different ambient conditions. AM J DENT 22: 67-72. [Abstract]
  25. Knösel M, Jung K, Attin T, Attin R, Kubein-Meesenburg D, Gripp-Rudolph L (2009) Systematic evaluation of the features influencing the accuracy of third order measurements. Eur J Orthodont 31:547-555. [Abstract]
  26. Knösel M, Jung K, Attin T, Engelke W, Kubein-Meesenburg D, Gripp-Rudolph L, Attin R (2009) On the interaction between incisor crown-root morphology and third-order angulation. ANGLE ORTHOD, 79: 454-61. [Abstract]
  27. Knösel M, Jung K, Gripp-Rudolph L, Attin T, Attin R, Sadat-Khonsari R, Kubein-Meesenburg D, Bauss O (2009) Changes in incisor third-order inclination resulting from vertical variation in lingual bracket placement. ANGLE ORTHOD 79: 747-54. [Abstract]
  28. Koziolek MJ, Müller GA, Zapf A, Patschan D, Schmid H, Cohen CD, Koschnick S, Vasko R, Bramlage C, Strutz F (2009) Role of CX3C-chemokine CX3C-L/ fractalkine expression in a model of slowly progressive renal failure. Nephrol Dial Transplant. [Abstract]
  29. Langenfeld E, Zanger UM, Jung K, Meyer HE, Marcus K (2009) Mass spectrometry-based absolute quantification of microsomal cytochrome P450 2D6 in human liver. PROTEOMICS 9: 2313-23. [Abstract]
  30. Latif AHM, Bretz F, Brunner E (2009) Robustness Considerations in Selecting Efficient Two-Color Microarray Designs. Bioinformatics 25 2355–2361. [Abstract]
  31. Ling KH, Hewitt CA, Beißbarth T, Hyde L, Banerjee K, Cheah PS, Cannon PZ, Hahn CN, Thomas PQ, Smyth GK, Tan SS, Thomas T, Scott HS (2009) Molecular networks involved in mouse cerebral corticogenesis and spatio-temporal regulation of Sox4 and Sox11 novel antisense transcripts revealed by transcriptome profiling. Genome Biol 10: R104. [Abstract]
  32. Miller F, Friede T, Kieser M (2009) Blinded assessment of treatment effects utilizing information about the randomization block length. STAT MED, 28: 1690-706. [Abstract]
  33. Mitteldorf C, Bertsch HP, Zapf A, Neumann C, Kretschmer L (2009) Cutting a sentinel lymph node into slices is the optimal first step for examination of sentinel lymph nodes in melanoma patients. Modern Pathol 22: 1622-7. [Abstract]
  34. Nicholas RS, Friede T, Hollis S, Young CA (2009) Anticholinergics for urinary symptoms in multiple sclerosis. COCHRANE DB SYST REV 1: CD004193. [Abstract]
  35. Pavlakovi G, Züchner K, Zapf A, Bachmann CG, Graf BM, Crozier TA, Pavlakovi H (2009) Influence of intrinsic noise generated by a thermotesting device on thermal sensory detection and thermal pain detection thresholds. MUSCLE NERVE. [Abstract]
  36. Rödel RMW, Matthias C, Blomeyer BD, Wolff HA, Jung K, Christiansen H (2009) Impact of distant metastasis in patients with cervical lymph node metastases from cancer of an unknown primary site. ANN OTO RHINOL LARYN 118: 662-9. [Abstract]
  37. Sahin O, Fröhlich H, Löbke C, Korf U, Burmester S, Majety M, Mattern J, Schupp I, Chaouiya C, Thieffry D, Poustka A, Wiemann S, Beißbarth T, Arlt D (2009) Modeling ERBB receptor-regulated G1/S transition to find novel targets for de novo trastuzumab resistance. BMC Syst Biol 3: 1. [Abstract]
  38. Scheel AK, Matteson EL, Dasgupta B, Bruyn GAW, Ohrndorf S, Werner C, Schmidt WA (2009) Reliability exercise for the polymyalgia rheumatica classification criteria study: the oranjewoud ultrasound substudy. Int J Rheumatol, 2009: 738931. [Abstract]
  39. Schillinger W, Hörnes N, Teucher N, Sossalla S, Sehrt D, Jung K,Hünlich M, Unsöld B, Geiling B, Ramadori G, Hilgers R, Schwörer H, Hasenfuss G (2009) Recent in vitro findings of negative inotropy of pantoprazole did not translate into clinically relevant effects on left ventricular function in healthy volunteers. CLIN RES CARDIOL 98: 391-399. [Abstract]
  40. Stallard N, Posch M, Friede T, Koenig F, Brannath W (2009) Optimal choice of the number of treatments to be included in a clinical trial. STAT MED 28: 1321-38. [Abstract]
  41. Tezval M, Stuermer E, Sehmisch S, Rack T, Stary A, Stebener M, Konietschke F, Stuermer K (2009) Improvement of trochanteric bone quality in an osteoporosis model after short-term treatment with parathyroid hormone: a new mechanical test for trochanteric region of rat femur. Osteoporos Int. [Abstract]
  42. Vasko R, Koziolek M, Ikehata M, Rastaldi MP, Jung K, Schmid H, Kretzler M, Müller GA, Strutz F (2009) Role of basic fibroblast growth factor (FGF-2) in diabetic nephropathy and mechanisms of its induction by hyperglycemia in human renal fibroblasts. AM J PHYSIOL-RENAL 296: F1452-63. [Abstract]
  43. Ziebolz D, Herz A, Brunner E, Hornecker E, Mausberg RF (2009) Individual versus group oral hygiene instruction for adults. Oral Health Prev Dent 7: 93-9. [Abstract]



  1. Ahmad MR, Werner C, Brunner E (2008) Analysis of high-dimensional repeated measures designs: The one sample case. COMPUT STAT DATA AN 53: 416-27.
  2. Chapuy B, Koch R, Radunski U, Corsham S, Cheong N, Inagaki N, Ban N, Wenzel D, Reinhardt D, Zapf A, Schweyer S, Kosari F, Klapper W, Truemper L, Wulf GG (2008) Intracellular ABC transporter A3 confers multidrug resistance in leukemia cells by lysosomal drug sequestration. LEUKEMIA, 22(8): 1576-86.
  3. Dihazi H, Koziolek MJ, Söllner T, Kahler E, Klingel R, Neuhoff R, Strutz F, Mueller GA (2008) Protein adsorption during LDL-apheresis: proteomic analysis. NEPHROL DIAL TRANSPL, 23(9): 2925-35.
  4. Drengk A, Zapf A, Stürmer EK, Stürmer KM, Frosch KH (2008) Influence of Platelet-Rich Plasma on Chondrogenic Differentiation and Proliferation of Chondrocytes Mesenchymal Stem Cells. CELLS TISSUES ORGANS, 189(5): 317-26.
  5. Fialka F, Gruber RM, Hitt R, Opitz L, Brunner E, Schliephake H, Kramer FJ (2008) CPA6, FMO2, LGI1, SIAT1 and TNC are differentially expressed in early- and late-stage oral squamous cell carcinoma - A pilot study. ORAL ONCOL, 44(10): 941-8.
  6. Fricke M, Langer C, Brunner E, Sakai LY, Füzesi L, Reinhardt DP, Quondamatteo F (2008) Fibrillin-1 in incisional hernias: an immunohistochemical study in scar and non-scar regions of human skin and muscle fasciae. J ANAT, 212(5): 674-85.
  7. Hahn W, Fricke J, Fricke-Zech S, Zapf A, Gruber R, Sadat-Khonsari R (2008) The use of a neodymium-iron-boron magnet device for positioning a multi-stranded wire retainer in lingual retention--a pilot study in humans. EUR J ORTHODONT, 30(5): 433-6.
  8. Kahler E, Rogausch A, Brunner E, Himmel W (2008) A parametric analysis of ordinal quality-of-life data can lead to erroneous results. J CLIN EPIDEMIOL, 61(5): 475-80.
  9. Kociszewski J, Rautenberg O, Perucchini D, Eberhard J, Geissbühler V, Hilgers R, Viereck V (2008) Tape functionality: sonographic tape characteristics and outcome after TVT incontinence surgery. NEUROUROL URODYNAM, 27(6): 485-90.
  10. Krone B, Pohl D, Rostasy K, Kahler E, Brunner E, Oeffner F, Grange JM, Gärtner J, Hanefeld F (2008) Common infectious agents in multiple sclerosis: a case-control study in children. MULT SCLER, 14(1): 136-9.
  11. Lippert U, Zachmann K, Ferrari DM, Schwarz H, Brunner E, Latif AH, Neumann C, Soruri A (2008) Correction: CD137 ligand reverse signaling has multiple functions in human dendritic cells during an adaptive immune response. EUR J IMMUNOL, 38(6): 1767.
  12. Lippert U, Zachmann K, Ferrari DM, Schwarz H, Brunner E, Latif AH, Neumann C, Soruri A (2008) CD137 ligand reverse signaling has multiple functions in human dendritic cells during an adaptive immune response. EUR J IMMUNOL, 38(4): 1024-1032.
  13. Milsmann C, Füzesi L, Heinmöller E, Krause P, Werner C, Becker H, Horstmann O (2008) Morphological and immunohistochemical characterization of isolated tumor cells by p53 status in gastrointestinal tumors. LANGENBECK ARCH SURG, 393(1): 49-58.
  14. Müller T, Jung K, Ullrich A, Schrötter A, Meyer HE, Stephan C, Egensperger R, Marcus K (2008) Disease state, age, sex, and post-mortem time-dependent expression of proteins in AD vs. control frontal cortex brain samples. CURR ALZHEIMER RES, 5(6): 562-71.
  15. Pavlakovic G, Klinke I, Pavlakovic H, Züchner K, Zapf A, Bachmann CG, Graf BM, Crozier TA (2008) Effect of thermode application pressure on thermal threshold detection. MUSCLE NERVE, 38(5): 1498-505.
  16. Raupach T, Shahab L, Neubert K, Felten D, Hasenfuss G, Andreas S (2008) Implementing a hospital-based smoking cessation programme: evidence for a learning effect. PATIENT EDUC COUNS, 70(2): 199-204.
  17. Scholz KH, Hilgers R, Ahlersmann D, Duwald H, Nitsche R, von Knobelsdorff G, Volger B, Möller K, Keating FK (2008) Contact-to-balloon time and door-to-balloon time after initiation of a formalized data feedback in patients with acute ST-elevation myocardial infarction. AM J CARDIOL, 101(1): 46-52.
  18. Scholz KH, von Knobelsdorff G, Ahlersmann D, Keating FK, Jung J, Werner GS, Nitsche R, Duwald H, Hilgers R (2008) [Optimizing systems of care for patients with acute myocardial infarction. STEMI networks, telemetry ECG, and standardized quality improvement with systematic data feedback]. HERZ, 33(2): 102-9.
  19. Sennhenn-Kirchner S, Schwarz P, Schliephake H, Konietschke F, Brunner E, Borg-von Zepelin M (2008) Decontamination efficacy of erbium:yttrium aluminium-garnet and diode laser light on oral Candida albicans isolates of a 5-day in vitro biofilm model. LASER MED SCI.
  20. Song IH, Althoff CE, Hermann KG, Scheel AK, Knetsch T, Schoenharting M, Werner C, Burmester GR, Backhaus M (2008) Knee Osteoarthritis Efficacy of a new method of contrast-enhanced musculoskeletal ultrasonography in detection of synovitis in patients with knee osteoarthritis in comparison with magnetic resonance imaging. ANN RHEUM DIS, 67(1): 19-25.
  21. Toischer K, Kögler H, Tenderich G, Grebe C, Seidler C, van Nguyen P, Jung K, Knöll R, Körfer R, Hasenfuss G (2008) Elevated afterload, neuroendocrine stimulation and human heart failure increase BNP levels and inhibit preload-dependent SERCA upregulation. Circ Heart Fail, 1(4): 265-71.
  22. Waeschle RM, Moerer O, Hilgers R, Herrmann P, Neumann P, Quintel M (2008) The impact of the severity of sepsis on the risk of hypoglycaemia and glycaemic variability. CRIT CARE, 12(5): R129.
  23. Wiegand A, Buchholz K, Werner C, Attin T (2008) In vitro cytotoxicity of different desensitizers under simulated pulpal flow conditions. J ADHES DENT, 10(3): 227-32.
  24. Wiegand A, Müller I, Schnapp JD, Werner C, Attin T (2008) Impact of fluoride, milk and water rinsing on surface rehardening of acid softened enamel. An in situ study. AM J DENT, 21(2): 113-8.
  25. Ziebolz D, Schwerdtfeger B, Brunner E, Hornecker E, Mausberg RF (2008) [Oral health in young adults in Germany--a comparison between women and men of the German army]. Schweiz Monatsschr Zahnmed, 118(10): 944-50.



  1. Brockmann K, Becker P, Schreiber G, Neubert K, Brunner E, Bönnemann C (2007) Sensitivity and specificity of qualitative muscle ultrasound in assessment of suspected neuromuscular disease in childhood. NEUROMUSCULAR DISORD, 17(7): 517-23.
  2. Eich C, Bräuer A, Timmermann A, Schwarz SK, Russo SG, Neubert K, Graf BM, Aleksic I (2007) Outcome of 12 drowned children with attempted resuscitation on cardiopulmonary bypass: an analysis of variables based on the "Utstein Style for Drowning". RESUSCITATION, 75(1): 42-52.
  3. Elsner L, Muppala V, Gehrmann M, Lozano J, Malzahn D, Bickeböller H, Brunner E, Zientkowska M, Herrmann T, Walter L, Alves F, Multhoff G, Dressel R (2007) The heat shock protein HSP70 promotes mouse NK cell activity against tumors that express inducible NKG2D ligands . J IMMUNOL, 179(8): 5523-33.
  4. Happe S, Bachmann CG, Helmschmied K, Neubert K, Wuttke W, Paulus W, Trenkwalder C (2007) Growth hormone response to low-dose apomorphine in restless legs syndrome. GROWTH HORM IGF RES, 17(4): 323-7.
  5. Harms L, Emons G, Bader W, Lange R, Hilgers R, Viereck V (2007) Funneling before and after anti-incontinence surgery--a prognostic indicator? Part 2: tension-free vaginal tape. INT UROGYNECOL J, 18(3): 289-94.
  6. Heutelbeck AR, Janicke N, Hilgers R, Kütting B, Drexler H, Hallier E, Bickeböller H (2007) German cattle allergy study (CAS): public health relevance of cattle-allergic farmers. INT ARCH OCC ENV HEA, 81(2): 201-8.
  7. Koziolek MJ, Schmid H, Cohen CD, Blaschke S, Hemmerlein B, Zapf A, Müller GA, Strutz F (2007) Potential role of fractalkine receptor expression in human renal fibrogenesis. KIDNEY INT, 72(5): 599-607.
  8. Lehmann GB, Asskali F, Boll M, Burmeister MA, Marx G, Hilgers R, Förster H (2007) HES 130/0.42 shows less alteration of pharmacokinetics than HES 200/0.5 when dosed repeatedly. BRIT J ANAESTH, 98(5): 635-44.
  9. Lennon AM, Wiegand A, Buchalla W, Wahl B, Werner C, Betke H, Hannig C, Rödig T, Attin T (2007) Subjectivity and examiner experience in diagnosis of residual caries--an in vitro study. Schweiz Monatsschr Zahnmed, 117(2): 123-7.
  10. Mirzaie M, Brunner E, Mahbub-ul Latif AH, Schmitto J, Fatehpur S, Schöndube F (2007) A new storage solution for porcine aortic valves. Ann Thorac Cardiovasc Surg, 13(2): 102-9.
  11. Neubert K, Brunner E (2007) A studentized permutation test for the non-parametric Behrens-Fisher problem. COMPUT STAT DATA AN, 51(10): 5192-5204.
  12. Schillinger W, Teucher N, Sossalla S, Kettlewell S, Werner C, Raddatz D, Elgner A, Tenderich G, Pieske B, Ramadori G, Schöndube FA, Kögler H, Kockskämper J, Maier LS, Schwörer H, Smith GL, Hasenfuss G (2007) Negative inotropy of the gastric proton pump inhibitor pantoprazole in myocardium from humans and rabbits: evaluation of mechanisms. CIRCULATION, 116(1): 57-66.
  13. Thangavelu K, Brunner E (2007) Wilcoxon-Mann-Whitney Test for Stratified Samples and Efron's Paradox Dice. J STAT PLAN INFER, 137(3): 720-37.
  14. von Lewinski F, Werner C, Jörn T, Mohr A, Sixel-Döring F, Trenkwalder C (2007) T2*-weighted MRI in diagnosis of multiple system atrophy. A practical approach for clinicians . J NEUROL, 254(9): 1184-8.
  15. Werner C, Brunner E (2007) Rank methods for the analysis of clustered data in diagnostic trials. COMPUT STAT DATA AN, 51(10): 5041-54.
  16. Wiegand A, Stock A, Attin R, Werner C, Attin T (2007) Impact of the acid flow rate on dentin erosion. J DENT, 35(1): 21-7.
  17. Wiegand A, Wegehaupt F, Werner C, Attin T (2007) Susceptibility of acid-softened enamel to mechanical wear-- ultrasonication versus toothbrushing abrasion. CARIES RES, 41(1): 56-60.



  1. Attin R, Ilse A, Werner C, Wiegand A, Attin T (2006) Antimicrobial effectiveness of a highly concentrated chlorhexidine varnish treatment in teenagers with fixed orthodontic appliances. ANGLE ORTHOD, 76(6): 1022-7.
  2. Betke H, Kahler E, Reitz A, Hartmann G, Lennon A, Attin T (2006) Influence of bleaching agents and desensitizing varnishes on the water content of dentin. OPER DENT, 31(5): 536-42.
  3. Bünger J, Schappler-Scheele B, Hilgers R, Hallier E (2006) A 5-year follow-up study on respiratory disorders and lung function in workers exposed to organic dust from composting plants. INT ARCH OCC ENV HEA, 80(4): 306-12.
  4. Chen TW, Lin BJ, Brunner E, Schild D (2006) In situ background estimation in quantitative fluorescence imaging. BIOPHYS J, 90(7): 2534-47.
  5. Christiansen H, Hermann RM, Martin A, Florez R, Kahler E, Nitsche M, Hille A, Steiner W, Hess CF, Pradier O (2006) Long-term follow-up after transoral laser microsurgery and adjuvant radiotherapy for advanced recurrent squamous cell carcinoma of the head and neck. INT J RADIAT ONCOL, 65(4): 1067-74.
  6. Frosch KH, Drengk A, Krause P, Viereck V, Miosge N, Werner C, Schild D, Stürmer EK, Stürmer KM (2006) Stem cell-coated titanium implants for the partial joint resurfacing of the knee. BIOMATERIALS, 27(12): 2542-9.
  7. Hannig C, Duong S, Becker K, Brunner E, Kahler E, Attin T (2006) Effect of bleaching on subsurface micro-hardness of composite and a polyacid modified composite. DENT MATER, 23(3): 198-203.
  8. Koziolek MJ, Gauczinski S, Kahler E, Bramlage CP, Scheel AK, Mueller GA, Strutz F (2006) Bioimpedance analysis and intradialytic hypotension in intermittent hemodialysis. CLIN NEPHROL, 66(1): 39-50.
  9. Kretschmer L, Hilgers R (2006) Research Supports the View that Sentinel Node Biopsy Is the Standard of Care in High-Risk Primary Melanoma. J CLIN ONCOL, 24(18): 2965-6.
  10. Kunze E, Von Bonin F, Werner C, Wendt M, Schlott T (2006) Transitional cell carcinomas and nonurothelial carcinomas of the urinary bladder differ in the promoter methylation status of the caveolin-1, hDAB2IP and p53 genes, but not in the global methylation of Alu elements. INT J MOL MED, 17(1): 3-13.
  11. Landgrebe J, Bretz F, Brunner E (2006) Efficient design and analysis of two colour factorial microarray experiments. COMPUT STAT DATA AN, 50(2): 499-517.
  12. Mollenhauer B, Bibl M, Wiltfang J, Steinacker P, Ciesielczyk B, Neubert K, Trenkwalder C, Otto M (2006) Total tau protein phosphorylated tau (181p) protein beta-amyloid(1-42), and beta-amyloid(1-40) in cerebrospinal fluid of patients with dementia with Lewy bodies . CLIN CHEM LAB MED, 44(2): 192-5.
  13. Obenauer S, Sohns C, Werner C, Grabbe E (2006) Impact of breast density on computer-aided detection in full-field digital mammography. J DIGIT IMAGING, 19(3): 258-63.
  14. Obenauer S, Sohns C, Werner C, Grabbe E (2006) Computer-aided detection in full-field digital mammography: detection in dependence of the BI-RADS categories. Breast J, 12(1): 16-9.
  15. Olthoff A, Steuer-Vogt MK, Licht K, Sauer-Goenen M, Werner C, Ambrosch P (2006) Quality of life after treatment for laryngeal carcinomas. ORL J OTO-RHINO-LARY, 68(5): 191-196.
  16. Penkalla R, Bedke J, Hemmerlein B, Kahler E, Strauss A, Zöller GM, Heuser M (2006) Changes of microvascular perfusion during acute ureteral obstruction in the rat kidney - the influence of gastrin releasing peptide. CLIN HEMORHEOL MICRO, 34(4): 519-28.
  17. Pohl D, Krone B, Rostasy K, Kahler E, Brunner E, Lehnert M, Wagner HJ, Gärtner J, Hanefeld F (2006) High seroprevalence of Epstein-Barr virus in children with multiple sclerosis . NEUROLOGY, 67(11): 2063-5.
  18. Scheel AK, Hermann KG, Ohrndorf S, Werner C, Schirmer C, Detert J, Bollow M, Hamm B, Müller GA, Burmester GR, Backhaus M (2006) Prospective 7 year follow up imaging study comparing radiography, ultrasonography, and magnetic resonance imaging in rheumatoid arthritis finger joints. ANN RHEUM DIS, 65(5): 595-600.
  19. Schünemann M, Heidrich G, Sahlmann CO, Siefker U, Luig H, Werner C, Brunner E, Meller J (2006) [Improvement of tomographic reconstruction in bone SPECT]. NUKLEARMED-NUCL MED, 45(1): 35-40.
  20. Stoehr GA, Sobh JN, Luecken J, Heidemann K, Mittler U, Hilgers R, Eber SW (2006) Near-total splenectomy for hereditary spherocytosis: clinical prospects in relation to disease severity. BRIT J HAEMATOL, 132(6): 791-3.
  21. Viereck V, Nebel M, Bader W, Harms L, Lange R, Hilgers R, Emons G (2006) Role of bladder neck mobility and urethral closure pressure in predicting outcome of tension-free vaginal tape (TVT) procedure. ULTRASOUND OBST GYN, 28(2): 214-20.
  22. Viereck V, Pauer HU, Hesse O, Bader W, Tunn R, Lange R, Hilgers R, Emons G (2006) Urethral hypermobility after anti-incontinence surgery - a prognostic indicator? INT UROGYNECOL J, 17(6): 586-92.
  23. Wiegand A, Caspar C, Becker K, Werner C, Attin T (2006) [In vitro cytotoxicity of different self-etching dental adhesive systems]. Schweiz Monatsschr Zahnmed, 116(6): 614-21.
  24. Wiegand A, Müller J, Werner C, Attin T (2006) Prevalence of erosive tooth wear and associated risk factors in 2-7-year-old German kindergarten children. ORAL DIS, 12(2): 117-24.
  25. Yakut T, Schulten HJ, Demir A, Frank D, Danner B, Egeli U, Gebitekin C, Kahler E, Gunawan B, Urer N, Oztürk H, Füzesi L (2006) Assessment of molecular events in squamous and non-squamous cell lung carcinoma. LUNG CANCER, 54(3): 293-301.