Department of Medical Statistics, University Goettingen

Dr. Andreas Leha

Head of the Core Facility
Medical Biometry and Statistical Bioinformatics
Office room:
Humboldtallee 32, GF, 162

Research Interests


Winter Term 2018/2019

Winter Term 2017/2018

Short Vita:


Selected Publications

  1. Biomarkers predict outcome in Charcot Marie Tooth Disease 1A
    Robert Fledrich, Manoj Mannil, Andreas Leha, Caroline Ehbrecht, Alessandra Solari, Ana L. Pelayo-Negro, José Berciano, Beate Schlotter-Weigel, Tuuli J. Schnizer, Thomas Prukop, Natalia Garcia-Angarita, Dirk Czesnik, Jana Haberlová1, Radim Mazanec1, Walter Paulus, Tim Beissbarth, Maggie C. Walter, CMT-TRIAAL, Jean-Yves Hogrel, Odile Dubourg, Angelo Schenone, Jonathan Baets, Peter De Jonghe, Michael E. Shy, Rita Horvath, Davide Pareyson, Pavel Seeman, Peter Young, and Michael W. Sereda
    Journal of Neurology, Neurosurgery & Psychiatry, 2017, in Press, Shared First
  2. Common genetic variation drives molecular heterogeneity in human iPSCs
    Helena Kilpinen, Angela Goncalves, Andreas Leha, Vackar Afzal, Kaur Alasoo, Sofie Ashford, Sendu Bala, Dalila Bensaddek, Francesco Paolo Casale, Oliver J. Culley, Petr Danecek, Adam Faulconbridge, Peter W. Harrison, Annie Kathuria, Davis McCarthy, Shane A. McCarthy, Ruta Meleckyte, Yasin Memari, Nathalie Moens, Filipa Soares, Alice Mann, Ian Streeter, Chukwuma A. Agu, Alex Alderton, Rachel Nelson, Sarah Harper, Minal Patel, Alistair White, Sharad R. Patel, Laura Clarke, Reena Halai, Christopher M. Kirton, Anja Kolb-Kokocinski, Philip Beales, Ewan Birney, Davide Danovi, Angus I. Lamond, Willem H. Ouwehand, Ludovic Vallier, Fiona M. Watt, Richard Durbin, Oliver Stegle, and Daniel J. Gaffney
    Nature, 2017, 546, 370-375
  3. A high-content platform to characterise human induced pluripotent stem cell lines
    Andreas Leha, Nathalie Moens, Ruta Meleckyte, Oliver J. Culley, Mia K. Gervasio, Maximilian Kerz, Andreas Reimer, Stuart A. Cain, Ian Streeter, Amos Folarin, Oliver Stegle, Cay M. Kielty, HipSci Consortium, Richard Durbin, Fiona M. Watt, and Davide Danovi
    Methods, 2016 Mar 1;96:85-96
  4. Comprehensive identification of genes driven by ERV9-LTRs reveals TNFRSF10B as a re-activatable mediator of testicular cancer cell death Ulrike Beyer, Sonja K. Krönung, Andreas Leha, Lutz Walter, and Matthias Dobbelstein
    Cell Death and Differentiation, 2016, 23, 64-75
  5. Interactions of human MSC with head and neck squamous cell carcinoma cell line PCI-13 reduce markers of epithelia-mesenchymal transition
    Florian Böhrnsen, Martin Fricke, Charlotte Sander, Andreas Leha, Henning Schliephake, and Franz-Joseph Kramer
    Clinical Oral Investigations, 2014, pp. 1-8
  6. Integrated miRNA and mRNA profiling of tumor-educated macrophages identifies prognostic subgroups in estrogen receptor-positive breast cancer.
    Bleckmann A, Leha A, Artmann S, Menck K, Salinas-Riester G, Binder C, Pukrop T, Beißbarth T*, Klemm F*.
    Mol Oncol, 2015, 9(1):155-66.
  7. Identification of a DNA methylation signature to predict disease-free survival in locally advanced rectal cancer.
    Gaedcke J, Leha A, Claus R, Weichenhan D, Jung K, Kitz J, Grade M, Wolff HA, Jo P, Doyen J, Gérard JP, Johnsen SA, Plass C, Beißbarth T, Ghadimi M.
    Oncotarget, 2014, 5(18):8123-35.
  8. Selected items from the Charcot-Marie-Tooth (CMT) Neuropathy Score and secondary clinical outcome measures serve as sensitive clinical markers of disease severity in CMT1A patients.
    Mannil M, Solari A, Leha A, Pelayo-Negro AL, Berciano J, Schlotter-Weigel B, Walter MC, Rautenstrauss B, Schnizer TJ, Schenone A, Seeman P, Kadian C, Schreiber O, Angarita NG, Fabrizi GM, Gemignani F, Padua L, Santoro L, Quattrone A, Vita G, Calabrese D; CMT-TRIAAL/CMT-TRAUK Group, Young P, Laurà M, Haberlová J, Mazanec R, Paulus W, Beißbarth T, Shy ME, Reilly MM, Pareyson D, Sereda MW.
    Neuromuscul Disord, 2014, 24(11):1003-17.
  9. Gender affects acute organ toxicity during radiochemotherapy for rectal cancer: long-term results of the German CAO/ARO/AIO-94 phase III trial.
    Wolff HA, Conradi LC, Beißbarth T, Leha A, Hohenberger W, Merkel S, Fietkau R, Raab HR, Tschmelitsch J, Hess CF, Becker H, Wittekind C, Sauer R, Rödel C, Liersch T; German Rectal Cancer Study Group.
    Radiother Oncol, 2013, 108(1):48-54.
  10. Improvement of Renal Graft Function After Conversion From a Calcineurin Inhibitor Including Immunosuppression to a Mycophenolate Sodium Including Regimen: A 4-year Follow-up
    Michael H J Heeg, Gerhard A Mueller, Carsten Bramlage, Kia Homayounfar, Johannes Muehlhausen, Andreas Leha, and Michael J Koziolek
    Transplantation Proceedings, 2013, 45.1, pp. 142-147
  11. Sequential Interim Analyses of Survival Data in DNA Microarray Experiments.
    Leha A, Beißbarth T, Jung K.
    BMC Bioinformatics, 2011, 12(1):127.
  12. Optimization of simulated production process performance using machine learning
    Andreas Leha, Dejan Pangercic, Thomas Rühr, and Michael Beetz
    IEEE Conference on Emerging Technologies Factory Automation, 2009. ETFA 2009, pp. 1-5
  13. Parallelizing Scientific Code with Invasive Interactive Parallelization: A Case Study with Reuseware
    Andreas Leha, Mikhail Chalabine, and Christoph Kessler
    Proceedings of the 2008 compFrame/HPC-GECO Workshop on Component Based High Performance. CBHPC 08, 2008, 5:1-5:10.