MetastaSys


Publications


2017

Sahlmann CO, Homayounfar K, Niessner M, Dyczkowski J, Conradi LC, Braulke F, Meller B, Beißbarth T, Ghadimi BM, Meller J, Goldenberg DM, Liersch T. Repeated adjuvant anti-CEA radioimmunotherapy after resection of colorectal liver metastases: Safety, feasibility, and long-term efficacy results of a prospective phase 2 study. Cancer. 2017 Feb 15;123(4):638-649.

Barrantes-Freer A, Engel AS, Rodriguez-Villagra OA, Winkler A, Bergmann M, Mawrin C, Kuempfel T, Pellkofer H, Metz I, Bleckmann A, Hernandez-Duran S, Schippling S, Rushing EJ, Frank S, Glatzel M, Matschke J, Hartmann C, Reifenberger G, Muller W, Schildhaus HU, Bruck W, Stadelmann C. Diagnostic Red Flags: Steroid-Treated Malignant CNS Lymphoma Mimicking Autoimmune Inflammatory Demyelination. Brain Pathol, 2017, Epub ahead of print.

2016

Wachter, A., and Beißbarth, T. Decoding Cellular Dynamics in Epidermal Growth Factor Signaling Using a New Pathway-Based Integration Approach for Proteomics and Transcriptomics Data. Front. Genet, 2016, 351.

Wlochowitz, D., Haubrock, M., Arackal, J., Bleckmann, A., Wolff, A., Beißbarth, T., Wingender, E., and Gültas, M. Computational Identification of Key Regulators in Two Different Colorectal Cancer Cell Lines. Frontiers. in. Genetics, 2016, 7, 42.

Von der Heyde S, Sonntag J, Kramer F, Bender C, Korf U, Beißbarth T (2016). Reconstruction of Protein Networks Using Reverse-Phase Protein Array Data. In Statistical Analysis in Proteomics, K. Jung, ed. (Springer New York), pp. 227–246.

Sprenger T, Rothe H, Conradi LC, Beissbarth T, Kauffels A, Kitz J, Homayounfar K, Wolff H, Ströbel P, Ghadimi M, Wittekind C, Sauer R, Rödel C, Liersch T. Stage-Dependent Frequency of Lymph Node Metastases in Patients With Rectal Carcinoma After Preoperative Chemoradiation: Results from the CAO/ARO/AIO-94 Trial and From a Comparative Prospective Evaluation With Extensive Pathological Workup. Dis Colon Rectum. 2016 May;59(5):377-85.

Bleckmann A, Conradi LC, Menck K, Schmick NA, Schubert A, Rietkötter E, Arackal J, Middel P, Schambony A, Liersch T, Homayounfar K, Beißbarth T, Klemm F, Binder C, Pukrop T. ß-catenin-independent WNT signaling and Ki67 in contrast to the estrogen receptor status are prognostic and associated with poor prognosis in breast cancer liver metastases. Clin Exp Metastasis, 2016, 33, 309–323.

Jo P, Nietert M, Gusky L, Kitz J, Conradi LC, Müller-Dornieden A, Schüler P, Wolff HA, Rüschoff J, Ströbel P, Grade M, Liersch T, Beißbarth T, Ghadimi MB, Sax U, Gaedcke J. Neoadjuvant Therapy in Rectal Cancer - Biobanking of Preoperative Tumor Biopsies. Sci Rep. 2016 Oct 18;6:35589.

2015

Wachter A, Beissbarth T. pwOmics: an R package for pathway-based integration of time-series omics data using public database knowledge. Bioinformatics, 2015, 31(18):3072-4.

Wachter A, Bernhardt S, Beissbarth T, Korf U. Analysis of Reverse Phase Protein Array Data: From Experimental Design towards Targeted Biomarker Discovery. Microarrays (Basel). 2015 Nov 3;4(4):520-39.

Styczen H, Nagelmeier I, Beissbarth T, Nietert M, Homayounfar K, Sprenger T, Boczek U, Stanek K, Kitz J, Wolff HA, Ghadimi BM, Middel P, Liersch T, Rüschoff J, Conradi LC. HER-2 and HER-3 expression in liver metastases of patients with colorectal cancer. Oncotarget. 2015 Jun 20;6(17):15065-76.

Siam L, Bleckmann A, Chaung HN, Mohr A, Klemm F, Barrantes-Freer A, Blazquez R, Wolff HA, Lüke F, Rohde V, Stadelmann C, Pukrop T. The metastatic infiltration at the metastasis/brain parenchyma-interface is very heterogeneous and has a significant impact on survival in a prospective study. Oncotarget, 2015, 6, 29254–29267.

Rietkötter, E., Bleckmann, A., Bayerlová, M., Menck, K., Chuang, H.-N., Wenske, B., Schwartz, H., Erez, N., Binder, C., Hanisch, U.-K., Pukrop, T. Anti-CSF-1 treatment is effective to prevent carcinoma invasion induced by monocyte-derived cells but scarcely by microglia. Oncotarget, 2015, 6, 15482–15493.

Menck K, Scharf C, Bleckmann A, Dyck L, Rost U, Wenzel D, Dhople VM, Siam L, Pukrop T, Binder C, Klemm F: Tumor-derived microvesicles mediate human breast cancer invasion through differentially glycosylated EMMPRIN. J Mol Cell Biol 2015, 143-153.

Bayerlová M, Jung K, Kramer F, Klemm F, Bleckmann A, and Beißbarth T. Comparative study on gene set and pathway topology-based enrichment methods. BMC Bioinformatics, 2015, 16, 334.

Bayerlová, M., Klemm, F., Kramer, F., Pukrop, T., Beißbarth, T., and Bleckmann, A. (2015a). Newly Constructed Network Models of Different WNT Signaling Cascades Applied to Breast Cancer Expression Data. PLOS ONE 10, e0144014.

Bleckmann A, Leha A, Artmann S, Menck K, Salinas-Riester G, Binder C, Pukrop T, Beißbarth T, Klemm F: Integrated miRNA and mRNA profiling of tumor-educated macrophages identifies prognostic subgroups in estrogen receptor-positive breast cancer, Mol. Oncol. 2015, doi:10.1016/j.molonc.2014.07.023.

Von der Heyde S, Wagner S, Czerny A, Nietert M, Ludewig F, Salinas-Riester G, Arlt D, Beißbarth T: mRNA Profiling Reveals Determinants of Trastuzumab Efficiency in HER2-Positive Breast Cancer. PLoS ONE 2015, 10:e0117818.

2014

Von der Heyde S, Sonntag J, Kaschek D, Bender C, Bues J, Wachter A, Timmer J, Korf U, Beißbarth T: RPPanalyzer Toolbox: An improved R package for analysis of reverse phase protein array data. BioTechniques 2014, 57:125–135.

Sonntag J, Bender C, Soons Z, der Heyde S von, König R, Wiemann S, Sinn H-P, Schneeweiss A, Beißbarth T, Korf U: Reverse phase protein array based tumor profiling identifies a biomarker signature for risk classification of hormone receptor-positive breast cancer. Translational Proteomics 2014, 2:52–59.

Menck K, Scharf C, Bleckmann A, Dyck L, Rost U, Wenzel D, Dhople VM, Siam L, Pukrop T, Binder C, Klemm F: Tumor-derived microvesicles mediate human breast cancer invasion through differentially glycosylated EMMPRIN. J Mol Cell Biol 2014:mju047.

Jung K, Dihazi H, Bibi A, Dihazi GH, Beißbarth T: Adaption of the global test idea to proteomics data with missing values. Bioinformatics 2014, 30:1424–1430.

Homayounfar K, Bleckmann A, Helms H-J, Lordick F, Rüschoff J, Conradi L-C, Sprenger T, Ghadimi M, Liersch T: Discrepancies between medical oncologists and surgeons in assessment of resectability and indication for chemotherapy in patients with colorectal liver metastases. Br J Surg 2014, 101:550–557.

Heyde SV der, Bender C, Henjes F, Sonntag J, Korf U, Beißbarth T: Boolean ErbB network reconstructions and perturbation simulations reveal individual drug response in different breast cancer cell lines. BMC Systems Biology 2014, 8:75.

Bleckmann A, Leha A, Artmann S, Menck K, Salinas-Riester G, Binder C, Pukrop T, Beißbarth T, Klemm F: Integrated miRNA and mRNA profiling of tumor-educated macrophages identifies prognostic subgroups in estrogen receptor-positive breast cancer. Molecular Oncology 2014.

Binder C, Chuang E, Habla C, Bleckmann A, Schulz M, Bathgate R, Einspanier A: Relaxins enhance growth of spontaneous murine breast cancers as well as metastatic colonization of the brain. Clin Exp Metastasis 2014, 31:57–65.

Akbani R, Becker K-F, Carragher N, Goldstein T, de Koning L, Korf U, Liotta L, Mills GB, Nishizuka SS, Pawlak M, Petricoin EF, Pollard HB, Serrels B, Zhu J: Realizing the promise of reverse phase protein arrays for clinical, translational, and basic research: a workshop report: the RPPA (Reverse Phase Protein Array) society. Mol Cell Proteomics 2014, 13:1625–1643.

2013

Rietkötter E, Menck K, Bleckmann A, Farhat K, Schaffrinski M, Schulz M, Hanisch U-K, Binder C, Pukrop T: Zoledronic acid inhibits macrophage/microglia-assisted breast cancer cell invasion. Oncotarget 2013, 4:1449–1460.

Pelczar P, Zibat A, van Dop WA, Heijmans J, Bleckmann A, Gruber W, Nitzki F, Uhmann A, Guijarro MV, Hernando E, Dittmann K, Wienands J, Dressel R, Wojnowski L, Binder C, Taguchi T, Beißbarth T, Hogendoorn PCW, Antonescu CR, Rubin BP, Schulz–Schaeffer W, Aberger F, van den Brink GR, Hahn H: Inactivation of Patched1 in Mice Leads to Development of Gastrointestinal Stromal-Like Tumors That Express Pdgfra but Not Kit. Gastroenterology 2013, 144:134–144.e6.

Krause P, Flikweert H, Monin M, Hosseini ASA, Helms G, Cantanhede G, Ghadimi BM, Koenig S: Increased growth of colorectal liver metastasis following partial hepatectomy. Clin Exp Metastasis 2013, 30:681–693.

Kramer F, Bayerlová M, Klemm F, Bleckmann A, Beißbarth T: rBiopaxParser—an R package to parse, modify and visualize BioPAX data. Bioinformatics 2013, 29:520–522.

Homayounfar K, Bleckmann A, Conradi LC, Sprenger T, Lorf T, Niessner M, Sahlmann CO, Meller J, Liersch T, Ghadimi BM: Metastatic recurrence after complete resection of colorectal liver metastases: impact of surgery and chemotherapy on survival. Int J Colorectal Dis 2013, 28:1009–1017.

Fuchs M, Beißbarth T, Wingender E, Jung K: Connecting high-dimensional mRNA and miRNA expression data for binary medical classification problems. Computer Methods and Programs in Biomedicine 2013, 111:592–601.

Chuang H-N, van Rossum D, Sieger D, Siam L, Klemm F, Bleckmann A, Bayerlová M, Farhat K, Scheffel J, Schulz M, Dehghani F, Stadelmann C, Hanisch U-K, Binder C, Pukrop T: Carcinoma cells misuse the host tissue damage response to invade the brain. Glia 2013, 61:1331–1346.

Chuang H-N, Lohaus R, Hanisch U-K, Binder C, Dehghani F, Pukrop T: Coculture System with an Organotypic Brain Slice and 3D Spheroid of Carcinoma Cells. J Vis Exp 2013.

Bleckmann A, Siam L, Klemm F, Rietkötter E, Wegner C, Kramer F, Beißbarth T, Binder C, Stadelmann C, Pukrop T: Nuclear LEF1/TCF4 correlate with poor prognosis but not with nuclear ß-catenin in cerebral metastasis of lung adenocarcinomas. Clin Exp Metastasis 2013, 30:471–482.