Institut für Medizinische Statistik - UMG

Dr. Katharina Kramer

AG Klinische Studien
Humboldtallee 32, Etage 1, 132

Statistik in der Medizin, insbesondere Diagnosestudien.

Nichtparametrische Statistik.
Kurzer Lebenslauf

[11/2008 - dato] Wissenschaftliche Mitarbeiterin in der Abteilung Medizinische Statistik,
der Universitätsmedizin Göttingen.
[04/2009 - 03/2011] Promotion im Promotionskolleg
„Georg-August University School of Science (GAUSS)“
der Georg-August-Universität Göttingen (Doktorvater: Prof. Dr. Brunner)
Dissertation zum Thema Diagnosestudien, Titel:
„Nichtparametrische Analyse diagnostischer Gütemaße bei Clusterdaten“
[10/2003 - 10/2008] Mathematik-Studium an der Georg-August-Universität Göttingen
Diplomarbeit zum Thema Diagnosestudien, Titel:
„Nichtparametrische Modelle für faktorielle Diagnosestudien“
(Betreuer: Prof. Dr. Brunner)
[06/2003] Allgemeine Hochschulreife


facROC: The R-Package performs a nonparametric analysis of diagnostic accuracy measurements in arbitrary factorial designs without cluster data.

The package is uploaded at

• The build Linux (tar.gz) and Windows (zip) versions of this package are available for download in the repository at (Click “View Raw” in order to download the package.)
• To install directly from github you need package devtools.
Package devtools is available at CRAN. For Windows this depends on having Rtools for Windows installed. You can download and install this from: (click YES when asked to add Rtools to Windows PATH variable).

install_github(repo="facROC", username="KatharinaLange")

Publikationen: Arbeiten in referierten Zeitschriften

Methodische Arbeiten / Erstautorschaften


Brockmeyer P, Lange K, Hahn W, Schliephake H, Matthias Gruber R. (2014) Increase of homogenous new bone formation using osteoinductive factor rhGDF-5 during sinus floor augmentation in Goettingen Minipigs. Clinical Oral Implants Research, 00:1–7 (geteilte Erstautorschaft PB und KL). [Abstract]


Lange K, Brunner E (2013) Analysis of Predictive Values Based on Individual Risk Factors in Multi-Modality Trials. Diagnostics, 3(1), 192-209. [Open Access]


Lange K, Brunner E (2012). Sensitivity, specificity and ROC-curves in multiple reader diagnostic trials — A unified, nonparametric approach. Statistical Methodology 9: 490–500. [Abstract]

Konietschke, F. , Harrar, S.W., Lange, K., Brunner, E. (2012). Ranking procedures for matched pairs with missing values - Asymptotic theory and a small sample approximation. Computational Statistics & Data Analysis, 56(5): 1090-1102.


In Druck

Schmidt C, Gerlach N, Peter C, Gherib K, Lange K, Friede T, Zerr I. (2014) Cerebrospinal Fluid Apolipoprotein E Concentration and Progression of Alzheimer's Disease. Journal of Alzheimer’s Disease (in press).

Rinke S, Roediger M, Eickholz P, Lange K, Ziebolz D. (2014) Technical and biological complications of single-molar implant restorations. Clinical Oral Implants Research (in press).

Schmidt C, Wolff M, von Ahsen N, Lange K, Friede T, Zerr I. (2014) CR1 is potentially associated with rate of decline in sporadic Alzheimer's disease. Journal of Clinical Neuroscience (in press).

Schmidt C, Becker H, Peter C, Lange K, Friede T, Zerr I. (2014) Plasma prion protein concentration and progression of Alzheimer's disease. Prion (in press).


Rödiger M, Rinke S, Ehret-Kleinau F, Pohlmeyer F, Lange K, Bürgers R, Gersdorff N. (2014) Evaluation of removal forces of implant-supported zirconia copings depending on abutment geometry, luting agent and cleaning method during re-cementation. Journal of Advanced Prosthodontics, 6(3):233-40. [Abstract]

Schmickler J, Wurbs S, Wurbs S, Lange K, Rinke S, Hornecker E, Mausberg RF, Ziebolz D. (2014) Influence of the utilization time of different manual toothbrushes on oral hygiene assessed during a 6-month observation period: a randomized clinical trial. Journal of Periodontology, 85(8):1050-8. [Abstract]

Gruber RM, Krohn S, Mauth C, Dard M, Molenberg A, Lange K, Perske C, Schliephake H. (2014) Mandibular reconstruction using a calcium phosphate/polyethylene glycol hydrogel carrier with BMP-2. Journal of Clinical Periodontology, 41(8):820-6. [Abstract]


Nagy GCs, Wunsch M, Jordan A, Lange K (2013) Antegrade Eversion Endarterectomy of the External Iliac Artery. European Journal of Vascular and Endovascular Surgery, 46(1):103-9 [Abstract]

Rinke S, Schäfer S, Lange K, Gersdorff N, Roediger M. (2013) Practice-based clinical evaluation of metal-ceramic and zirconia molar crowns: 3 year result. Journal of Oral Rehabilitation, 40(3):228-37 [Abstract].

Rinke S, Lange K, Ziebolz D. (2013) Retrospective Study of Extensive Heat-Pressed Ceramic Veneers after 36 Month. Journal of Esthetic and Restorative Dentistry, 25(1):42-52. [Abstract].

Rinke S, Gersdorff N, Lange K, Roediger M. (2012) Prospective Evaluation of Zirconia Posterior Fixed Partial Dentures: 7-Year Clinical Results. International Journal of Prosthodontics and Restorative Dentistry, 26(2):164-71 [Abstract].


Temme J, Kramer A, Jager KJ, Lange K, Peters F, Müller GA, Kramar R, Heaf JG, Finne P, Palsson R, Reisæter AV, Hoitsma AJ, Metcalfe W, Postorino M, Zurriaga O, Santos JP, Ravani P, Jarraya F, Verrina E, Dekker FW, Gross O. (2012) Outcomes of male patients with Alport syndrome undergoing renal replacement therapy. Clinical Journal of the American Society of Nephrology. 7(12):1969-76. [Abstract].

Rinke S, Fornefett D,Gersdorff N, Lange K, Roediger M. (2012) Multifactorial analysis of the impact of different manufacturing processes on the marginal fit of zirconia copings. Dental Materials Journal, 31(4):601-9

Lange K, Bähr M, Hein K.(2012) Author response: retinal nerve fiber layer thickness measurements in rats with the spectral domain optical coherence tomography. Investigative Ophthalmology & Visual Science, 53(7): 3570-3571

Temme J, Peters F, Lange K, Pirson Y, Heidet L, Torra R, Grunfeld JP, Weber M, Licht C, Müller GA, Gross O. (2012) Incidence of renal failure and nephroprotection by RAAS inhibition in heterozygous carriers of X-chromosomal and autosomal recessive Alport mutations. Kidney international 81: 779-783. [Abstract].

Hein K, Gadjanski I, Kretzschmar B, Lange K, Diem R, Sättler MB, Bähr M. (2012) An optical coherence tomography study on degeneration of retinal nerve fiber layer in rats with autoimmune optic neuritis. Investigative Ophthalmology & Visual Science, 53(1):157-163.

Gross O , Licht C, Anders HJ, Hoppe B, Beck B, Tönshoff B, Höcker B, Wygoda S, Ehrich JHH, Pape L, Konrad M, Rascher W, Dötsch J, Müller-Wiefel DE, Hoyer P, and Study Group Members of the Gesellschaft für Pädiatrische Nephrologie (GPN), Knebelmann B, Pirson Y, Grunfeld JP, Niaudet P, Cochat P, Heidet L, Torra R, Friede T, Lange K, Müller GA, Weber M. (2012). Early angiotensin-converting enzyme inhibition in Alport syndrome delays renal failure and improves life expectancy. Kidney International 81(5): 494-501. [Abstract].


Hahn W, Wasser-Merkel W, Lange K, Gruber RM, Kubein-Meesenburg D ; Ihlow, D. (2011). Accuracy of fit of 3-to-3 retainers after adhesive fixation using a neodymium–iron–boron magnet chain. Journal of Orofacial Orthopedics / Fortschritte der Kieferorthopdie, 72(5): 381-388.

Ziebolz D, Pabel SO, Lange K, Krohn-Grimberghe B, Hornecker E, Mausberg RF. (2011) Clinical Periodontal and Microbiologic Parameters in Patients with Rheumatoid Arthritis. J Periodontology, 82(10):1424-1432.

Rossenbach J, Mueller GA, Lange K, Armstrong VW, Schmitto JD, Hintze E, Helfmann J, Konstantinides S, Koziolek MJ. (2011) Lipid-apheresis improves microcirculation of the upper limbs. Journal of Clinical Apheresis, 26: 167–173.

Bramlage CP, Müller GA, Tampe B, Bevanda J, Maatouk I, Koziolek M, Lange K, Ahrens K, Schmid H, Cohen CD, Bramlage P, Kretzler M, Strutz F. (2011) The role of bone morphogenetic protein-5 (BMP-5) in human nephrosclerosis. Journal of Nephrology, 24(5): 647-655.

Rinke S, Ohl S, Ziebolz D, Lange K, Eickholz P. (2011) Prevalence of periimplant disease in partially edentulous patients: a practice-based cross-sectional study. Clinical Oral Implants Research, 22: 826–833.


Bramlage CP, Tampe B, Koziolek M, Maatouk I, Bevanda J, Bramlage P, Ahrens K, Lange K, Schmid H, Cohen CD, Kretzler M, Müller GA. (2010) Bone Morphogenetic Protein (BMP)-7 expression is decreased in human hypertensive nephrosclerosis. BMC Nephrol. 2010 Nov 16;11:31. PubMed PMID: 21080950; PubMed Central PMCID: PMC3002344.

Rödig T, Sedghi M, Konietschke F, Lange K, Ziebolz D, Hülsmann M. (2010) Efficacy of syringe irrigation, RinsEndo and passive ultrasonic irrigation in removing debris from irregularities in root canals with different apical sizes. Int Endod J. 2010 Jul;43(7):581-9. PubMed PMID: 20636517.


DagStat 2013 (Freiburg): "Analyzing Factorial Diagnostic Trials: The R-Package facROC"

Herbstworkshop „Methodische Probleme in Diagnostischen Studien“ (Göttingen):
„Analyse diagnostischer Gütemaße in faktoriellen Versuchsanlagen: das R-Paket facROC“

CEN 2011 (Zürich): „Nonparametric analysis of diagnostic trials regarding clustered data“

Kolloquium: Statistische Methoden in der empirischen Forschung (Berlin): „Trennung von Einflussfaktoren in Diagnosestudien“ (Vertretung für Prof. Dr. Brunner)

Nachwuchsworkshop der DStatG 2010 (Nürnberg): „Statistische Methoden in Diagnostik: Ein einheitlicher Analyseansatz für verschiedene diagnostische Gütemaße“

GMDS 2010 (Mannheim): „Prädiktive Werte als Gütemaße in Diagnosestudien: Anwendungsmöglichkeiten und Analysemethoden“

Eingeladene Rednerin beim Workshop zu Ehren Prof. Dr. Brunners (Göttingen): „Predictive Values in Diagnostic Trials: Points to Consider and Methods of Analysis“

DAGStat 2010 (Dortmund) „Sensitivität, Spezifität und die Fläche unter der ROC-Kurve als Effektmaße in Diagnosestudien - ein einheitlicher, nichtparametrischer Analyseansatz“

GMDS 2009 (Essen) „Nichtparametrische Modelle für faktorielle Diagnosestudien